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Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 25 results
Author Title Type [ Year(Desc)]
Filters: Author is Orr, Adam L  [Clear All Filters]
2008
Wang C-E, Tydlacka S, Orr AL, Yang S-H, Graham RK, Hayden MR, Li S, Chan AWS, Li X-J.  2008.  Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.. Hum Mol Genet. 17(17):2738-51.
Mastroberardino PG, Orr AL, Hu X, Na HMee, J Greenamyre T.  2008.  A FRET-based method to study protein thiol oxidation in histological preparations.. Free Radic Biol Med. 45(7):971-81.
Orr AL, Li S, Wang C-E, Li H, Wang J, Rong J, Xu X, Mastroberardino PGiorgio, J Greenamyre T, Li X-J.  2008.  N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.. J Neurosci. 28(11):2783-92.
Orr AL, Huang S, Roberts MA, Reed JC, Li S, Li X-J.  2008.  Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.. J Biol Chem. 283(23):16027-36.
2009
Orr AG, Orr AL, Li X-J, Gross RE, Traynelis SF.  2009.  Adenosine A(2A) receptor mediates microglial process retraction.. Nat Neurosci. 12(7):872-8.
2010
Li X-J, Orr AL, Li S.  2010.  Impaired mitochondrial trafficking in Huntington's disease.. Biochim Biophys Acta. 1802(1):62-5.
2011
Birket MJ, Orr AL, Gerencser AA, Madden DT, Vitelli C, Swistowski A, Brand MD, Zeng X.  2011.  A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.. J Cell Sci. 124(Pt 3):348-58.
2012
Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ et al..  2012.  Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.. Neurosci Lett. 520(1):104-9.
Quinlan CL, Orr AL, Perevoshchikova IV, Treberg JR, Ackrell BA, Brand MD.  2012.  Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions.. J Biol Chem. 287(32):27255-64.
Quinlan CL, Treberg JR, Perevoshchikova IV, Orr AL, Brand MD.  2012.  Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.. Free Radic Biol Med. 53(9):1807-17.
Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS.  2012.  Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.. J Neuroinflammation. 9:67.
Orr AL, Quinlan CL, Perevoshchikova IV, Brand MD.  2012.  A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.. J Biol Chem. 287(51):42921-35.
2013
Orr AL, Ashok D, Sarantos MR, Shi T, Hughes RE, Brand MD.  2013.  Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.. Free Radic Biol Med. 65:1047-1059.
Pranski E, Van Sanford CD, Dalal N, Orr AL, Karmali D, Cooper DS, Gearing M, Lah JJ, Levey AI, Betarbet R.  2013.  NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.. Neurosci Lett. 547:16-20.
Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Orr AL, Brand MD.  2013.  Sites of reactive oxygen species generation by mitochondria oxidizing different substrates.. Redox Biol. 1:304-12.
Perevoshchikova IV, Quinlan CL, Orr AL, Gerencser AA, Brand MD.  2013.  Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.. Free Radic Biol Med. 61:298-309.
2014
Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD.  2014.  Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.. PLoS One. 9(2):e89938.
Hey-Mogensen M, Goncalves RLS, Orr AL, Brand MD.  2014.  Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.. Free Radic Biol Med. 72:149-55.
2015
Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RLS et al..  2015.  Suppressors of superoxide production from mitochondrial complex III.. Nat Chem Biol. 11(11):834-6.
2016
Brand MD, Goncalves RLS, Orr AL, Vargas L, Gerencser AA, Jensen MBorch, Wang YT, Melov S, Turk CN, Matzen JT et al..  2016.  Suppressors of Superoxide-HO Production at Site I of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.. Cell Metab. 24(4):582-592.
2017
Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K.  2017.  Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.. Neurochem Int. 109:106-116.
Pathak D, Berthet A, Bendor JT, Yu K, Sellnow RC, Orr AL, Nguyen MK, Edwards RH, Manfredsson FP, Nakamura K.  2017.  Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.. eNeuro. 4(2)
2018
Wong H-S, Monternier P-A, Orr AL, Brand MD.  2018.  Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria.. Methods Mol Biol. 1782:287-299.
2019
Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW.  2019.  Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.. J Alzheimers Dis. 68(3):991-1011.
de Haas R, Heltzel LCMW, Tax D, van den Broek P, Steenbreker H, Verheij MMM, Russel FGM, Orr AL, Nakamura K, Smeitink JAM.  2019.  To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease.. Brain Commun. 1(1):fcz016.