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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

TitleMutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Publication TypeJournal Article
Year of Publication2009
AuthorsLi Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, M Beal F, Burke RE, Li C
JournalNat Neurosci
Volume12
Issue7
Pagination826-8
Date Published2009 Jul
ISSN1546-1726
KeywordsAge Factors, Animals, Antiparkinson Agents, Apomorphine, Brain, Chromosomes, Artificial, Bacterial, Disease Models, Animal, Dopamine, Dopamine Uptake Inhibitors, Gene Transfer Techniques, Humans, Levodopa, Mice, Mice, Transgenic, Movement Disorders, Mutation, Missense, Neurons, Nomifensine, Parkinson Disease, Protein-Serine-Threonine Kinases
Abstract

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.

DOI10.1038/nn.2349
Alternate JournalNat. Neurosci.
PubMed ID19503083
PubMed Central IDPMC2845930
Grant ListP50 NS038370-09 / NS / NINDS NIH HHS / United States
P50 NS038370-090003 / NS / NINDS NIH HHS / United States
R01 NS026836-18 / NS / NINDS NIH HHS / United States