How to improve R&D productivity: the pharmaceutical industry's grand challenge.

TitleHow to improve R&D productivity: the pharmaceutical industry's grand challenge.
Publication TypeJournal Article
Year of Publication2010
AuthorsPaul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL
JournalNat Rev Drug Discov
Date Published2010 Mar
KeywordsClinical Trials as Topic, Drug Discovery, Drug Industry, Efficiency, Humans, Models, Economic, Research, Research Design, Time Factors

The pharmaceutical industry is under growing pressure from a range of environmental issues, including major losses of revenue owing to patent expirations, increasingly cost-constrained healthcare systems and more demanding regulatory requirements. In our view, the key to tackling the challenges such issues pose to both the future viability of the pharmaceutical industry and advances in healthcare is to substantially increase the number and quality of innovative, cost-effective new medicines, without incurring unsustainable R&D costs. However, it is widely acknowledged that trends in industry R&D productivity have been moving in the opposite direction for a number of years. Here, we present a detailed analysis based on comprehensive, recent, industry-wide data to identify the relative contributions of each of the steps in the drug discovery and development process to overall R&D productivity. We then propose specific strategies that could have the most substantial impact in improving R&D productivity.

Alternate JournalNat Rev Drug Discov
PubMed ID20168317