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Found 23 results
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Zhou, Yungui
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8
Sha SJ
,
Miller ZA
,
Min S-W
,
Zhou Y
,
Brown J
,
Mitic LL
,
Karydas A
,
Koestler M
,
Tsai R
,
Corbetta-Rastelli C
et al.
. 2017.
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from gene mutations.
.
Alzheimers Dement (N Y). 3(4):507-512.
A
Sohn PDongmin
,
Tracy TE
,
Son H-I
,
Zhou Y
,
Leite REP
,
Miller BL
,
Seeley WW
,
Grinberg LT
,
Gan L
. 2016.
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
.
Mol Neurodegener. 11(1):47.
Tracy TE
,
Sohn PDongmin
,
S Minami S
,
Wang C
,
Min S-W
,
Li Y
,
Zhou Y
,
Le D
,
Lo I
,
Ponnusamy R
et al.
. 2016.
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
.
Neuron. 90(2):245-60.
Min S-W
,
Cho S-H
,
Zhou Y
,
Schroeder S
,
Haroutunian V
,
Seeley WW
,
Huang EJ
,
Shen Y
,
Masliah E
,
Mukherjee C
et al.
. 2010.
Acetylation of tau inhibits its degradation and contributes to tauopathy.
.
Neuron. 67(6):953-66.
Sayed FA
,
Kodama L
,
Fan L
,
Carling GK
,
Udeochu JC
,
Le D
,
Li Q
,
Zhou L
,
Wong MYing
,
Horowitz R
et al.
. 2021.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
.
Sci Transl Med. 13(622):eabe3947.
Mueller-Steiner S
,
Zhou Y
,
Arai H
,
Roberson ED
,
Sun B
,
Chen J
,
Wang X
,
Yu G
,
Esposito L
,
Mucke L
et al.
. 2006.
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
.
Neuron. 51(6):703-14.
C
Wang C
,
Sun B
,
Zhou Y
,
Grubb A
,
Gan L
. 2012.
Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.
.
J Biol Chem. 287(47):39834-41.
Min S-W
,
Chen X
,
Tracy TE
,
Li Y
,
Zhou Y
,
Wang C
,
Shirakawa K
,
S Minami S
,
Defensor E
,
Mok SAnn
et al.
. 2015.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
.
Nat Med. 21(10):1154-62.
Cho S-H
,
Sun B
,
Zhou Y
,
Kauppinen TM
,
Halabisky B
,
Wes P
,
Ransohoff RM
,
Gan L
. 2011.
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
.
J Biol Chem. 286(37):32713-22.
Sun B
,
Zhou Y
,
Halabisky B
,
Lo I
,
Cho S-H
,
Mueller-Steiner S
,
Devidze N
,
Wang X
,
Grubb A
,
Gan L
. 2008.
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.
.
Neuron. 60(2):247-57.
D
Sayed FA
,
Telpoukhovskaia M
,
Kodama L
,
Li Y
,
Zhou Y
,
Le D
,
Hauduc A
,
Ludwig C
,
Gao F
,
Clelland C
et al.
. 2018.
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
.
Proc Natl Acad Sci U S A. 115(40):10172-10177.
Telpoukhovskaia MA
,
Liu K
,
Sayed FA
,
Etchegaray JIker
,
Xie M
,
Zhan L
,
Li Y
,
Zhou Y
,
Le D
,
Bahr BA
et al.
. 2020.
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
.
Sci Rep. 10(1):13688.
I
Sun B
,
Halabisky B
,
Zhou Y
,
Palop JJ
,
Yu G
,
Mucke L
,
Gan L
. 2009.
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
.
Cell Stem Cell. 5(6):624-33.
M
Zhan L
,
Fan L
,
Kodama L
,
Sohn PDongmin
,
Wong MYing
,
Mousa GAlzaem
,
Zhou Y
,
Li Y
,
Gan L
. 2020.
A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.
.
Elife. 9
Kodama L
,
Guzman E
,
Etchegaray JI
,
Li Y
,
Sayed FA
,
Zhou L
,
Zhou Y
,
Zhan L
,
Le D
,
Udeochu JC
et al.
. 2019.
Microglial microRNAs mediate sex-specific responses to tau pathology.
.
Nat Neurosci.
Wang C
,
Fan L
,
Khawaja RR
,
Liu B
,
Zhan L
,
Kodama L
,
Chin M
,
Li Y
,
Le D
,
Zhou Y
et al.
. 2022.
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
.
Nat Commun. 13(1):1969.
P
Sanchez-Mejia RO
,
Newman JW
,
Toh S
,
Yu G-Q
,
Zhou Y
,
Halabisky B
,
Cissé M
,
Scearce-Levie K
,
Cheng IH
,
Gan L
et al.
. 2008.
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
.
Nat Neurosci. 11(11):1311-8.
S Minami S
,
Min S-W
,
Krabbe G
,
Wang C
,
Zhou Y
,
Asgarov R
,
Li Y
,
Martens LH
,
Elia LP
,
Ward ME
et al.
. 2014.
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
.
Nat Med. 20(10):1157-64.
Zhan L
,
Krabbe G
,
Du F
,
Jones I
,
Reichert MC
,
Telpoukhovskaia M
,
Kodama L
,
Wang C
,
Cho S-H
,
Sayed F
et al.
. 2019.
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.
.
PLoS Biol. 17(2):e3000134.
S
S Minami S
,
Sun B
,
Popat K
,
Kauppinen T
,
Pleiss M
,
Zhou Y
,
Ward ME
,
Floreancig P
,
Mucke L
,
Desai T
et al.
. 2012.
Selective targeting of microglia by quantum dots.
.
J Neuroinflammation. 9:22.
Cho S-H
,
Chen JA
,
Sayed F
,
Ward ME
,
Gao F
,
Nguyen TA
,
Krabbe G
,
Sohn PDongmin
,
Lo I
,
Minami S
et al.
. 2015.
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.
.
J Neurosci. 35(2):807-18.
Chen J
,
Zhou Y
,
Mueller-Steiner S
,
Chen L-F
,
Kwon H
,
Yi S
,
Mucke L
,
Gan L
. 2005.
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
.
J Biol Chem. 280(48):40364-74.
T
Tracy TE
,
Madero-Pérez J
,
Swaney DL
,
Chang TS
,
Moritz M
,
Konrad C
,
Ward ME
,
Stevenson E
,
Huttenhain R
,
Kauwe G
et al.
. 2022.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
.
Cell. 185(4):712-728.e14.