Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

TitleRegulation of an early developmental checkpoint in the B cell pathway by Ig beta.
Publication TypeJournal Article
Year of Publication1996
AuthorsGong S, Nussenzweig MC
Date Published1996 Apr 19
KeywordsAnimals, Antigens, CD, B-Lymphocytes, CD79 Antigens, Gene Expression, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Gene Targeting, Genes, Immunoglobulin, Immunoglobulin Heavy Chains, Immunoglobulin Joining Region, Immunoglobulin Light Chains, Immunoglobulin mu-Chains, Immunoglobulin Variable Region, Lymph Nodes, Mice, Mice, Inbred C57BL, Mutation, Receptors, Antigen, B-Cell, Recombination, Genetic, RNA, Messenger, Signal Transduction

Many of the cell fate decisions in precursor B cells and more mature B cells are controlled by membrane immunoglobulin (Ig)M heavy chain (mu) and the Ig alpha-Ig beta signal transducers. The role of Ig beta in regulating early B cell development was examined in mice that lack Ig beta (Ig beta-/-). These mice had a complete block in B cell development at the immature CD43+B220+ stage. Immunoglobulin heavy chain diversity (DH) and joining (JH) segments rearranged, but variable (VH) to DJH recombination and immunoglobulin messenger RNA expression were compromised. These experiments define an unexpected, early requirement for Ig(beta) to produce B cells that can complete VDJH recombination.

Alternate JournalScience
PubMed ID8602530