Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 21 results

Filters: Author is Luo, Wenjie [Clear All Filters]

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Bettayeb K, Chang JC, Luo W, Aryal S, Varotsis D, Randolph L, Netzer WJ, Greengard P, Flajolet M. 2016. δ-COP modulates Aβ peptide formation via retrograde trafficking of APP.. Proc Natl Acad Sci U S A. 113(19):5412-7.

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Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. 2016. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 92(1):252-264.

Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. 2016. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 90(4):724-39.

Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S. 2014. Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.. Mol Neurodegener. 9:52.

Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Huttenhain R, Kauwe G et al.. 2022. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.. Cell. 185(4):712-728.e14.

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Hardwick SA, Hu W, Joglekar A, Fan L, Collier PG, Foord C, Balacco J, Lanjewar S, Sampson MMcGuirk, Koopmans F et al.. 2022. Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue.. Nat Biotechnol.

Gupta I, Collier PG, Haase B, Mahfouz A, Joglekar A, Floyd T, Koopmans F, Barres B, Smit AB, Sloan SA et al.. 2018. Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells.. Nat Biotechnol.

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Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P et al.. 2007. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.. Proc Natl Acad Sci U S A. 104(22):9511-6.

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Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V et al.. 2020. A Pentacyclic Triterpene from Targets γ-Secretase.. ACS Chem Neurosci. 11(18):2827-2835.

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Du H, Wong MYing, Zhang T, Santos MNunez, Hsu C, Zhang J, Yu H, Luo W, Hu F. 2021. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.. Life Sci Alliance. 4(7)

Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al.. 2022. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.

Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul SM. 2015. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.. Sci Rep. 5:11161.

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Faraco G, Park L, Zhou P, Luo W, Paul SM, Anrather J, Iadecola C. 2016. Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP.. J Cereb Blood Flow Metab. 36(1):241-52.

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Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang L-L, Huang T, Luo W et al.. 2021. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.. J Exp Med. 218(8)

He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP et al.. 2010. Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.. Nature. 467(7311):95-8.

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Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al.. 2020. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.

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Naseri NN, Wang H, Guo J, Sharma M, Luo W. 2019. The complexity of tau in Alzheimer's disease.. Neurosci Lett. 705:183-194.

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Cao J, Gaamouch FEl, Meabon JS, Meeker KD, Zhu L, Zhong MB, Bendik J, Elder G, Jing P, Xia J et al.. 2017. ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.. Sci Rep. 7(1):11372.

Shi Y, Yamada K, Liddelow SAntony, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC et al.. 2017. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.. Nature. 549(7673):523-527.

Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MYing, Horowitz R et al.. 2021. AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.. Sci Transl Med. 13(622):eabe3947.

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Wong MYing, Lewis M, Doherty JJ, Shi Y, Cashikar AG, Amelianchik A, Tymchuk S, Sullivan PM, Qian M, Covey DF et al.. 2020. 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.. J Neuroinflammation. 17(1):192.