Title | Paths of convergence: sirtuins in aging and neurodegeneration. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Gan L, Mucke L |
Journal | Neuron |
Volume | 58 |
Issue | 1 |
Pagination | 10-4 |
Date Published | 2008 Apr 10 |
ISSN | 1097-4199 |
Keywords | Animals, Cell Survival, Cellular Senescence, Humans, Longevity, Nerve Degeneration, Neural Pathways, Sirtuins |
Abstract | Members of the sirtuin family of protein deacetylases support and promote longevity in diverse organisms and can extend life span when upregulated. Sirtuin pathways also modulate fundamental mechanisms in aging-related neurodegenerative diseases, including protein aggregation, stress responses, mitochondrial homeostasis, and inflammatory processes. In this minireview, we will discuss how progress in understanding the neurobiology of sirtuins is shedding light on the pathogenesis of these devastating conditions. We will also examine the potential and challenges of targeting sirtuin pathways therapeutically. |
DOI | 10.1016/j.neuron.2008.03.015 |
Alternate Journal | Neuron |
PubMed ID | 18400158 |
Grant List | AG011385 / AG / NIA NIH HHS / United States AG024447 / AG / NIA NIH HHS / United States NS041787 / NS / NINDS NIH HHS / United States |