Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.

TitleTau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.
Publication TypeJournal Article
Year of Publication2018
AuthorsTracy TE, Gan L
JournalCurr Opin Neurobiol
Date Published2018 08

The accumulation of pathological tau in the brain is associated with neuronal deterioration and cognitive impairments in tauopathies including Alzheimer's disease. Tau, while primarily localized in the axons of healthy neurons, accumulates in the soma and dendrites of neurons under pathogenic conditions. Tau is found in both presynaptic and postsynaptic compartments of neurons in Alzheimer's disease. New research supports that soluble forms of tau trigger pathophysiology in the brain by altering properties of synaptic and neuronal function at the early stages of disease progression, before neurons die. Here we review the current understanding of how tau-mediated synaptic and neuronal dysfunction contributes to cognitive decline. Delineating the mechanisms by which pathogenic tau alters synapses, dendrites and axons will help lay the foundation for new strategies that can restore neuronal function in tauopathy.

Alternate JournalCurr. Opin. Neurobiol.
PubMed ID29753269
PubMed Central IDPMC6130905
Grant ListR01 AG054214 / AG / NIA NIH HHS / United States
U54 NS100717 / NS / NINDS NIH HHS / United States