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Found 173 results
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2018
A Willsey J
,
Morris MT
,
Wang S
,
Willsey HR
,
Sun N
,
Teerikorpi N
,
Baum TB
,
Cagney G
,
Bender KJ
,
Desai TA
et al.
. 2018.
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
.
Cell. 174(3):505-520.
Gupta I
,
Collier PG
,
Haase B
,
Mahfouz A
,
Joglekar A
,
Floyd T
,
Koopmans F
,
Barres B
,
Smit AB
,
Sloan SA
et al.
. 2018.
Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells.
.
Nat Biotechnol.
Min S-W
,
Sohn PDongmin
,
Li Y
,
Devidze N
,
Johnson JR
,
Krogan NJ
,
Masliah E
,
Mok S-A
,
Gestwicki JE
,
Gan L
. 2018.
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
.
J Neurosci. 38(15):3680-3688.
2017
Sha SJ
,
Miller ZA
,
Min S-W
,
Zhou Y
,
Brown J
,
Mitic LL
,
Karydas A
,
Koestler M
,
Tsai R
,
Corbetta-Rastelli C
et al.
. 2017.
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from gene mutations.
.
Alzheimers Dement (N Y). 3(4):507-512.
Sha SJ
,
Miller ZA
,
Min S-W
,
Zhou Y
,
Brown J
,
Mitic LL
,
Karydas A
,
Koestler M
,
Tsai R
,
Corbetta-Rastelli C
et al.
. 2017.
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from gene mutations.
.
Alzheimers Dement (N Y). 3(4):507-512.
Boselli M
,
Lee B-H
,
Robert J
,
Prado MA
,
Min S-W
,
Cheng C
,
M Silva C
,
Seong C
,
Elsasser S
,
Hatle KM
et al.
. 2017.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
.
J Biol Chem. 292(47):19209-19225.
Krabbe G
,
S Minami S
,
Etchegaray JI
,
Taneja P
,
Djukic B
,
Davalos D
,
Le D
,
Lo I
,
Zhan L
,
Reichert MC
et al.
. 2017.
Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
.
Proc Natl Acad Sci U S A. 114(19):5029-5034.
Wang C
,
Ward ME
,
Chen R
,
Liu K
,
Tracy TE
,
Chen X
,
Xie M
,
Sohn PDongmin
,
Ludwig C
,
Meyer-Franke A
et al.
. 2017.
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.
.
Stem Cell Reports. 9(4):1221-1233.
Krencik R
,
Seo K
,
van Asperen JV
,
Basu N
,
Cvetkovic C
,
Barlas S
,
Chen R
,
Ludwig C
,
Wang C
,
Ward ME
et al.
. 2017.
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
.
Stem Cell Reports. 9(6):1745-1753.
2016
Zhao L
,
Gottesdiener AJ
,
Parmar M
,
Li M
,
Kaminsky SM
,
Chiuchiolo MJ
,
Sondhi D
,
Sullivan PM
,
Holtzman DM
,
Crystal RG
et al.
. 2016.
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
.
Neurobiol Aging. 44:159-72.
Yuan P
,
Condello C
,
C Keene D
,
Wang Y
,
Bird TD
,
Paul SM
,
Luo W
,
Colonna M
,
Baddeley D
,
Grutzendler J
. 2016.
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
.
Neuron. 90(4):724-39.
Yuan P
,
Condello C
,
C Keene D
,
Wang Y
,
Bird TD
,
Paul SM
,
Luo W
,
Colonna M
,
Baddeley D
,
Grutzendler J
. 2016.
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
.
Neuron. 92(1):252-264.
2015
Orr AG
,
Hsiao EC
,
Wang MM
,
Ho K
,
Kim DH
,
Wang X
,
Guo W
,
Kang J
,
Yu G-Q
,
Adame A
et al.
. 2015.
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
.
Nat Neurosci. 18(3):423-34.
Orr AG
,
Hsiao EC
,
Wang MM
,
Ho K
,
Kim DH
,
Wang X
,
Guo W
,
Kang J
,
Yu G-Q
,
Adame A
et al.
. 2015.
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
.
Nat Neurosci. 18(3):423-34.
Kember RL
,
Georgi B
,
Bailey-Wilson JE
,
Stambolian D
,
Paul SM
,
Bućan M
. 2015.
Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder.
.
BMC Genet. 16:27.
Min S-W
,
Chen X
,
Tracy TE
,
Li Y
,
Zhou Y
,
Wang C
,
Shirakawa K
,
S Minami S
,
Defensor E
,
Mok SAnn
et al.
. 2015.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
.
Nat Med. 21(10):1154-62.
S Minami S
,
Shen V
,
Le D
,
Krabbe G
,
Asgarov R
,
Perez-Celajes L
,
Lee C-H
,
Li J
,
Donnelly-Roberts D
,
Gan L
. 2015.
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.
.
Biochem Pharmacol. 97(4):454-462.
Cho S-H
,
Chen JA
,
Sayed F
,
Ward ME
,
Gao F
,
Nguyen TA
,
Krabbe G
,
Sohn PDongmin
,
Lo I
,
Minami S
et al.
. 2015.
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.
.
J Neurosci. 35(2):807-18.
Kim KHye
,
Liu J
,
Galvin RJSells
,
Dage JL
,
Egeland JA
,
Smith RC
,
Merchant KM
,
Paul SM
. 2015.
Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree.
.
PLoS One. 10(11):e0142693.
2014
Fargo KN
,
Aisen P
,
Albert M
,
Au R
,
Corrada MM
,
DeKosky S
,
Drachman D
,
Fillit H
,
Gitlin L
,
Haas M
et al.
. 2014.
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
.
Alzheimers Dement. 10(5 Suppl):S430-52.
Fargo KN
,
Aisen P
,
Albert M
,
Au R
,
Corrada MM
,
DeKosky S
,
Drachman D
,
Fillit H
,
Gitlin L
,
Haas M
et al.
. 2014.
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
.
Alzheimers Dement. 10(5 Suppl):S430-52.
Fargo KN
,
Aisen P
,
Albert M
,
Au R
,
Corrada MM
,
DeKosky S
,
Drachman D
,
Fillit H
,
Gitlin L
,
Haas M
et al.
. 2014.
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
.
Alzheimers Dement. 10(5 Suppl):S430-52.
Fargo KN
,
Aisen P
,
Albert M
,
Au R
,
Corrada MM
,
DeKosky S
,
Drachman D
,
Fillit H
,
Gitlin L
,
Haas M
et al.
. 2014.
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
.
Alzheimers Dement. 10(5 Suppl):S430-52.
Fargo KN
,
Aisen P
,
Albert M
,
Au R
,
Corrada MM
,
DeKosky S
,
Drachman D
,
Fillit H
,
Gitlin L
,
Haas M
et al.
. 2014.
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
.
Alzheimers Dement. 10(5 Suppl):S430-52.
Fargo KN
,
Aisen P
,
Albert M
,
Au R
,
Corrada MM
,
DeKosky S
,
Drachman D
,
Fillit H
,
Gitlin L
,
Haas M
et al.
. 2014.
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
.
Alzheimers Dement. 10(5 Suppl):S430-52.
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