Paths of convergence: sirtuins in aging and neurodegeneration.

TitlePaths of convergence: sirtuins in aging and neurodegeneration.
Publication TypeJournal Article
Year of Publication2008
AuthorsGan L, Mucke L
Date Published2008 Apr 10
KeywordsAnimals, Cell Survival, Cellular Senescence, Humans, Longevity, Nerve Degeneration, Neural Pathways, Sirtuins

Members of the sirtuin family of protein deacetylases support and promote longevity in diverse organisms and can extend life span when upregulated. Sirtuin pathways also modulate fundamental mechanisms in aging-related neurodegenerative diseases, including protein aggregation, stress responses, mitochondrial homeostasis, and inflammatory processes. In this minireview, we will discuss how progress in understanding the neurobiology of sirtuins is shedding light on the pathogenesis of these devastating conditions. We will also examine the potential and challenges of targeting sirtuin pathways therapeutically.

Alternate JournalNeuron
PubMed ID18400158
Grant ListAG011385 / AG / NIA NIH HHS / United States
AG024447 / AG / NIA NIH HHS / United States
NS041787 / NS / NINDS NIH HHS / United States