| Title | Transposable elements and Alzheimer's disease pathogenesis. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Evering TH, Marston JL, Gan L, Nixon DF |
| Journal | Trends Neurosci |
| Volume | 46 |
| Issue | 3 |
| Pagination | 170-172 |
| Date Published | 2023 Mar |
| ISSN | 1878-108X |
| Keywords | Alzheimer Disease, Amyloid beta-Peptides, DNA Transposable Elements, Humans, Microglia, Neurofibrillary Tangles, Plaque, Amyloid, tau Proteins |
| Abstract | Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis. |
| DOI | 10.1016/j.tins.2022.12.003 |
| Alternate Journal | Trends Neurosci |
| PubMed ID | 36588011 |
| Grant List | R21 AG071433 / AG / NIA NIH HHS / United States R21 NS126094 / NS / NINDS NIH HHS / United States R56 AG078970 / AG / NIA NIH HHS / United States R01 AG072758 / AG / NIA NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States |