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2018
Min S-W
,
Sohn PDongmin
,
Li Y
,
Devidze N
,
Johnson JR
,
Krogan NJ
,
Masliah E
,
Mok S-A
,
Gestwicki JE
,
Gan L
. 2018.
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
.
J Neurosci. 38(15):3680-3688.
2019
Song M
,
Yang X
,
Ren X
,
Maliskova L
,
Li B
,
Jones IR
,
Wang C
,
Jacob F
,
Wu K
,
Traglia M
et al.
. 2019.
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
.
Nat Genet. 51(8):1252-1262.
Zhan L
,
Krabbe G
,
Du F
,
Jones I
,
Reichert MC
,
Telpoukhovskaia M
,
Kodama L
,
Wang C
,
Cho S-H
,
Sayed F
et al.
. 2019.
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.
.
PLoS Biol. 17(2):e3000134.
de Haas R
,
Heltzel LCMW
,
Tax D
,
van den Broek P
,
Steenbreker H
,
Verheij MMM
,
Russel FGM
,
Orr AL
,
Nakamura K
,
Smeitink JAM
. 2019.
To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease.
.
Brain Commun. 1(1):fcz016.
2020
Wong MYing
,
Lewis M
,
Doherty JJ
,
Shi Y
,
Cashikar AG
,
Amelianchik A
,
Tymchuk S
,
Sullivan PM
,
Qian M
,
Covey DF
et al.
. 2020.
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
.
J Neuroinflammation. 17(1):192.
Naseri NN
,
Ergel B
,
Kharel P
,
Na Y
,
Huang Q
,
Huang R
,
Dolzhanskaya N
,
Burré J
,
Velinov MT
,
Sharma M
. 2020.
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
.
Nat Struct Mol Biol. 27(2):192-201.
Limbad C
,
Oron TRonnen
,
Alimirah F
,
Davalos AR
,
Tracy TE
,
Gan L
,
Desprez P-Y
,
Campisi J
. 2020.
Astrocyte senescence promotes glutamate toxicity in cortical neurons.
.
PLoS One. 15(1):e0227887.
Limbad C
,
Oron TRonnen
,
Alimirah F
,
Davalos AR
,
Tracy TE
,
Gan L
,
Desprez P-Y
,
Campisi J
. 2020.
Astrocyte senescence promotes glutamate toxicity in cortical neurons.
.
PLoS One. 15(1):e0227887.
Telpoukhovskaia MA
,
Liu K
,
Sayed FA
,
Etchegaray JIker
,
Xie M
,
Zhan L
,
Li Y
,
Zhou Y
,
Le D
,
Bahr BA
et al.
. 2020.
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
.
Sci Rep. 10(1):13688.
Inda MCarmen
,
Joshi S
,
Wang T
,
Bolaender A
,
Gandu S
,
Iii JKoren
,
Che AYue
,
Taldone T
,
Yan P
,
Sun W
et al.
. 2020.
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
.
Nat Commun. 11(1):319.
Inda MCarmen
,
Joshi S
,
Wang T
,
Bolaender A
,
Gandu S
,
Iii JKoren
,
Che AYue
,
Taldone T
,
Yan P
,
Sun W
et al.
. 2020.
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
.
Nat Commun. 11(1):319.
Kumar S
,
Singh SKumar
,
Viswakarma N
,
Sondarva G
,
Nair RSathish
,
Sethupathi P
,
Sinha SC
,
Emmadi R
,
Hoskins K
,
Danciu O
et al.
. 2020.
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
.
Proc Natl Acad Sci U S A. 117(14):7961-7970.
Kumar S
,
Singh SKumar
,
Viswakarma N
,
Sondarva G
,
Nair RSathish
,
Sethupathi P
,
Dorman M
,
Sinha SC
,
Hoskins K
,
Thatcher G
et al.
. 2020.
Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8 T cells.
.
J Immunother Cancer. 8(2)
Abramov D
,
Guiberson NGuy Lewis
,
Daab A
,
Na Y
,
Petsko GA
,
Sharma M
,
Burré J
. 2020.
Targeted stabilization of Munc18-1 function via pharmacological chaperones.
.
EMBO Mol Med. :e12354.
2021
Caballero B
,
Bourdenx M
,
Luengo E
,
Diaz A
,
Sohn PDongmin
,
Chen X
,
Wang C
,
Juste YR
,
Wegmann S
,
Patel B
et al.
. 2021.
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
.
Nat Commun. 12(1):2238.
Sayed FA
,
Kodama L
,
Fan L
,
Carling GK
,
Udeochu JC
,
Le D
,
Li Q
,
Zhou L
,
Wong MYing
,
Horowitz R
et al.
. 2021.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
.
Sci Transl Med. 13(622):eabe3947.
Sayed FA
,
Kodama L
,
Fan L
,
Carling GK
,
Udeochu JC
,
Le D
,
Li Q
,
Zhou L
,
Wong MYing
,
Horowitz R
et al.
. 2021.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
.
Sci Transl Med. 13(622):eabe3947.
Singh SKumar
,
Kumar S
,
Viswakarma N
,
Principe DR
,
Das S
,
Sondarva G
,
Nair RSathish
,
Srivastava P
,
Sinha SC
,
Grippo PJ
et al.
. 2021.
MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3.
.
Oncogene. 40(43):6153-6165.
Viswakarma N
,
Sondarva G
,
Principe DR
,
Nair RSathish
,
Kumar S
,
Singh SKumar
,
Das S
,
Sinha SC
,
Grippo PJ
,
Grimaldo S
et al.
. 2021.
Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.
.
Cancer Lett. 515:1-13.
Du H
,
Wong MYing
,
Zhang T
,
Santos MNunez
,
Hsu C
,
Zhang J
,
Yu H
,
Luo W
,
Hu F
. 2021.
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.
.
Life Sci Alliance. 4(7)
Shin M-K
,
Vázquez-Rosa E
,
Koh Y
,
Dhar M
,
Chaubey K
,
Cintrón-Pérez CJ
,
Barker S
,
Miller E
,
Franke K
,
Noterman MF
et al.
. 2021.
Reducing acetylated tau is neuroprotective in brain injury.
.
Cell.
2022
Dräger NM
,
Sattler SM
,
Huang CTzu-Ling
,
Teter OM
,
Leng K
,
Hashemi SHadi
,
Hong J
,
Aviles G
,
Clelland CD
,
Zhan L
et al.
. 2022.
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
.
Nat Neurosci.
Dong Q
,
Gentry NW
,
McMahon T
,
Yamazaki M
,
Benitez-Rivera L
,
Wang T
,
Gan L
,
Ptáček L
,
Fu Y-H
. 2022.
Familial natural short sleep mutations reduce Alzheimer pathology in mice.
.
iScience. 25(4):103964.
Kuo S-H
,
Tasset I
,
Cheng MM
,
Diaz A
,
Pan M-K
,
Lieberman OJ
,
Hutten SJ
,
Alcalay RN
,
Kim S
,
Ximénez-Embún P
et al.
. 2022.
Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
.
Sci Adv. 8(6):eabm6393.
Xia D
,
Lianoglou S
,
Sandmann T
,
Calvert M
,
Suh JH
,
Thomsen E
,
Dugas J
,
Pizzo ME
,
DeVos SL
,
Earr TK
et al.
. 2022.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
.
Mol Neurodegener. 17(1):41.
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