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Sirtuins in neurodegenerative diseases: an update on potential mechanisms.

TitleSirtuins in neurodegenerative diseases: an update on potential mechanisms.
Publication TypeJournal Article
Year of Publication2013
AuthorsMin S-W, Sohn PD, Cho S-H, Swanson RA, Gan L
JournalFront Aging Neurosci
Volume5
Pagination53
Date Published2013 Sep 25
ISSN1663-4365
Abstract

Silent information regulator 2 proteins (sirtuins or SIRTs) are a group of deacetylases (or deacylases) whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD(+)). Compelling evidence supports that sirtuins play major roles in many aspects of physiology, especially in pathways related to aging - the predominant and unifying risk factor for neurodegenerative diseases. In this review, we highlight the molecular mechanisms underlying the protective effects of sirtuins in neurodegenerative diseases, focusing on protein homeostasis, neural plasticity, mitochondrial function, and sustained chronic inflammation. We will also examine the potential and challenges of targeting sirtuin pathways to block these pathogenic pathways.

DOI10.3389/fnagi.2013.00053
Alternate JournalFront Aging Neurosci
PubMed ID24093018
PubMed Central IDPMC3782645
Grant ListR01 AG030207 / AG / NIA NIH HHS / United States
R01 AG036884 / AG / NIA NIH HHS / United States
R01 NS041421 / NS / NINDS NIH HHS / United States