Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 46 results
Author Title Type [ Year(Asc)]
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2021
Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MYing, Horowitz R et al..  2021.  AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.. Sci Transl Med. 13(622):eabe3947.
Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang L-L, Huang T, Luo W et al..  2021.  GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.. J Exp Med. 218(8)
Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang L-L, Huang T, Luo W et al..  2021.  GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.. J Exp Med. 218(8)
2020
Telpoukhovskaia MA, Liu K, Sayed FA, Etchegaray JIker, Xie M, Zhan L, Li Y, Zhou Y, Le D, Bahr BA et al..  2020.  Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.. Sci Rep. 10(1):13688.
Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al..  2020.  The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.
2019
Ayed M, Lim H, Xie L.  2019.  Biological representation of chemicals using latent target interaction profile.. BMC Bioinformatics. 20(Suppl 24):674.
Poleksic A, Xie L.  2019.  Database of adverse events associated with drugs and drug combinations.. Sci Rep. 9(1):20025.
Sohn PDongmin, Huang CTzu-Ling, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok S-A, Freilich R et al..  2019.  Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.. Neuron.
Xie L, Xie L.  2019.  Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing.. Int J Mol Sci. 20(14)
Xie L, Xie L.  2019.  Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing.. Int J Mol Sci. 20(14)
Liu Q, He D, Xie L.  2019.  Prediction of off-target specificity and cell-specific fitness of CRISPR-Cas System using attention boosted deep learning and network-based gene feature.. PLoS Comput Biol. 15(10):e1007480.
Lim H, He D, Qiu Y, Krawczuk P, Sun X, Xie L.  2019.  Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology.. PLoS Comput Biol. 15(6):e1006619.
2018
Inoue K, Deng Z, Chen Y, Giannopoulou E, Xu R, Gong S, Greenblatt MB, Mangala LS, Lopez-Berestein G, Kirsch DG et al..  2018.  Bone protection by inhibition of microRNA-182.. Nat Commun. 9(1):4108.
2017
Shi Y, Yamada K, Liddelow SAntony, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC et al..  2017.  ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.. Nature. 549(7673):523-527.
Cao J, Gaamouch FEl, Meabon JS, Meeker KD, Zhu L, Zhong MB, Bendik J, Elder G, Jing P, Xia J et al..  2017.  ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.. Sci Rep. 7(1):11372.
Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PDongmin, Ludwig C, Meyer-Franke A et al..  2017.  Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.. Stem Cell Reports. 9(4):1221-1233.
2014
Xiao L, Zhang C, Li X, Gong S, Hu R, Balasubramanian R, W WFCrowley, Hastings MH, Zhou Q-Y.  2014.  Signaling role of prokineticin 2 on the estrous cycle of female mice.. PLoS One. 9(3):e90860.
2012
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC.  2012.  CSPα knockout causes neurodegeneration by impairing SNAP-25 function.. EMBO J. 31(4):829-41.
2008
Orr AL, Li S, Wang C-E, Li H, Wang J, Rong J, Xu X, Mastroberardino PGiorgio, J Greenamyre T, Li X-J.  2008.  N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.. J Neurosci. 28(11):2783-92.
2003
Luo W-jie, Wang H, Li H, Kim BS, Shah S, Lee H-J, Thinakaran G, Kim T-W, Yu G, Xu H.  2003.  PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.. J Biol Chem. 278(10):7850-4.
1999
Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L.  1999.  Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.. Proc Natl Acad Sci U S A. 96(13):7547-52.