Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 286 results
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2025
Khawaja RR, Griego E, Lindenau K, Salek A, Gambardella J, Scrivo A, Monday HR, Bourdenx M, Madero-Pérez J, Khan ZN et al..  2025.  Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome.. Nat Cell Biol. 27(10):1688-1707.
Khawaja RR, Griego E, Lindenau K, Salek A, Gambardella J, Scrivo A, Monday HR, Bourdenx M, Madero-Pérez J, Khan ZN et al..  2025.  Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome.. Nat Cell Biol. 27(10):1688-1707.
Khawaja RR, Griego E, Lindenau K, Salek A, Gambardella J, Scrivo A, Monday HR, Bourdenx M, Madero-Pérez J, Khan ZN et al..  2025.  Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome.. Nat Cell Biol. 27(10):1688-1707.
Khawaja RR, Griego E, Lindenau K, Salek A, Gambardella J, Scrivo A, Monday HR, Bourdenx M, Madero-Pérez J, Khan ZN et al..  2025.  Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome.. Nat Cell Biol. 27(10):1688-1707.
Hu W, Foord C, Hsu J, Fan L, Corley MJ, Lanjewar SN, Xu S, Belchikov N, He Y, Pang APS et al..  2025.  Combined single-cell profiling of chromatin-transcriptome and splicing across brain cell types, regions and disease state.. Nat Biotechnol.
Gao V, Crawford CV, Burré J.  2025.  Corrigendum: The Gut-Brain Axis in Parkinson's Disease.. Cold Spring Harb Perspect Med.
Chen H, Fan L, Guo Q, Wong MYing, Zhu J, Foxe N, Wang W, Nessim A, Carling G, Liu B et al..  2025.  DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice.. Mol Neurodegener. 20(1):124.
Chen H, Fan L, Guo Q, Wong MYing, Zhu J, Foxe N, Wang W, Nessim A, Carling G, Liu B et al..  2025.  DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice.. Mol Neurodegener. 20(1):124.
Wang Z, Lipshutz A, de la Torre CMartínez, Trzeciak AJ, Liu Z-L, Miranda IC, Lazarov T, Codo AC, Romero-Pichardo JE, Nair A et al..  2025.  Early life high fructose impairs microglial phagocytosis and neurodevelopment.. Nature. 644(8077):759-768.
Chen TN, Orr AL, Orr AG, Vacanti NM.  2025.  Identifying Links between Alzheimer's Disease and Type 2 Diabetes through Proteomics.. J Proteome Res. 24(8):3733-3740.
Ju H, Kim I-D, Pavlova I, Mu S, Park KWoo, Minkler J, Madkoor A, Wang W, Wang X, Wu Z et al..  2025.  Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis.. Circ Res. 136(5):e34-e51.
Ju H, Kim I-D, Pavlova I, Mu S, Park KWoo, Minkler J, Madkoor A, Wang W, Wang X, Wu Z et al..  2025.  Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis.. Circ Res. 136(5):e34-e51.
Barnett D, Zimmer TS, Booraem C, Palaguachi F, Meadows SM, Xiao H, Wong MYing, Luo W, Gan L, Chouchani ET et al..  2025.  Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology.. Nat Metab. 7(11):2300-2323.
Clelland CDudley, Fan L, Saloner R, Etchegaray JIker, Altobelli CRichard, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee S-I et al..  2025.  Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.. Commun Biol. 8(1):971.
Clelland CDudley, Fan L, Saloner R, Etchegaray JIker, Altobelli CRichard, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee S-I et al..  2025.  Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.. Commun Biol. 8(1):971.
Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S et al..  2025.  A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.. Cell Rep. 44(9):116198.
Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S et al..  2025.  A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.. Cell Rep. 44(9):116198.
Naseri NN, Xu T, Chantarawong S, Patrie SM, Kelleher NL, Sharma M, Shalem O, Rhoades E.  2025.  Specific Combinations of Physiological Tau Phosphorylation Regulate Tau-Microtubule Interactions in Developing Neurons.. bioRxiv.
Chen H, Fan L, Wong MYing, Ambaw YA, Zhu J, Norman K, Ye P, Foxe N, Zhu D, Wan Y et al..  2025.  STING-IFN-CH25H lipid axis links innate immune activation to tau pathology.. bioRxiv.
Gao V, Chlebowicz J, Gaskin K, Briano JA, Komer LE, Pineda A, Jhalani S, Ahmad S, Uwaifo E, Black LS et al..  2025.  Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy.. Nat Commun. 16(1):4079.
2024
Grinspan ZM, Burré J, Cross J, M Ross E, Stone A, Basma N, Gao K, Kang J-Q, Lim J, Dubow E et al..  2024.  4-Phenylbutyrate for STXBP1 and SLC6A1. Safety, tolerability, seizure, and EEG outcomes. A case series at 2 centers. medRxiv.
Bhatti DL, Jin J, Cheng J, McCabe K, Lee K-W, Berdasco C, Jeong YYoung, Sinha SC, Kim Y.  2024.  Ahnak in the prefrontal cortex mediates behavioral correlates of stress resilience and rapid antidepressant action in mice.. Front Mol Neurosci. 17:1350716.
Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MYing, Zhu D, Yu F, Xu J, Yarahmady A et al..  2024.  Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. bioRxiv.
Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MYing, Zhu D, Yu F, Xu J, Yarahmady A et al..  2024.  Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. bioRxiv.
Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MYing, Zhu D, Yu F, Xu J, Yarahmady A et al..  2024.  Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. bioRxiv.