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Found 17 results
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Holtzman, David M
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2
Wong MYing
,
Lewis M
,
Doherty JJ
,
Shi Y
,
Cashikar AG
,
Amelianchik A
,
Tymchuk S
,
Sullivan PM
,
Qian M
,
Covey DF
et al.
. 2020.
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
.
J Neuroinflammation. 17(1):192.
A
Carling GK
,
Fan L
,
Foxe NR
,
Norman K
,
Ye P
,
Wong MYing
,
Zhu D
,
Yu F
,
Xu J
,
Yarahmady A
et al.
. 2024.
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
.
bioRxiv.
Carling GK
,
Fan L
,
Foxe NR
,
Norman K
,
Wong MYing
,
Zhu D
,
Corona C
,
Razzoli A
,
Yu F
,
Yarahmady A
et al.
. 2024.
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
.
Neuron.
Brendza RP
,
Bacskai BJ
,
Cirrito JR
,
Simmons KA
,
Skoch JM
,
Klunk WE
,
Mathis CA
,
Bales KR
,
Paul SM
,
Hyman BT
et al.
. 2005.
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
.
J Clin Invest. 115(2):428-33.
DeMattos RB
,
Cirrito JR
,
Parsadanian M
,
May PC
,
O'dell MA
,
Taylor JW
,
Harmony JAK
,
Aronow BJ
,
Bales KR
,
Paul SM
et al.
. 2004.
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.
.
Neuron. 41(2):193-202.
Shi Y
,
Yamada K
,
Liddelow SAntony
,
Smith ST
,
Zhao L
,
Luo W
,
Tsai RM
,
Spina S
,
Grinberg LT
,
Rojas JC
et al.
. 2017.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
.
Nature. 549(7673):523-527.
B
DeMattos RB
,
Bales KR
,
Cummins DJ
,
Paul SM
,
Holtzman DM
. 2002.
Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.
.
Science. 295(5563):2264-7.
C
DeMattos RB
,
O'dell MA
,
Parsadanian M
,
Taylor JW
,
Harmony JAK
,
Bales KR
,
Paul SM
,
Aronow BJ
,
Holtzman DM
. 2002.
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 99(16):10843-8.
D
Wahrle SE
,
Jiang H
,
Parsadanian M
,
Hartman RE
,
Bales KR
,
Paul SM
,
Holtzman DM
. 2005.
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
.
J Biol Chem. 280(52):43236-42.
E
Hunter JM
,
Cirrito JR
,
Restivo JL
,
Kinley RD
,
Sullivan PM
,
Holtzman DM
,
Koger D
,
DeLong C
,
Lin S
,
Zhao L
et al.
. 2012.
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
.
Brain Res. 1467:120-32.
G
Bateman RJ
,
Siemers ER
,
Mawuenyega KG
,
Wen G
,
Browning KR
,
Sigurdson WC
,
Yarasheski KE
,
Friedrich SW
,
DeMattos RB
,
May PC
et al.
. 2009.
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.
.
Ann Neurol. 66(1):48-54.
H
Fagan AM
,
Watson M
,
Parsadanian M
,
Bales KR
,
Paul SM
,
Holtzman DM
. 2002.
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.
.
Neurobiol Dis. 9(3):305-18.
Castellano JM
,
Kim J
,
Stewart FR
,
Jiang H
,
DeMattos RB
,
Patterson BW
,
Fagan AM
,
Morris JC
,
Mawuenyega KG
,
Cruchaga C
et al.
. 2011.
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
.
Sci Transl Med. 3(89):89ra57.
I
Dodart J-C
,
Bales KR
,
Gannon KS
,
Greene SJ
,
DeMattos RB
,
Mathis C
,
DeLong CA
,
Wu S
,
Wu X
,
Holtzman DM
et al.
. 2002.
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
.
Nat Neurosci. 5(5):452-7.
Zhao L
,
Gottesdiener AJ
,
Parmar M
,
Li M
,
Kaminsky SM
,
Chiuchiolo MJ
,
Sondhi D
,
Sullivan PM
,
Holtzman DM
,
Crystal RG
et al.
. 2016.
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
.
Neurobiol Aging. 44:159-72.
O
Kim J
,
Castellano JM
,
Jiang H
,
Basak JM
,
Parsadanian M
,
Pham V
,
Mason SM
,
Paul SM
,
Holtzman DM
. 2009.
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
.
Neuron. 64(5):632-44.
S
Cirrito JR
,
Yamada KA
,
Finn MBeth
,
Sloviter RS
,
Bales KR
,
May PC
,
Schoepp DD
,
Paul SM
,
Mennerick S
,
Holtzman DM
. 2005.
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
.
Neuron. 48(6):913-22.