Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 130 results
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2013
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.. Mol Psychiatry. 18(8):882-8.
Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu H-J, Izumi Y et al..  2013.  The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.. J Neurosci. 33(44):17290-300.
Liu CFeng, Liu D, Momb J, Thomas PW, Lajoie A, Petsko GA, Fast W, Ringe D.  2013.  A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.. Biochemistry. 52(9):1603-10.
Auclair JR, Johnson JL, Liu Q, Salisbury JP, Rotunno MS, Petsko GA, Ringe D, Brown RH, Bosco DA, Agar JN.  2013.  Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage.. Biochemistry. 52(36):6137-44.
Auclair JR, Johnson JL, Liu Q, Salisbury JP, Rotunno MS, Petsko GA, Ringe D, Brown RH, Bosco DA, Agar JN.  2013.  Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage.. Biochemistry. 52(36):6137-44.
Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JMM, Pybus B, Ringe D, Petsko GA, Boxer SG et al..  2013.  Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.. Proc Natl Acad Sci U S A. 110(28):E2552-61.
Auclair JR, Brodkin HR, J D'Aquino A, Petsko GA, Ringe D, Agar JN.  2013.  Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase.. Biochemistry. 52(36):6145-50.
2012
Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C.  2012.  The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).. Bioorg Med Chem Lett. 22(12):3900-4.
Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, DeLong C, Lin S, Zhao L et al..  2012.  Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.. Brain Res. 1467:120-32.
Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, M Lachenmayer L, Yue Z, Ehrlich ME, Petsko G, Ju S et al..  2012.  Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.. J Alzheimers Dis. 32(4):949-67.
Auclair JR, Somasundaran M, Green KM, Evans JE, Schiffer CA, Ringe D, Petsko GA, Agar JN.  2012.  Mass spectrometry tools for analysis of intermolecular interactions.. Methods Mol Biol. 896:387-98.
Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD.  2012.  Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury.. Mol Cell Biochem. 365(1-2):351-61.
Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD.  2012.  Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury.. Mol Cell Biochem. 365(1-2):351-61.
Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS.  2012.  Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.. J Neuroinflammation. 9:67.
2011
Cho S-H, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L.  2011.  CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.. J Biol Chem. 286(37):32713-22.
Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, H Koerber R et al..  2011.  The functional organization of cutaneous low-threshold mechanosensory neurons.. Cell. 147(7):1615-27.
Bosco DA, LaVoie MJ, Petsko GA, Ringe D.  2011.  Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.. Cold Spring Harb Perspect Biol. 3(10):a007500.
Witten IB, Steinberg EE, Lee SYeun, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C et al..  2011.  Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.. Neuron. 72(5):721-33.
Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S et al..  2011.  A yeast model of FUS/TLS-dependent cytotoxicity.. PLoS Biol. 9(4):e1001052.
2010
He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP et al..  2010.  Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.. Nature. 467(7311):95-8.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.