| Title | Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, M Beal F, Burke RE, Li C |
| Journal | Nat Neurosci |
| Volume | 12 |
| Issue | 7 |
| Pagination | 826-8 |
| Date Published | 2009 Jul |
| ISSN | 1546-1726 |
| Keywords | Age Factors, Animals, Antiparkinson Agents, Apomorphine, Brain, Chromosomes, Artificial, Bacterial, Disease Models, Animal, Dopamine, Dopamine Uptake Inhibitors, Gene Transfer Techniques, Humans, Levodopa, Mice, Mice, Transgenic, Movement Disorders, Mutation, Missense, Neurons, Nomifensine, Parkinson Disease, Protein-Serine-Threonine Kinases |
| Abstract | Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics. |
| DOI | 10.1038/nn.2349 |
| Alternate Journal | Nat. Neurosci. |
| PubMed ID | 19503083 |
| PubMed Central ID | PMC2845930 |
| Grant List | P50 NS038370-09 / NS / NINDS NIH HHS / United States P50 NS038370-090003 / NS / NINDS NIH HHS / United States R01 NS026836-18 / NS / NINDS NIH HHS / United States |