Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 330 results
Author Title [ Type(Desc)] Year
Journal Article
Murava ALicht, Meadows S, Palaguachi F, Song SC, Bram Y, Zhou C, Schwartz RE, Froemke RC, Orr AL, Orr AG.  2021.  Dementia-linked TDP-43 dysregulation in astrocytes impairs memory, antiviral signaling, and chemokine-mediated astrocytic-neuronal interactions.. Alzheimers Dement. 17 Suppl 2:e058562.
Landon MR, Lieberman RL, Hoang QQ, Ju S, Caaveiro JMM, Orwig SD, Kozakov D, Brenke R, Chuang G-Y, Beglov D et al..  2009.  Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.. J Comput Aided Mol Des. 23(8):491-500.
Lechardeur D, Drzymala L, Sharma M, Zylka D, Kinach R, Pacia J, Hicks C, Usmani N, Rommens JM, Lukacs GL.  2000.  Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD).. J Cell Biol. 150(2):321-34.
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S.  2014.  Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.. Neuropharmacology. 85:232-42.
Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C et al..  2018.  Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.. Proc Natl Acad Sci U S A. 115(40):10172-10177.
Gyoneva S, Orr AG, Traynelis SF.  2009.  Differential regulation of microglial motility by ATP/ADP and adenosine.. Parkinsonism Relat Disord. 15 Suppl 3:S195-9.
Telpoukhovskaia MA, Liu K, Sayed FA, Etchegaray JIker, Xie M, Zhan L, Li Y, Zhou Y, Le D, Bahr BA et al..  2020.  Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.. Sci Rep. 10(1):13688.
Sokhi UK, Liber MP, Frye L, Park S, Kang K, Pannellini T, Zhao B, Norinsky R, Ivashkiv LB, Gong S.  2018.  Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.. Nat Commun. 9(1):658.
Kodama L, Gan L.  2019.  Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases? Trends Mol Med.
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LHerl, Seeley WW et al..  2014.  Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.
Lieberman RL, J D'Aquino A, Ringe D, Petsko GA.  2009.  Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.. Biochemistry. 48(22):4816-27.
Bodick NC, Offen WW, Levey AI, Cutler NR, Gauthier SG, Satlin A, Shannon HE, Tollefson GD, Rasmussen K, Bymaster FP et al..  1997.  Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.. Arch Neurol. 54(4):465-73.
Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK.  1995.  Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts.. J Neurophysiol. 74(1):207-17.
Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, DeLong C, Lin S, Zhao L et al..  2012.  Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.. Brain Res. 1467:120-32.
Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L.  2018.  Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.. Curr Opin Neurobiol. 48:52-58.
Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al..  2020.  The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.
Mukherjee K, Sharma M, Jahn R, Wahl MC, Südhof TC.  2010.  Evolution of CASK into a Mg2+-sensitive kinase.. Sci Signal. 3(119):ra33.
Heintz N, Gong S.  2019.  Examination of Bacterial Artificial Chromosome (BAC) DNA Quality and Quantity by Pulsed-Field Gel Electrophoresis.. Cold Spring Harb Protoc. 2019(11)
Chen X, Gan L.  2019.  An exercise-induced messenger boosts memory in Alzheimer's disease.. Nat Med. 25(1):20-21.
Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM.  1999.  Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.. J Clin Invest. 103(6):R15-R21.
Dong Q, Gentry NW, McMahon T, Yamazaki M, Benitez-Rivera L, Wang T, Gan L, Ptáček L, Fu Y-H.  2022.  Familial natural short sleep mutations reduce Alzheimer pathology in mice.. iScience. 25(4):103964.
Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK.  1998.  Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.. Nat Neurosci. 1(6):462-9.
Mastroberardino PG, Orr AL, Hu X, Na HMee, J Greenamyre T.  2008.  A FRET-based method to study protein thiol oxidation in histological preparations.. Free Radic Biol Med. 45(7):971-81.
Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, H Koerber R et al..  2011.  The functional organization of cutaneous low-threshold mechanosensory neurons.. Cell. 147(7):1615-27.
He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP et al..  2010.  Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.. Nature. 467(7311):95-8.