Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 136 results
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2026
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Bose RS, Travaglini KJ, Lam VL, Goodness D, Ta T et al..  2026.  CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. Cell. 189(5):1517-1534.e19.
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Bose RS, Travaglini KJ, Lam VL, Goodness D, Ta T et al..  2026.  CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. Cell. 189(5):1517-1534.e19.
2025
Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S et al..  2025.  Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.. Alzheimers Dement. 21(1):e14291.
Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S et al..  2025.  Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.. Alzheimers Dement. 21(1):e14291.
Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S et al..  2025.  Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.. Alzheimers Dement. 21(1):e14291.
Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung Y-F, Yang Q et al..  2025.  Brain-wide neuronal circuit connectome of human glioblastoma.. Nature. 641(8061):222-231.
Wang Z, Lipshutz A, de la Torre CMartínez, Trzeciak AJ, Liu Z-L, Miranda IC, Lazarov T, Codo AC, Romero-Pichardo JE, Nair A et al..  2025.  Early life high fructose impairs microglial phagocytosis and neurodevelopment.. Nature. 644(8077):759-768.
Wang Z, Lipshutz A, de la Torre CMartínez, Trzeciak AJ, Liu Z-L, Miranda IC, Lazarov T, Codo AC, Romero-Pichardo JE, Nair A et al..  2025.  Early life high fructose impairs microglial phagocytosis and neurodevelopment.. Nature. 644(8077):759-768.
Wang S, Qi C, Rajpurohit C, Ghosh B, Xiong W, Wang B, Qi Y, Hwang SHee, Hammock BD, Li H et al..  2025.  Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model.. Mol Neurodegener. 20(1):44.
Clelland CDudley, Fan L, Saloner R, Etchegaray JIker, Altobelli CRichard, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee S-I et al..  2025.  Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.. Commun Biol. 8(1):971.
Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S et al..  2025.  A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.. Cell Rep. 44(9):116198.
Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S et al..  2025.  A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.. Cell Rep. 44(9):116198.
Naseri NN, Xu T, Chantarawong S, Patrie SM, Kelleher NL, Sharma M, Shalem O, Rhoades E.  2025.  Specific Combinations of Physiological Tau Phosphorylation Regulate Tau-Microtubule Interactions in Developing Neurons.. bioRxiv.
2024
Grinspan ZM, Burré J, Cross J, M Ross E, Stone A, Basma N, Gao K, Kang J-Q, Lim J, Dubow E et al..  2024.  4-Phenylbutyrate for STXBP1 and SLC6A1. Safety, tolerability, seizure, and EEG outcomes. A case series at 2 centers. medRxiv.
Carling GK, Fan L, Foxe NR, Norman K, Wong MYing, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A et al..  2024.  Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. Neuron.
Carling GK, Fan L, Foxe NR, Norman K, Wong MYing, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A et al..  2024.  Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. Neuron.
Bravo CParra, Krukowski K, Barker S, Wang C, Li Y, Fan L, Vázquez-Rosa E, Shin M-K, Wong MYing, McCullough LD et al..  2024.  Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury.. Mol Neurodegener. 19(1):51.
Cheng F, Wang F, Tang J, Zhou Y, Fu Z, Zhang P, Haines JL, Leverenz JB, Gan L, Hu J et al..  2024.  Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease.. Cell Rep Med. 5(2):101379.
Rodriguez-Rodriguez P, Arroyo-Garcia LEnrique, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC et al..  2024.  A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons.. Brain. 147(7):2384-2399.
Rodriguez-Rodriguez P, Arroyo-Garcia LEnrique, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC et al..  2024.  A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons.. Brain. 147(7):2384-2399.
Zheng X, Wu B, Liu Y, Simmons SK, Kim K, Clarke GS, Ashiq A, Park J, Li J, Wang Z et al..  2024.  Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development.. Cell. 187(13):3236-3248.e21.
Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR et al..  2024.  Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.. PNAS Nexus. 3(5):pgae179.
Fridy PC, Farrell RJ, Molloy KR, Keegan S, Wang J, Jacobs EY, Li Y, Trivedi J, Sehgal V, Fenyö D et al..  2024.  A new generation of nanobody research tools using improved mass spectrometry-based discovery methods.. J Biol Chem. 300(9):107623.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.