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Found 22 results
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Ringe, Dagmar
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Ju S
,
Tardiff DF
,
Han H
,
Divya K
,
Zhong Q
,
Maquat LE
,
Bosco DA
,
Hayward LJ
,
Brown RH
,
Lindquist S
et al.
. 2011.
A yeast model of FUS/TLS-dependent cytotoxicity.
.
PLoS Biol. 9(4):e1001052.
W
Ringe D
,
Petsko GA
. 2009.
What are pharmacological chaperones and why are they interesting?
J Biol. 8(9):80.
S
Lieberman RL
,
Wustman BA
,
Huertas P
,
Powe AC
,
Pine CW
,
Khanna R
,
Schlossmacher MG
,
Ringe D
,
Petsko GA
. 2007.
Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
.
Nat Chem Biol. 3(2):101-7.
Kreinbring CA
,
Remillard SP
,
Hubbard P
,
Brodkin HR
,
Leeper FJ
,
Hawksley D
,
Lai EY
,
Fulton C
,
Petsko GA
,
Ringe D
. 2014.
Structure of a eukaryotic thiaminase I.
.
Proc Natl Acad Sci U S A. 111(1):137-42.
Auclair JR
,
Brodkin HR
,
J D'Aquino A
,
Petsko GA
,
Ringe D
,
Agar JN
. 2013.
Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase.
.
Biochemistry. 52(36):6145-50.
Das C
,
Hoang QQ
,
Kreinbring CA
,
Luchansky SJ
,
Meray RK
,
Ray SS
,
Lansbury PT
,
Ringe D
,
Petsko GA
. 2006.
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
.
Proc Natl Acad Sci U S A. 103(12):4675-80.
Auclair JR
,
Boggio KJ
,
Petsko GA
,
Ringe D
,
Agar JN
. 2010.
Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.
.
Proc Natl Acad Sci U S A. 107(50):21394-9.
Q
Sigala PA
,
Fafarman AT
,
Schwans JP
,
Fried SD
,
Fenn TD
,
Caaveiro JMM
,
Pybus B
,
Ringe D
,
Petsko GA
,
Boxer SG
et al.
. 2013.
Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.
.
Proc Natl Acad Sci U S A. 110(28):E2552-61.
P
Bosco DA
,
LaVoie MJ
,
Petsko GA
,
Ringe D
. 2011.
Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.
.
Cold Spring Harb Perspect Biol. 3(10):a007500.
Auclair JR
,
Johnson JL
,
Liu Q
,
Salisbury JP
,
Rotunno MS
,
Petsko GA
,
Ringe D
,
Brown RH
,
Bosco DA
,
Agar JN
. 2013.
Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage.
.
Biochemistry. 52(36):6137-44.
Lewandowski NM
,
Ju S
,
Verbitsky M
,
Ross B
,
Geddie ML
,
Rockenstein E
,
Adame A
,
Muhammad A
,
Vonsattel JPaul
,
Ringe D
et al.
. 2010.
Polyamine pathway contributes to the pathogenesis of Parkinson disease.
.
Proc Natl Acad Sci U S A. 107(39):16970-5.
Liu CFeng
,
Liu D
,
Momb J
,
Thomas PW
,
Lajoie A
,
Petsko GA
,
Fast W
,
Ringe D
. 2013.
A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.
.
Biochemistry. 52(9):1603-10.
Mecozzi VJ
,
Berman DE
,
Simoes S
,
Vetanovetz C
,
Awal MR
,
Patel VM
,
Schneider RT
,
Petsko GA
,
Ringe D
,
Small SA
. 2014.
Pharmacological chaperones stabilize retromer to limit APP processing.
.
Nat Chem Biol. 10(6):443-9.
Canet-Avilés RM
,
Wilson MA
,
Miller DW
,
Ahmad R
,
McLendon C
,
Bandyopadhyay S
,
Baptista MJ
,
Ringe D
,
Petsko GA
,
Cookson MR
. 2004.
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.
.
Proc Natl Acad Sci U S A. 101(24):9103-8.
M
Mattos C
,
Bellamacina CR
,
Peisach E
,
Pereira A
,
Vitkup D
,
Petsko GA
,
Ringe D
. 2006.
Multiple solvent crystal structures: probing binding sites, plasticity and hydration.
.
J Mol Biol. 357(5):1471-82.
Auclair JR
,
Somasundaran M
,
Green KM
,
Evans JE
,
Schiffer CA
,
Ringe D
,
Petsko GA
,
Agar JN
. 2012.
Mass spectrometry tools for analysis of intermolecular interactions.
.
Methods Mol Biol. 896:387-98.
L
Bharadwaj PR
,
Verdile G
,
Barr RK
,
Gupta V
,
Steele JW
,
M Lachenmayer L
,
Yue Z
,
Ehrlich ME
,
Petsko G
,
Ju S
et al.
. 2012.
Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.
.
J Alzheimers Dis. 32(4):949-67.
E
Lieberman RL
,
J D'Aquino A
,
Ringe D
,
Petsko GA
. 2009.
Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
.
Biochemistry. 48(22):4816-27.
D
Landon MR
,
Lieberman RL
,
Hoang QQ
,
Ju S
,
Caaveiro JMM
,
Orwig SD
,
Kozakov D
,
Brenke R
,
Chuang G-Y
,
Beglov D
et al.
. 2009.
Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.
.
J Comput Aided Mol Des. 23(8):491-500.
C
Edayathumangalam R
,
Wu R
,
Garcia R
,
Wang Y
,
Wang W
,
Kreinbring CA
,
Bach A
,
Liao J
,
Stone TA
,
Terwilliger TC
et al.
. 2013.
Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.
.
Proc Natl Acad Sci U S A. 110(44):17820-5.
Davies CW
,
Chaney J
,
Korbel G
,
Ringe D
,
Petsko GA
,
Ploegh H
,
Das C
. 2012.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).
.
Bioorg Med Chem Lett. 22(12):3900-4.
A
Auclair JR
,
Salisbury JP
,
Johnson JL
,
Petsko GA
,
Ringe D
,
Bosco DA
,
Agar NYR
,
Santagata S
,
Durham HD
,
Agar JN
. 2014.
Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.
.
Proteomics. 14(10):1152-7.