Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 424 results
[ Author(Desc)] Title Type Year
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Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu H-J, Izumi Y et al..  2013.  The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.. J Neurosci. 33(44):17290-300.
Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL.  2010.  How to improve R&D productivity: the pharmaceutical industry's grand challenge.. Nat Rev Drug Discov. 9(3):203-14.
Perevoshchikova IV, Quinlan CL, Orr AL, Gerencser AA, Brand MD.  2013.  Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.. Free Radic Biol Med. 61:298-309.
Petsko GA.  2013.  Open questions: Zombie projects, translational research, and the real secret of the inside of the cell.. BMC Biol. 11:97.
Pfau SJ, Langen UH, Fisher TM, Prakash I, Nagpurwala F, Lozoya RA, Lee W-CAllen, Wu Z, Gu C.  2024.  Characteristics of blood-brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells.. Nat Neurosci. 27(10):1892-1903.
Pham T-H, Qiu Y, Liu J, Zimmer S, O'Neill E, Xie L, Zhang P.  2022.  Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing.. Patterns (N Y). 3(4):100441.
Pineda A, Burré J.  2017.  Modulating membrane binding of α-synuclein as a therapeutic strategy.. Proc Natl Acad Sci U S A. 114(6):1223-1225.
Poleksic A, Xie L.  2019.  Database of adverse events associated with drugs and drug combinations.. Sci Rep. 9(1):20025.
Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ et al..  2012.  Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.. Neurosci Lett. 520(1):104-9.
Pranski E, Van Sanford CD, Dalal N, Orr AL, Karmali D, Cooper DS, Gearing M, Lah JJ, Levey AI, Betarbet R.  2013.  NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.. Neurosci Lett. 547:16-20.
Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS.  2012.  Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.. J Neuroinflammation. 9:67.
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Qiao Y, Giannopoulou EG, Chan CHin, Park S-H, Gong S, Chen J, Hu X, Elemento O, Ivashkiv LB.  2013.  Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.. Immunity. 39(3):454-69.
Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Orr AL, Brand MD.  2013.  Sites of reactive oxygen species generation by mitochondria oxidizing different substrates.. Redox Biol. 1:304-12.
Quinlan CL, Treberg JR, Perevoshchikova IV, Orr AL, Brand MD.  2012.  Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.. Free Radic Biol Med. 53(9):1807-17.
Quinlan CL, Orr AL, Perevoshchikova IV, Treberg JR, Ackrell BA, Brand MD.  2012.  Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions.. J Biol Chem. 287(32):27255-64.
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Ray SD, Parmar M, Syed I, Rathod J, Zinkovsky D, Bulku E, Gigliotti J, Hackman RM, Stohs SJ.  2008.  Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice.. Phytother Res. 22(4):458-71.
Reichlin A, Hu Y, Meffre E, Nagaoka H, Gong S, Kraus M, Rajewsky K, Nussenzweig MC.  2001.  B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta.. J Exp Med. 193(1):13-23.
Rho J, Gong S, Kim N, Choi Y.  2001.  TDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo.. Mol Cell Biol. 21(24):8365-70.
Ringe D, Petsko GA.  2009.  What are pharmacological chaperones and why are they interesting? J Biol. 8(9):80.
Rodriguez-Rodriguez P, Arroyo-Garcia LEnrique, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC et al..  2024.  A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons.. Brain. 147(7):2384-2399.
Rohan ML, Yamamoto RT, Ravichandran CT, Cayetano KR, Morales OG, Olson DP, Vitaliano G, Paul SM, Cohen BM.  2014.  Rapid mood-elevating effects of low field magnetic stimulation in depression.. Biol Psychiatry. 76(3):186-93.
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Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D et al..  2023.  CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. bioRxiv.
Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu G-Q, Palop JJ et al..  2012.  Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.. Proc Natl Acad Sci U S A. 109(42):E2895-903.
Sanchez-Mejia RO, Newman JW, Toh S, Yu G-Q, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L et al..  2008.  Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.. Nat Neurosci. 11(11):1311-8.
Sang T-K, Li C, Liu W, Rodriguez A, Abrams JM, S Zipursky L, Jackson GR.  2005.  Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.. Hum Mol Genet. 14(3):357-72.