Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 191 results

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2023

Uekawa K, Hattori Y, Ahn SJi, Seo J, Casey N, Anfray A, Zhou P, Luo W, Anrather J, Park L et al.. 2023. Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.. Mol Neurodegener. 18(1):73.

Chen H, Fan L, Guo Q, Wong MYing, Yu F, Foxe N, Wang W, Nessim A, Carling G, Liu B et al.. 2023. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.. Res Sq.

Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HKrishna, Dorogan M, Harding WW et al.. 2023. End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins.. PLoS Comput Biol. 19(1):e1010851.

Luo P, Yang F, Li J, Niemeyer JE, Zhan F, Estin J, Zhao M, Li D, Lin W, Liou J-Y et al.. 2023. Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.. Epilepsia. 64(7):1939-1950.

Luo P, Yang F, Li J, Niemeyer JE, Zhan F, Estin J, Zhao M, Li D, Lin W, Liou J-Y et al.. 2023. Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.. Epilepsia. 64(7):1939-1950.

Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al.. 2023. Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.

Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al.. 2023. Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.

Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al.. 2023. Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.

Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al.. 2023. Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.

Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MYing et al.. 2023. Functional characterization of Alzheimer's disease genetic variants in microglia.. Nat Genet. 55(10):1735-1744.

Bravo CParra, Giani AMaria, Perez JMadero, Zhao Z, Samelson A, Wong MYing, Evangelisti A, Fan L, Pozner T, Mercedes M et al.. 2023. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. bioRxiv.

Bravo CParra, Giani AMaria, Perez JMadero, Zhao Z, Samelson A, Wong MYing, Evangelisti A, Fan L, Pozner T, Mercedes M et al.. 2023. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. bioRxiv.

Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA et al.. 2023. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.. Proc Natl Acad Sci U S A. 120(44):e2310174120.

Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA et al.. 2023. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.. Proc Natl Acad Sci U S A. 120(44):e2310174120.

Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA et al.. 2023. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.. Proc Natl Acad Sci U S A. 120(44):e2310174120.

Liao Z, Xie L, Mamitsuka H, Zhu S. 2023. Sc2Mol: a scaffold-based two-step molecule generator with variational autoencoder and transformer.. Bioinformatics. 39(1)

Lopez-Lee C, Kodama L, Fan L, Wong MYing, Foxe NR, Jiaz L, Yu F, Ye P, Zhu J, Norman K et al.. 2023. Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.. bioRxiv.

Udeochu JC, Amin S, Huang Y, Fan L, Torres ERuth S, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G et al.. 2023. Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.. Nat Neurosci. 26(5):737-750.

Zhang S, Liu Y, Xie L. 2023. A universal framework for accurate and efficient geometric deep learning of molecular systems.. Sci Rep. 13(1):19171.

2022

Pham T-H, Qiu Y, Liu J, Zimmer S, O'Neill E, Xie L, Zhang P. 2022. Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing.. Patterns (N Y). 3(4):100441.

Pham T-H, Qiu Y, Liu J, Zimmer S, O'Neill E, Xie L, Zhang P. 2022. Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing.. Patterns (N Y). 3(4):100441.

Dräger NM, Sattler SM, Huang CTzu-Ling, Teter OM, Leng K, Hashemi SHadi, Hong J, Aviles G, Clelland CD, Zhan L et al.. 2022. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.. Nat Neurosci.

Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al.. 2022. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.

Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al.. 2022. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.

Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al.. 2022. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.