Title | Sirtuins in neurodegenerative diseases: an update on potential mechanisms. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Min S-W, Sohn PD, Cho S-H, Swanson RA, Gan L |
Journal | Front Aging Neurosci |
Volume | 5 |
Pagination | 53 |
Date Published | 2013 Sep 25 |
ISSN | 1663-4365 |
Abstract | Silent information regulator 2 proteins (sirtuins or SIRTs) are a group of deacetylases (or deacylases) whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD(+)). Compelling evidence supports that sirtuins play major roles in many aspects of physiology, especially in pathways related to aging - the predominant and unifying risk factor for neurodegenerative diseases. In this review, we highlight the molecular mechanisms underlying the protective effects of sirtuins in neurodegenerative diseases, focusing on protein homeostasis, neural plasticity, mitochondrial function, and sustained chronic inflammation. We will also examine the potential and challenges of targeting sirtuin pathways to block these pathogenic pathways. |
DOI | 10.3389/fnagi.2013.00053 |
Alternate Journal | Front Aging Neurosci |
PubMed ID | 24093018 |
PubMed Central ID | PMC3782645 |
Grant List | R01 AG030207 / AG / NIA NIH HHS / United States R01 AG036884 / AG / NIA NIH HHS / United States R01 NS041421 / NS / NINDS NIH HHS / United States |