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Found 93 results
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8
Sha SJ
,
Miller ZA
,
Min S-W
,
Zhou Y
,
Brown J
,
Mitic LL
,
Karydas A
,
Koestler M
,
Tsai R
,
Corbetta-Rastelli C
et al.
. 2017.
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from gene mutations.
.
Alzheimers Dement (N Y). 3(4):507-512.
A
Sohn PDongmin
,
Tracy TE
,
Son H-I
,
Zhou Y
,
Leite REP
,
Miller BL
,
Seeley WW
,
Grinberg LT
,
Gan L
. 2016.
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
.
Mol Neurodegener. 11(1):47.
Tracy TE
,
Gan L
. 2017.
Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.
.
Bioessays. 39(4)
Caballero B
,
Bourdenx M
,
Luengo E
,
Diaz A
,
Sohn PDongmin
,
Chen X
,
Wang C
,
Juste YR
,
Wegmann S
,
Patel B
et al.
. 2021.
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
.
Nat Commun. 12(1):2238.
Tracy TE
,
Sohn PDongmin
,
S Minami S
,
Wang C
,
Min S-W
,
Li Y
,
Zhou Y
,
Le D
,
Lo I
,
Ponnusamy R
et al.
. 2016.
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
.
Neuron. 90(2):245-60.
Min S-W
,
Cho S-H
,
Zhou Y
,
Schroeder S
,
Haroutunian V
,
Seeley WW
,
Huang EJ
,
Shen Y
,
Masliah E
,
Mukherjee C
et al.
. 2010.
Acetylation of tau inhibits its degradation and contributes to tauopathy.
.
Neuron. 67(6):953-66.
Luo W
,
Qu W
,
Gan L
. 2023.
The AD odyssey 2023: Tales of single cell.
.
Cell. 186(20):4257-4259.
Sayed FA
,
Kodama L
,
Fan L
,
Carling GK
,
Udeochu JC
,
Le D
,
Li Q
,
Zhou L
,
Wong MYing
,
Horowitz R
et al.
. 2021.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
.
Sci Transl Med. 13(622):eabe3947.
Das M
,
Mao W
,
Voskobiynyk Y
,
Necula D
,
Lew I
,
Petersen C
,
Zahn A
,
Yu G-Q
,
Yu X
,
Smith N
et al.
. 2023.
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.
.
Neurobiol Dis. 186:106263.
Bravo CParra
,
Krukowski K
,
Barker S
,
Wang C
,
Li Y
,
Fan L
,
Vázquez-Rosa E
,
Shin M-K
,
Wong MYing
,
McCullough LD
et al.
. 2024.
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury.
.
Mol Neurodegener. 19(1):51.
Mueller-Steiner S
,
Zhou Y
,
Arai H
,
Roberson ED
,
Sun B
,
Chen J
,
Wang X
,
Yu G
,
Esposito L
,
Mucke L
et al.
. 2006.
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
.
Neuron. 51(6):703-14.
Grinberg LTenenholz
,
Wang X
,
Wang C
,
Sohn PDongmin
,
Theofilas P
,
Sidhu M
,
Arevalo JBenjamin
,
Heinsen H
,
Huang EJ
,
Rosen H
et al.
. 2013.
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.
.
Acta Neuropathol. 125(4):581-93.
Limbad C
,
Oron TRonnen
,
Alimirah F
,
Davalos AR
,
Tracy TE
,
Gan L
,
Desprez P-Y
,
Campisi J
. 2020.
Astrocyte senescence promotes glutamate toxicity in cortical neurons.
.
PLoS One. 15(1):e0227887.
Amin S
,
Liu B
,
Gan L
. 2023.
Autophagy prevents microglial senescence.
.
Nat Cell Biol. 25(7):923-925.
C
Wang C
,
Sun B
,
Zhou Y
,
Grubb A
,
Gan L
. 2012.
Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.
.
J Biol Chem. 287(47):39834-41.
Karch CM
,
Kao AW
,
Karydas A
,
Onanuga K
,
Martinez R
,
Argouarch A
,
Wang C
,
Huang C
,
Sohn PDongmin
,
Bowles KR
et al.
. 2019.
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
.
Stem Cell Reports.
Gan L
,
Cookson MR
,
Petrucelli L
,
La Spada AR
. 2018.
Converging pathways in neurodegeneration, from genetics to mechanisms.
.
Nat Neurosci. 21(10):1300-1309.
Samelson AJ
,
Ariqat N
,
McKetney J
,
Rohanitazangi G
,
Bravo CParra
,
Goodness D
,
Tian R
,
Grosjean P
,
Abskharon R
,
Eisenberg D
et al.
. 2023.
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
.
bioRxiv.
Dräger NM
,
Sattler SM
,
Huang CTzu-Ling
,
Teter OM
,
Leng K
,
Hashemi SHadi
,
Hong J
,
Aviles G
,
Clelland CD
,
Zhan L
et al.
. 2022.
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
.
Nat Neurosci.
Möller T
,
Bard F
,
Bhattacharya A
,
Biber K
,
Campbell B
,
Dale E
,
Eder C
,
Gan L
,
Garden GA
,
Hughes ZA
et al.
. 2016.
Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
.
Glia. 64(10):1788-94.
Min S-W
,
Chen X
,
Tracy TE
,
Li Y
,
Zhou Y
,
Wang C
,
Shirakawa K
,
S Minami S
,
Defensor E
,
Mok SAnn
et al.
. 2015.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
.
Nat Med. 21(10):1154-62.
Cho S-H
,
Sun B
,
Zhou Y
,
Kauppinen TM
,
Halabisky B
,
Wes P
,
Ransohoff RM
,
Gan L
. 2011.
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
.
J Biol Chem. 286(37):32713-22.
Sun B
,
Zhou Y
,
Halabisky B
,
Lo I
,
Cho S-H
,
Mueller-Steiner S
,
Devidze N
,
Wang X
,
Grubb A
,
Gan L
. 2008.
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.
.
Neuron. 60(2):247-57.
D
Chen H
,
Fan L
,
Guo Q
,
Wong MYing
,
Yu F
,
Foxe N
,
Wang W
,
Nessim A
,
Carling G
,
Liu B
et al.
. 2023.
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
.
Res Sq.
Sayed FA
,
Telpoukhovskaia M
,
Kodama L
,
Li Y
,
Zhou Y
,
Le D
,
Hauduc A
,
Ludwig C
,
Gao F
,
Clelland C
et al.
. 2018.
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
.
Proc Natl Acad Sci U S A. 115(40):10172-10177.
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