Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 36 results
Author Title Type [ Year(Desc)]
Filters: First Letter Of Title is P  [Clear All Filters]
1991
Lai CF, Gong SC, Esteban M.  1991.  The purified 14-kilodalton envelope protein of vaccinia virus produced in Escherichia coli induces virus immunity in animals.. J Virol. 65(10):5631-5.
2001
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM.  2001.  Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 98(15):8850-5.
2003
Luo W-jie, Wang H, Li H, Kim BS, Shah S, Lee H-J, Thinakaran G, Kim T-W, Yu G, Xu H.  2003.  PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.. J Biol Chem. 278(10):7850-4.
2004
Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR.  2004.  The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. Proc Natl Acad Sci U S A. 101(24):9103-8.
2005
Gu X, Li C, Wei W, Lo V, Gong S, Li S-H, Iwasato T, Itohara S, Li X-J, Mody I et al..  2005.  Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.. Neuron. 46(3):433-44.
2007
Tomishima MJ, Hadjantonakis A-K, Gong S, Studer L.  2007.  Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library.. Stem Cells. 25(1):39-45.
2008
Gan L, Mucke L.  2008.  Paths of convergence: sirtuins in aging and neurodegeneration.. Neuron. 58(1):10-4.
Sanchez-Mejia RO, Newman JW, Toh S, Yu G-Q, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L et al..  2008.  Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.. Nat Neurosci. 11(11):1311-8.
Mannaioni G, Orr AG, Hamill CE, Yuan H, Pedone KH, McCoy KL, Palmini RBerlinguer, Junge CE, C Lee J, Yepes M et al..  2008.  Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.. J Biol Chem. 283(29):20600-11.
2010
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RLA, Kim J, May J, Tocilescu MAleksandra, Liu W, Ko HSeok et al..  2010.  PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.. Proc Natl Acad Sci U S A. 107(1):378-83.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.
2011
Liu W, Acín-Peréz R, Geghman KD, Manfredi G, Lu B, Li C.  2011.  Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.. Proc Natl Acad Sci U S A. 108(31):12920-4.
Kauppinen TM, Suh SWon, Higashi Y, Berman AE, Escartin C, Won SJoon, Wang C, Cho S-H, Gan L, Swanson RA.  2011.  Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.. J Neuroinflammation. 8:152.
Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J.  2011.  Protective effects and mechanisms of sirtuins in the nervous system.. Prog Neurobiol. 95(3):373-95.
Bosco DA, LaVoie MJ, Petsko GA, Ringe D.  2011.  Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.. Cold Spring Harb Perspect Biol. 3(10):a007500.
2012
Martens LHerl, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min S-W, Gan L, Finkbeiner S, Huang EJ et al..  2012.  Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.. J Clin Invest. 122(11):3955-9.
Sharma M, Burré J, Südhof TC.  2012.  Proteasome inhibition alleviates SNARE-dependent neurodegeneration.. Sci Transl Med. 4(147):147ra113.
2013
Liu CFeng, Liu D, Momb J, Thomas PW, Lajoie A, Petsko GA, Fast W, Ringe D.  2013.  A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.. Biochemistry. 52(9):1603-10.
Kauppinen TM, Gan L, Swanson RA.  2013.  Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.. Biochim Biophys Acta. 1833(8):1985-91.
Auclair JR, Johnson JL, Liu Q, Salisbury JP, Rotunno MS, Petsko GA, Ringe D, Brown RH, Bosco DA, Agar JN.  2013.  Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage.. Biochemistry. 52(36):6137-44.
Burré J, Vivona S, Diao J, Sharma M, Brunger AT, Südhof TC.  2013.  Properties of native brain α-synuclein.. Nature. 498(7453):E4-6;discussionE6-7.
2014
Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA.  2014.  Pharmacological chaperones stabilize retromer to limit APP processing.. Nat Chem Biol. 10(6):443-9.
Strauss KA, Markx S, Georgi B, Paul SM, Jinks RN, Hoshi T, McDonald A, First MB, Liu W, Benkert AR et al..  2014.  A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.. Hum Mol Genet. 23(23):6395-406.
Hey-Mogensen M, Goncalves RLS, Orr AL, Brand MD.  2014.  Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.. Free Radic Biol Med. 72:149-55.
S Minami S, Min S-W, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME et al..  2014.  Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.. Nat Med. 20(10):1157-64.