Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 394 results
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2024
Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al..  2024.  KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. J Clin Invest. 134(3)
Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al..  2024.  KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. J Clin Invest. 134(3)
Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al..  2024.  KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. J Clin Invest. 134(3)
Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al..  2024.  KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. J Clin Invest. 134(3)
Zheng X, Wu B, Liu Y, Simmons SK, Kim K, Clarke GS, Ashiq A, Park J, Li J, Wang Z et al..  2024.  Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development.. Cell. 187(13):3236-3248.e21.
Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR et al..  2024.  Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.. PNAS Nexus. 3(5):pgae179.
Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR et al..  2024.  Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.. PNAS Nexus. 3(5):pgae179.
Fridy PC, Farrell RJ, Molloy KR, Keegan S, Wang J, Jacobs EY, Li Y, Trivedi J, Sehgal V, Fenyö D et al..  2024.  A new generation of nanobody research tools using improved mass spectrometry-based discovery methods.. J Biol Chem. 300(9):107623.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.
Wallace CH, Oliveros G, Xie L, Serrano P, Rockwell P, Figueiredo-Pereira M.  2024.  Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology.. Sci Rep. 14(1):3730.
Bustos VHugo, Sunkari YKrishna, Sinha A, Pulina M, Bispo A, Hopkins M, Lam A, Kriegsman SF, Mui E, Chang E et al..  2024.  Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels.. ACS Chem Biol. 19(1):37-47.
Bustos VHugo, Sunkari YKrishna, Sinha A, Pulina M, Bispo A, Hopkins M, Lam A, Kriegsman SF, Mui E, Chang E et al..  2024.  Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels.. ACS Chem Biol. 19(1):37-47.
Bustos VHugo, Sunkari YKrishna, Sinha A, Pulina M, Bispo A, Hopkins M, Lam A, Kriegsman SF, Mui E, Chang E et al..  2024.  Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels.. ACS Chem Biol. 19(1):37-47.
Burré J, Edwards RH, Halliday G, Lang AE, Lashuel HA, Melki R, Murayama S, Outeiro TF, Papa SM, Stefanis L et al..  2024.  Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis.. Mov Disord. 39(10):1663-1678.
Burré J, Edwards RH, Halliday G, Lang AE, Lashuel HA, Melki R, Murayama S, Outeiro TF, Papa SM, Stefanis L et al..  2024.  Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis.. Mov Disord. 39(10):1663-1678.
Netzer WJ, Sinha A, Ghias M, Chang E, Gindinova K, Mui E, Seo J-S, Sinha SC.  2024.  Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP.. Front Chem. 12:1381205.
Netzer WJ, Sinha A, Ghias M, Chang E, Gindinova K, Mui E, Seo J-S, Sinha SC.  2024.  Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP.. Front Chem. 12:1381205.
Netzer WJ, Sinha A, Ghias M, Chang E, Gindinova K, Mui E, Seo J-S, Sinha SC.  2024.  Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP.. Front Chem. 12:1381205.
Lopez-Lee C, Kodama L, Fan L, Zhu D, Zhu J, Wong MYing, Ye P, Norman K, Foxe NR, Ijaz L et al..  2024.  Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.. Science. 386(6725):eadk7844.
Wang C, Zhang K, Cai B, Haller JE, Carnazza KE, Hu J, Zhao C, Tian Z, Hu X, Hall D et al..  2024.  VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates.. Nat Cell Biol. 26(8):1287-1295.
2023
Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu G-Q, Yu X, Smith N et al..  2023.  Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.. Neurobiol Dis. 186:106263.