Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 410 results
[ Author(Desc)] Title Type Year
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Sharma M, Burré J, Südhof TC.  2012.  Proteasome inhibition alleviates SNARE-dependent neurodegeneration.. Sci Transl Med. 4(147):147ra113.
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC.  2012.  CSPα knockout causes neurodegeneration by impairing SNAP-25 function.. EMBO J. 31(4):829-41.
Sharma M, Pampinella F, Nemes C, Benharouga M, So J, Du K, Bache KG, Papsin B, Zerangue N, Stenmark H et al..  2004.  Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.. J Cell Biol. 164(6):923-33.
Sharma M, Burré J, Südhof TC.  2011.  CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.. Nat Cell Biol. 13(1):30-9.
Shi Y, Yamada K, Liddelow SAntony, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC et al..  2017.  ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.. Nature. 549(7673):523-527.
Shim J-H, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA et al..  2013.  Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.. J Clin Invest. 123(9):4010-22.
Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al..  2021.  Reducing acetylated tau is neuroprotective in brain injury.. Cell.
Siemers ER, Friedrich S, Dean RA, Gonzales CR, Farlow MR, Paul SM, DeMattos RB.  2010.  Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.. Clin Neuropharmacol. 33(2):67-73.
Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JMM, Pybus B, Ringe D, Petsko GA, Boxer SG et al..  2013.  Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.. Proc Natl Acad Sci U S A. 110(28):E2552-61.
Singh SKumar, Kumar S, Viswakarma N, Principe DR, Das S, Sondarva G, Nair RSathish, Srivastava P, Sinha SC, Grippo PJ et al..  2021.  MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3.. Oncogene. 40(43):6153-6165.
Sinha S, Gan L, Pieper AA.  2025.  Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease.. Neurotherapeutics. 22(3):e00589.
Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT et al..  2018.  Military-related risk factors for dementia.. Alzheimers Dement. 14(12):1651-1662.
Sohn PDongmin, Huang CTzu-Ling, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok S-A, Freilich R et al..  2019.  Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.. Neuron.
Sohn PDongmin, Tracy TE, Son H-I, Zhou Y, Leite REP, Miller BL, Seeley WW, Grinberg LT, Gan L.  2016.  Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.. Mol Neurodegener. 11(1):47.
Sokhi UK, Liber MP, Frye L, Park S, Kang K, Pannellini T, Zhao B, Norinsky R, Ivashkiv LB, Gong S.  2018.  Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.. Nat Commun. 9(1):658.
Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M et al..  2019.  Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.. Nat Genet. 51(8):1252-1262.
Sparwasser T, Gong S, Li JYH, Eberl G.  2004.  General method for the modification of different BAC types and the rapid generation of BAC transgenic mice.. Genesis. 38(1):39-50.
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.. Mol Psychiatry. 18(8):889-97.
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G et al..  2013.  Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.. Mol Psychiatry. 18(8):882-8.
Strauss KA, Markx S, Georgi B, Paul SM, Jinks RN, Hoshi T, McDonald A, First MB, Liu W, Benkert AR et al..  2014.  A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.. Hum Mol Genet. 23(23):6395-406.
Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung Y-F, Yang Q et al..  2025.  Brain-wide neuronal circuit connectome of human glioblastoma.. Nature. 641(8061):222-231.
Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L.  2009.  Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.. Cell Stem Cell. 5(6):624-33.
Sun B, Zhou Y, Halabisky B, Lo I, Cho S-H, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L.  2008.  Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.. Neuron. 60(2):247-57.
Sun B, Gan L.  2011.  Manipulation of gene expression in the central nervous system with lentiviral vectors.. Methods Mol Biol. 670:155-68.
Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD.  2012.  Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury.. Mol Cell Biochem. 365(1-2):351-61.