Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 424 results

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Wallace CH, Oliveros G, Serrano PA, Rockwell P, Xie L, Figueiredo-Pereira M. 2022. Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer's model.. Life Sci Alliance. 5(12)

Wang LY, Gan L, Perney TM, Schwartz I, Kaczmarek LK. 1998. Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion.. Proc Natl Acad Sci U S A. 95(4):1882-7.

Wang S, Qi C, Rajpurohit C, Ghosh B, Xiong W, Wang B, Qi Y, Hwang SHee, Hammock BD, Li H et al.. 2025. Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model.. Mol Neurodegener. 20(1):44.

Wang C, Zhao C, Hu X, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burré J et al.. 2024. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.. bioRxiv.

Wang C-E, Tydlacka S, Orr AL, Yang S-H, Graham RK, Hayden MR, Li S, Chan AWS, Li X-J. 2008. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.. Hum Mol Genet. 17(17):2738-51.

Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PDongmin, Ludwig C, Meyer-Franke A et al.. 2017. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.. Stem Cell Reports. 9(4):1221-1233.

Wang C, Zhang K, Cai B, Haller JE, Carnazza KE, Hu J, Zhao C, Tian Z, Hu X, Hall D et al.. 2024. VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates.. Nat Cell Biol. 26(8):1287-1295.

Wang C, Zhao C, Xiao H, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burré J et al.. 2024. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.. Elife. 13

Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al.. 2022. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.

Wang LY, Gan L, Forsythe ID, Kaczmarek LK. 1998. Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones.. J Physiol. 509 ( Pt 1):183-94.

Wang C, Sun B, Zhou Y, Grubb A, Gan L. 2012. Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.. J Biol Chem. 287(47):39834-41.

Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L. 2018. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.. Curr Opin Neurobiol. 48:52-58.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LHerl, Seeley WW et al.. 2014. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.

Ward ME, Chen R, Huang H-Y, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P et al.. 2017. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.. Sci Transl Med. 9(385)

Wes PD, Sayed FA, Bard F, Gan L. 2016. Targeting microglia for the treatment of Alzheimer's Disease.. Glia. 64(10):1710-32.

A Willsey J, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA et al.. 2018. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.. Cell. 174(3):505-520.

Witten IB, Steinberg EE, Lee SYeun, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C et al.. 2011. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.. Neuron. 72(5):721-33.

Wong H-S, Monternier P-A, Orr AL, Brand MD. 2018. Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria.. Methods Mol Biol. 1782:287-299.

Wong MYing, Lewis M, Doherty JJ, Shi Y, Cashikar AG, Amelianchik A, Tymchuk S, Sullivan PM, Qian M, Covey DF et al.. 2020. 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.. J Neuroinflammation. 17(1):192.

Wu Y, Liu Q, Xie L. 2023. Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses.. Cell Rep Methods. 3(4):100452.

Wu Y, Liu Q, Qiu Y, Xie L. 2022. Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer's disease drug repurposing.. PLoS Comput Biol. 18(8):e1010367.

Wu X, Gong S, Roy-Burman P, Lee P, Culig Z. 2013. Current mouse and cell models in prostate cancer research.. Endocr Relat Cancer. 20(4):R155-70.

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Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al.. 2022. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.

Xiao L, Zhang C, Li X, Gong S, Hu R, Balasubramanian R, W WFCrowley, Hastings MH, Zhou Q-Y. 2014. Signaling role of prokineticin 2 on the estrous cycle of female mice.. PLoS One. 9(3):e90860.

Xie L, Xie L. 2023. Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.. PLoS Comput Biol. 19(8):e1010974.