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Found 137 results
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2012
Davies CW
,
Chaney J
,
Korbel G
,
Ringe D
,
Petsko GA
,
Ploegh H
,
Das C
. 2012.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).
.
Bioorg Med Chem Lett. 22(12):3900-4.
Pranski EL
,
Van Sanford CD
,
Dalal NV
,
Orr AL
,
Karmali D
,
Cooper DS
,
Costa N
,
Heilman CJ
,
Gearing M
,
Lah JJ
et al.
. 2012.
Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.
.
Neurosci Lett. 520(1):104-9.
Hunter JM
,
Cirrito JR
,
Restivo JL
,
Kinley RD
,
Sullivan PM
,
Holtzman DM
,
Koger D
,
DeLong C
,
Lin S
,
Zhao L
et al.
. 2012.
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
.
Brain Res. 1467:120-32.
Sanchez PE
,
Zhu L
,
Verret L
,
Vossel KA
,
Orr AG
,
Cirrito JR
,
Devidze N
,
Ho K
,
Yu G-Q
,
Palop JJ
et al.
. 2012.
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.
.
Proc Natl Acad Sci U S A. 109(42):E2895-903.
Pranski EL
,
Dalal NV
,
Herskowitz JH
,
Orr AL
,
Roesch LA
,
Fritz JJ
,
Heilman C
,
Lah JJ
,
Levey AI
,
Betarbet RS
. 2012.
Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.
.
J Neuroinflammation. 9:67.
S Minami S
,
Sun B
,
Popat K
,
Kauppinen T
,
Pleiss M
,
Zhou Y
,
Ward ME
,
Floreancig P
,
Mucke L
,
Desai T
et al.
. 2012.
Selective targeting of microglia by quantum dots.
.
J Neuroinflammation. 9:22.
2011
Castellano JM
,
Kim J
,
Stewart FR
,
Jiang H
,
DeMattos RB
,
Patterson BW
,
Fagan AM
,
Morris JC
,
Mawuenyega KG
,
Cruchaga C
et al.
. 2011.
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
.
Sci Transl Med. 3(89):89ra57.
Witten IB
,
Steinberg EE
,
Lee SYeun
,
Davidson TJ
,
Zalocusky KA
,
Brodsky M
,
Yizhar O
,
Cho SL
,
Gong S
,
Ramakrishnan C
et al.
. 2011.
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.
.
Neuron. 72(5):721-33.
Witten IB
,
Steinberg EE
,
Lee SYeun
,
Davidson TJ
,
Zalocusky KA
,
Brodsky M
,
Yizhar O
,
Cho SL
,
Gong S
,
Ramakrishnan C
et al.
. 2011.
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.
.
Neuron. 72(5):721-33.
Cissé M
,
Halabisky B
,
Harris J
,
Devidze N
,
Dubal DB
,
Sun B
,
Orr A
,
Lotz G
,
Kim DH
,
Hamto P
et al.
. 2011.
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
.
Nature. 469(7328):47-52.
Cissé M
,
Halabisky B
,
Harris J
,
Devidze N
,
Dubal DB
,
Sun B
,
Orr A
,
Lotz G
,
Kim DH
,
Hamto P
et al.
. 2011.
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
.
Nature. 469(7328):47-52.
Ju S
,
Tardiff DF
,
Han H
,
Divya K
,
Zhong Q
,
Maquat LE
,
Bosco DA
,
Hayward LJ
,
Brown RH
,
Lindquist S
et al.
. 2011.
A yeast model of FUS/TLS-dependent cytotoxicity.
.
PLoS Biol. 9(4):e1001052.
2010
Paul SM
,
Mytelka DS
,
Dunwiddie CT
,
Persinger CC
,
Munos BH
,
Lindborg SR
,
Schacht AL
. 2010.
How to improve R&D productivity: the pharmaceutical industry's grand challenge.
.
Nat Rev Drug Discov. 9(3):203-14.
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
Vives-Bauza C
,
Zhou C
,
Huang Y
,
Cui M
,
de Vries RLA
,
Kim J
,
May J
,
Tocilescu MAleksandra
,
Liu W
,
Ko HSeok
et al.
. 2010.
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
.
Proc Natl Acad Sci U S A. 107(1):378-83.
Vives-Bauza C
,
Zhou C
,
Huang Y
,
Cui M
,
de Vries RLA
,
Kim J
,
May J
,
Tocilescu MAleksandra
,
Liu W
,
Ko HSeok
et al.
. 2010.
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
.
Proc Natl Acad Sci U S A. 107(1):378-83.
Vives-Bauza C
,
Zhou C
,
Huang Y
,
Cui M
,
de Vries RLA
,
Kim J
,
May J
,
Tocilescu MAleksandra
,
Liu W
,
Ko HSeok
et al.
. 2010.
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
.
Proc Natl Acad Sci U S A. 107(1):378-83.
Siemers ER
,
Friedrich S
,
Dean RA
,
Gonzales CR
,
Farlow MR
,
Paul SM
,
DeMattos RB
. 2010.
Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.
.
Clin Neuropharmacol. 33(2):67-73.
Siemers ER
,
Friedrich S
,
Dean RA
,
Gonzales CR
,
Farlow MR
,
Paul SM
,
DeMattos RB
. 2010.
Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.
.
Clin Neuropharmacol. 33(2):67-73.
2009
Lieberman RL
,
J D'Aquino A
,
Ringe D
,
Petsko GA
. 2009.
Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
.
Biochemistry. 48(22):4816-27.
Bateman RJ
,
Siemers ER
,
Mawuenyega KG
,
Wen G
,
Browning KR
,
Sigurdson WC
,
Yarasheski KE
,
Friedrich SW
,
DeMattos RB
,
May PC
et al.
. 2009.
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.
.
Ann Neurol. 66(1):48-54.
Bales KR
,
Liu F
,
Wu S
,
Lin S
,
Koger D
,
DeLong C
,
Hansen JC
,
Sullivan PM
,
Paul SM
. 2009.
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
.
J Neurosci. 29(21):6771-9.
Zhao L
,
Lin S
,
Bales KR
,
Gelfanova V
,
Koger D
,
DeLong C
,
Hale J
,
Liu F
,
Hunter JM
,
Paul SM
. 2009.
Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.
.
J Neurosci. 29(11):3603-12.
2008
Doyle JP
,
Dougherty JD
,
Heiman M
,
Schmidt EF
,
Stevens TR
,
Ma G
,
Bupp S
,
Shrestha P
,
Shah RD
,
Doughty ML
et al.
. 2008.
Application of a translational profiling approach for the comparative analysis of CNS cell types.
.
Cell. 135(4):749-62.
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