Identifying Links between Alzheimer's Disease and Type 2 Diabetes through Proteomics.

TitleIdentifying Links between Alzheimer's Disease and Type 2 Diabetes through Proteomics.
Publication TypeJournal Article
Year of Publication2025
AuthorsChen TN, Orr AL, Orr AG, Vacanti NM
JournalJ Proteome Res
Volume24
Issue8
Pagination3733-3740
Date Published2025 Aug 01
ISSN1535-3907
KeywordsAlzheimer Disease, Biomarkers, Diabetes Mellitus, Type 2, Humans, Proteome, Proteomics
Abstract

Alzheimer's disease (AD) and type 2 diabetes (T2D) are both amyloidogenic, age-associated chronic diseases and their occurrences are linked by epidemiological evidence and common dysregulated molecular functions including glucose hypometabolism, dyslipidemias, and altered insulin signaling. High-throughput molecular profiling of the genome and transcriptome has advanced our understanding of their molecular links; however, proteomic signatures may reveal novel biomarkers and additional insights because proteins are the primary purveyors of molecular function. Herein, the contributions to our understanding of the molecular links between AD and T2D by high-throughput proteomics are reviewed. Collectively, the studies highlight strong, but broad, common molecular and metabolic signatures; however, more investigation is needed to define shared mechanisms and identify robust biomarkers and potential therapeutic targets.

DOI10.1021/acs.jproteome.5c00404
Alternate JournalJ Proteome Res
PubMed ID40622185