Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 198 results

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2016

Wes PD, Sayed FA, Bard F, Gan L. 2016. Targeting microglia for the treatment of Alzheimer's Disease.. Glia. 64(10):1710-32.

Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. 2016. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 90(4):724-39.

Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. 2016. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 92(1):252-264.

2015

Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu G-Q, Adame A et al.. 2015. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.. Nat Neurosci. 18(3):423-34.

Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu G-Q, Adame A et al.. 2015. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.. Nat Neurosci. 18(3):423-34.

Min S-W, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, S Minami S, Defensor E, Mok SAnn et al.. 2015. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.. Nat Med. 21(10):1154-62.

Cho S-H, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PDongmin, Lo I, Minami S et al.. 2015. SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.. J Neurosci. 35(2):807-18.

Bacaj T, Wu D, Burré J, Malenka RC, Liu X, Südhof TC. 2015. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.. PLoS Biol. 13(10):e1002267.

2014

McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong W-X, Yue Z. 2014. Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.. PLoS Genet. 10(10):e1004626.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LHerl, Seeley WW et al.. 2014. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.

S Minami S, Min S-W, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME et al.. 2014. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.. Nat Med. 20(10):1157-64.

S Minami S, Min S-W, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME et al.. 2014. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.. Nat Med. 20(10):1157-64.

Parmar MS, Jaumotte JD, Wyrostek SL, Zigmond MJ, Cavanaugh JE. 2014. The role of ERK1, 2, and 5 in dopamine neuron survival during aging.. Neurobiol Aging. 35(3):669-79.

Xiao L, Zhang C, Li X, Gong S, Hu R, Balasubramanian R, W WFCrowley, Hastings MH, Zhou Q-Y. 2014. Signaling role of prokineticin 2 on the estrous cycle of female mice.. PLoS One. 9(3):e90860.

2013

Grinberg LTenenholz, Wang X, Wang C, Sohn PDongmin, Theofilas P, Sidhu M, Arevalo JBenjamin, Heinsen H, Huang EJ, Rosen H et al.. 2013. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.. Acta Neuropathol. 125(4):581-93.

Grinberg LTenenholz, Wang X, Wang C, Sohn PDongmin, Theofilas P, Sidhu M, Arevalo JBenjamin, Heinsen H, Huang EJ, Rosen H et al.. 2013. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.. Acta Neuropathol. 125(4):581-93.

Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC et al.. 2013. Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.. Proc Natl Acad Sci U S A. 110(44):17820-5.

Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC et al.. 2013. Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.. Proc Natl Acad Sci U S A. 110(44):17820-5.

Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC et al.. 2013. Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.. Proc Natl Acad Sci U S A. 110(44):17820-5.

Wu X, Gong S, Roy-Burman P, Lee P, Culig Z. 2013. Current mouse and cell models in prostate cancer research.. Endocr Relat Cancer. 20(4):R155-70.

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al.. 2013. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al.. 2013. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.

Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al.. 2013. Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.. Mol Psychiatry. 18(8):882-8.

Shim J-H, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA et al.. 2013. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.. J Clin Invest. 123(9):4010-22.

2012

Wang C, Sun B, Zhou Y, Grubb A, Gan L. 2012. Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.. J Biol Chem. 287(47):39834-41.