Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 36 results
Author Title Type [ Year(Desc)]
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1996
Gan L, Perney TM, Kaczmarek LK.  1996.  Cloning and characterization of the promoter for a potassium channel expressed in high frequency firing neurons.. J Biol Chem. 271(10):5859-65.
Gong S, Sanchez M, Nussenzweig MC.  1996.  Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta.. J Exp Med. 184(6):2079-84.
1998
Wang LY, Gan L, Forsythe ID, Kaczmarek LK.  1998.  Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones.. J Physiol. 509 ( Pt 1):183-94.
1999
Gan L, Hahn SJ, Kaczmarek LK.  1999.  Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter.. J Neurochem. 73(4):1350-62.
2000
Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG.  2000.  The catalytic pathway of cytochrome p450cam at atomic resolution.. Science. 287(5458):1615-22.
2001
Sharma M, Benharouga M, Hu W, Lukacs GL.  2001.  Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.. J Biol Chem. 276(12):8942-50.
2002
Benharouga M, Sharma M, Lukacs GL.  2002.  CFTR folding and maturation in cells.. Methods Mol Med. 70:229-43.
DeMattos RB, O'dell MA, Parsadanian M, Taylor JW, Harmony JAK, Bales KR, Paul SM, Aronow BJ, Holtzman DM.  2002.  Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 99(16):10843-8.
2006
Bales KR, Tzavara ET, Wu S, Wade MR, Bymaster FP, Paul SM, Nomikos GG.  2006.  Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody.. J Clin Invest. 116(3):825-32.
2008
Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC.  2008.  CASK Functions as a Mg2+-independent neurexin kinase.. Cell. 133(2):328-39.
Bateup HS, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N, Greengard P.  2008.  Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs.. Nat Neurosci. 11(8):932-9.
Sun B, Zhou Y, Halabisky B, Lo I, Cho S-H, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L.  2008.  Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.. Neuron. 60(2):247-57.
2011
Sharma M, Burré J, Südhof TC.  2011.  CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.. Nat Cell Biol. 13(1):30-9.
Cho S-H, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L.  2011.  CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.. J Biol Chem. 286(37):32713-22.
2012
Wang C, Sun B, Zhou Y, Grubb A, Gan L.  2012.  Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.. J Biol Chem. 287(47):39834-41.
Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C.  2012.  The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).. Bioorg Med Chem Lett. 22(12):3900-4.
Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ et al..  2012.  Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.. Neurosci Lett. 520(1):104-9.
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC.  2012.  CSPα knockout causes neurodegeneration by impairing SNAP-25 function.. EMBO J. 31(4):829-41.
2013
Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC et al..  2013.  Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.. Proc Natl Acad Sci U S A. 110(44):17820-5.
Wu X, Gong S, Roy-Burman P, Lee P, Culig Z.  2013.  Current mouse and cell models in prostate cancer research.. Endocr Relat Cancer. 20(4):R155-70.
2015
Kember RL, Georgi B, Bailey-Wilson JE, Stambolian D, Paul SM, Bućan M.  2015.  Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder.. BMC Genet. 16:27.
Min S-W, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, S Minami S, Defensor E, Mok SAnn et al..  2015.  Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.. Nat Med. 21(10):1154-62.
2016
Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA et al..  2016.  Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.. Glia. 64(10):1788-94.
2018
Burré J, Sharma M, Südhof TC.  2018.  Cell Biology and Pathophysiology of α-Synuclein.. Cold Spring Harb Perspect Med. 8(3)
Gan L, Cookson MR, Petrucelli L, La Spada AR.  2018.  Converging pathways in neurodegeneration, from genetics to mechanisms.. Nat Neurosci. 21(10):1300-1309.