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Orr AL
,
Rutaganira FU
,
de Roulet D
,
Huang EJ
,
Hertz NT
,
Shokat KM
,
Nakamura K
. 2017.
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
.
Neurochem Int. 109:106-116.
Orr AL
,
Ashok D
,
Sarantos MR
,
Shi T
,
Hughes RE
,
Brand MD
. 2013.
Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.
.
Free Radic Biol Med. 65:1047-1059.
Orr AG
,
Lo I
,
Schumacher H
,
Ho K
,
Gill M
,
Guo W
,
Kim DH
,
Knox A
,
Saito T
,
Saido TC
et al.
. 2018.
Istradefylline reduces memory deficits in aging mice with amyloid pathology.
.
Neurobiol Dis. 110:29-36.
Orr AL
,
Kim C
,
Jimenez-Morales D
,
Newton BW
,
Johnson JR
,
Krogan NJ
,
Swaney DL
,
Mahley RW
. 2019.
Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.
.
J Alzheimers Dis. 68(3):991-1011.
Orr AG
,
Orr AL
,
Li X-J
,
Gross RE
,
Traynelis SF
. 2009.
Adenosine A(2A) receptor mediates microglial process retraction.
.
Nat Neurosci. 12(7):872-8.
Orr AL
,
Ashok D
,
Sarantos MR
,
Ng R
,
Shi T
,
Gerencser AA
,
Hughes RE
,
Brand MD
. 2014.
Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.
.
PLoS One. 9(2):e89938.
Orr AL
,
Vargas L
,
Turk CN
,
Baaten JE
,
Matzen JT
,
Dardov VJ
,
Attle SJ
,
Li J
,
Quackenbush DC
,
Goncalves RLS
et al.
. 2015.
Suppressors of superoxide production from mitochondrial complex III.
.
Nat Chem Biol. 11(11):834-6.
Orr AL
,
Li S
,
Wang C-E
,
Li H
,
Wang J
,
Rong J
,
Xu X
,
Mastroberardino PGiorgio
,
J Greenamyre T
,
Li X-J
. 2008.
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
.
J Neurosci. 28(11):2783-92.
Oostrom M
,
Muniak MA
,
West RMEichler
,
Akers S
,
Pande P
,
Obiri M
,
Wang W
,
Bowyer K
,
Wu Z
,
Bramer LM
et al.
. 2024.
Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images.
.
PLoS One. 19(3):e0293856.
Oliveros G
,
Wallace CH
,
Chaudry O
,
Liu Q
,
Qiu Y
,
Xie L
,
Rockwell P
,
Figueiredo-Pereira ME
,
Serrano PA
. 2023.
Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation.
.
Brain. 146(3):898-911.
N
Nicole O
,
Goldshmidt A
,
Hamill CE
,
Sorensen SD
,
Sastre A
,
Lyuboslavsky P
,
Hepler JR
,
McKeon RJ
,
Traynelis SF
. 2005.
Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.
.
J Neurosci. 25(17):4319-29.
Netzer WJ
,
Sinha A
,
Ghias M
,
Chang E
,
Gindinova K
,
Mui E
,
Seo J-S
,
Sinha SC
. 2024.
Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP.
.
Front Chem. 12:1381205.
Naseri NN
,
Wang H
,
Guo J
,
Sharma M
,
Luo W
. 2019.
The complexity of tau in Alzheimer's disease.
.
Neurosci Lett. 705:183-194.
Naseri N
,
Sharma M
,
Velinov M
. 2020.
Autosomal dominant neuronal ceroid lipofuscinosis: Clinical features and molecular basis.
.
Clin Genet.
Naseri NN
,
Ergel B
,
Kharel P
,
Na Y
,
Huang Q
,
Huang R
,
Dolzhanskaya N
,
Burré J
,
Velinov MT
,
Sharma M
. 2020.
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
.
Nat Struct Mol Biol. 27(2):192-201.
M
Murava ALicht
,
Meadows S
,
Palaguachi F
,
Song SC
,
Bram Y
,
Zhou C
,
Schwartz RE
,
Froemke RC
,
Orr AL
,
Orr AG
. 2021.
Dementia-linked TDP-43 dysregulation in astrocytes impairs memory, antiviral signaling, and chemokine-mediated astrocytic-neuronal interactions.
.
Alzheimers Dement. 17 Suppl 2:e058562.
Mullasseril P
,
Hansen KB
,
Vance KM
,
Ogden KK
,
Yuan H
,
Kurtkaya NL
,
Santangelo R
,
Orr AG
,
Le P
,
Vellano KM
et al.
. 2010.
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.
.
Nat Commun. 1:90.
Mukherjee K
,
Sharma M
,
Urlaub H
,
Bourenkov GP
,
Jahn R
,
Südhof TC
,
Wahl MC
. 2008.
CASK Functions as a Mg2+-independent neurexin kinase.
.
Cell. 133(2):328-39.
Mukherjee K
,
Sharma M
,
Jahn R
,
Wahl MC
,
Südhof TC
. 2010.
Evolution of CASK into a Mg2+-sensitive kinase.
.
Sci Signal. 3(119):ra33.
Mueller-Steiner S
,
Zhou Y
,
Arai H
,
Roberson ED
,
Sun B
,
Chen J
,
Wang X
,
Yu G
,
Esposito L
,
Mucke L
et al.
. 2006.
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
.
Neuron. 51(6):703-14.
Muchardt C
,
Seeler JS
,
Nirula A
,
Gong S
,
Gaynor R
. 1992.
Transcription factor AP-2 activates gene expression of HTLV-I.
.
EMBO J. 11(7):2573-81.
Morciano M
,
Burré J
,
Corvey C
,
Karas M
,
Zimmermann H
,
Volknandt W
. 2005.
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
.
J Neurochem. 95(6):1732-45.
Möller T
,
Bard F
,
Bhattacharya A
,
Biber K
,
Campbell B
,
Dale E
,
Eder C
,
Gan L
,
Garden GA
,
Hughes ZA
et al.
. 2016.
Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
.
Glia. 64(10):1788-94.
S Minami S
,
Min S-W
,
Krabbe G
,
Wang C
,
Zhou Y
,
Asgarov R
,
Li Y
,
Martens LH
,
Elia LP
,
Ward ME
et al.
. 2014.
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
.
Nat Med. 20(10):1157-64.
S Minami S
,
Shen V
,
Le D
,
Krabbe G
,
Asgarov R
,
Perez-Celajes L
,
Lee C-H
,
Li J
,
Donnelly-Roberts D
,
Gan L
. 2015.
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.
.
Biochem Pharmacol. 97(4):454-462.
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