Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 442 results
[ Author(Desc)] Title Type Year
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Lee J, Kang R, Park S, Saliu IO, Son M, Voorhees JR, Dimitry JM, Quillin EI, Woodie LN, Lananna BV et al..  2025.  REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3-CD38 axis.. Nat Aging. 5(10):2070-2085.
Lee SHun, Sharma M, Südhof TC, Shen J.  2014.  Synaptic function of nicastrin in hippocampal neurons.. Proc Natl Acad Sci U S A. 111(24):8973-8.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JPaul, Ringe D et al..  2010.  Polyamine pathway contributes to the pathogenesis of Parkinson disease.. Proc Natl Acad Sci U S A. 107(39):16970-5.
Li X, Chen Y, Wang H, Zhang X, Guiberson NGuy Lewis, Li X, Burré J, Peng J, Zhang H, Yue Z.  2026.  Disruption of the LRRK2 substrate RAB12 facilitates neurotransmission and causes hyperactivity in mice.. NPJ Parkinsons Dis. 12(1)
Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S et al..  2009.  Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.. Nat Neurosci. 12(7):826-8.
Li D, Liu K, Li D, Brunger A, Li C, Burré J, Diao J.  2025.  α-Synuclein condensation in synaptic vesicle function and synucleinopathies.. Trends Cell Biol.
Li X-J, Orr AL, Li S.  2010.  Impaired mitochondrial trafficking in Huntington's disease.. Biochim Biophys Acta. 1802(1):62-5.
Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, H Koerber R et al..  2011.  The functional organization of cutaneous low-threshold mechanosensory neurons.. Cell. 147(7):1615-27.
Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SDan, Jiang X-C et al..  2004.  A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.. J Neurochem. 88(3):623-34.
Liao Z, Xie L, Mamitsuka H, Zhu S.  2023.  Sc2Mol: a scaffold-based two-step molecule generator with variational autoencoder and transformer.. Bioinformatics. 39(1)
Licht-Murava A, Meadows SM, Palaguachi F, Song SC, Jackvony S, Bram Y, Zhou C, Schwartz RE, Froemke RC, Orr AL et al..  2023.  Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.. Sci Adv. 9(16):eade1282.
Lieberman RL, Wustman BA, Huertas P, Powe AC, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA.  2007.  Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.. Nat Chem Biol. 3(2):101-7.
Lieberman RL, J D'Aquino A, Ringe D, Petsko GA.  2009.  Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.. Biochemistry. 48(22):4816-27.
Lim H, He D, Qiu Y, Krawczuk P, Sun X, Xie L.  2019.  Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology.. PLoS Comput Biol. 15(6):e1006619.
Limbad C, Oron TRonnen, Alimirah F, Davalos AR, Tracy TE, Gan L, Desprez P-Y, Campisi J.  2020.  Astrocyte senescence promotes glutamate toxicity in cortical neurons.. PLoS One. 15(1):e0227887.
Lin L-C, Nana AL, Hepker M, Hwang J-HLee, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH et al..  2019.  Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.. Acta Neuropathol Commun. 7(1):159.
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S.  2014.  Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.. Neuropharmacology. 85:232-42.
Liu Q, Lee B, Xie L.  2022.  Small molecule modulation of microbiota: a systems pharmacology perspective.. BMC Bioinformatics. 23(Suppl 3):403.
Liu Y, Lim H, Xie L.  2022.  Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding.. BMC Bioinformatics. 23(Suppl 3):158.
Liu CFeng, Liu D, Momb J, Thomas PW, Lajoie A, Petsko GA, Fast W, Ringe D.  2013.  A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.. Biochemistry. 52(9):1603-10.
Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al..  2023.  Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.
Liu Y, Feng W, Aikedan A, Lee S-I, Bhagwat M, Nagiri RKumar, Wong MYing, Amin S, Qu W, Zhu J et al..  2026.  cGAS inhibition delays TDP-43-driven ALS Pathogenesis.. bioRxiv.
Liu Q, He D, Xie L.  2019.  Prediction of off-target specificity and cell-specific fitness of CRISPR-Cas System using attention boosted deep learning and network-based gene feature.. PLoS Comput Biol. 15(10):e1007480.
Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al..  2024.  Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.. Nat Commun. 15(1):10269.
Liu W, Acín-Peréz R, Geghman KD, Manfredi G, Lu B, Li C.  2011.  Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.. Proc Natl Acad Sci U S A. 108(31):12920-4.