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Found 17 results
Author
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Orr, Anna G
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2024
Zimmer TS
,
Orr AL
,
Orr AG
. 2024.
Astrocytes in selective vulnerability to neurodegenerative disease.
.
Trends Neurosci. 47(4):289-302.
Meadows SM
,
Palaguachi F
,
Jang MWendy
,
Licht-Murava A
,
Barnett D
,
Zimmer TS
,
Zhou C
,
McDonough SR
,
Orr AL
,
Orr AG
. 2024.
Hippocampal astrocytes induce sex-dimorphic effects on memory.
.
Cell Rep. 43(6):114278.
2023
Barnett D
,
Bohmbach K
,
Grelot V
,
Charlet A
,
Dallérac G
,
Ju YHa
,
Nagai J
,
Orr AG
. 2023.
Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting.
.
J Neurosci. 43(45):7463-7471.
Licht-Murava A
,
Meadows SM
,
Palaguachi F
,
Song SC
,
Jackvony S
,
Bram Y
,
Zhou C
,
Schwartz RE
,
Froemke RC
,
Orr AL
et al.
. 2023.
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
.
Sci Adv. 9(16):eade1282.
Garcia CP
,
Licht-Murava A
,
Orr AG
. 2023.
Effects of adenosine A2A receptors on cognitive function in health and disease.
.
Int Rev Neurobiol. 170:121-154.
2022
Xia D
,
Lianoglou S
,
Sandmann T
,
Calvert M
,
Suh JH
,
Thomsen E
,
Dugas J
,
Pizzo ME
,
DeVos SL
,
Earr TK
et al.
. 2022.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
.
Mol Neurodegener. 17(1):41.
2021
Murava ALicht
,
Meadows S
,
Palaguachi F
,
Song SC
,
Bram Y
,
Zhou C
,
Schwartz RE
,
Froemke RC
,
Orr AL
,
Orr AG
. 2021.
Dementia-linked TDP-43 dysregulation in astrocytes impairs memory, antiviral signaling, and chemokine-mediated astrocytic-neuronal interactions.
.
Alzheimers Dement. 17 Suppl 2:e058562.
2020
Acosta-Ruiz A
,
Gutzeit VA
,
Skelly MJane
,
Meadows S
,
Lee J
,
Parekh P
,
Orr AG
,
Liston C
,
Pleil KE
,
Broichhagen J
et al.
. 2020.
Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo.
.
Neuron. 105(3):446-463.e13.
2018
Orr AG
,
Lo I
,
Schumacher H
,
Ho K
,
Gill M
,
Guo W
,
Kim DH
,
Knox A
,
Saito T
,
Saido TC
et al.
. 2018.
Istradefylline reduces memory deficits in aging mice with amyloid pathology.
.
Neurobiol Dis. 110:29-36.
2015
Orr AG
,
Hsiao EC
,
Wang MM
,
Ho K
,
Kim DH
,
Wang X
,
Guo W
,
Kang J
,
Yu G-Q
,
Adame A
et al.
. 2015.
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
.
Nat Neurosci. 18(3):423-34.
2012
Sanchez PE
,
Zhu L
,
Verret L
,
Vossel KA
,
Orr AG
,
Cirrito JR
,
Devidze N
,
Ho K
,
Yu G-Q
,
Palop JJ
et al.
. 2012.
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.
.
Proc Natl Acad Sci U S A. 109(42):E2895-903.
2010
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
Orr AG
,
Sharma A
,
Binder NB
,
Miller AH
,
Pearce BD
. 2010.
Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection.
.
J Mol Neurosci. 41(1):89-96.
Mullasseril P
,
Hansen KB
,
Vance KM
,
Ogden KK
,
Yuan H
,
Kurtkaya NL
,
Santangelo R
,
Orr AG
,
Le P
,
Vellano KM
et al.
. 2010.
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.
.
Nat Commun. 1:90.
2009
Orr AG
,
Orr AL
,
Li X-J
,
Gross RE
,
Traynelis SF
. 2009.
Adenosine A(2A) receptor mediates microglial process retraction.
.
Nat Neurosci. 12(7):872-8.
Gyoneva S
,
Orr AG
,
Traynelis SF
. 2009.
Differential regulation of microglial motility by ATP/ADP and adenosine.
.
Parkinsonism Relat Disord. 15 Suppl 3:S195-9.
2008
Mannaioni G
,
Orr AG
,
Hamill CE
,
Yuan H
,
Pedone KH
,
McCoy KL
,
Palmini RBerlinguer
,
Junge CE
,
C Lee J
,
Yepes M
et al.
. 2008.
Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.
.
J Biol Chem. 283(29):20600-11.