Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 410 results

Author Title [ Type

] Year

Journal Article

Meadows SM, Palaguachi F, Jang MWendy, Licht-Murava A, Barnett D, Zimmer TS, Zhou C, McDonough SR, Orr AL, Orr AG. 2024. Hippocampal astrocytes induce sex-dimorphic effects on memory.. Cell Rep. 43(6):114278.

Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL. 2010. How to improve R&D productivity: the pharmaceutical industry's grand challenge.. Nat Rev Drug Discov. 9(3):203-14.

Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM. 2002. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.. Neurobiol Dis. 9(3):305-18.

Bales KR, Liu F, Wu S, Lin S, Koger D, DeLong C, Hansen JC, Sullivan PM, Paul SM. 2009. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.. J Neurosci. 29(21):6771-9.

Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C et al.. 2011. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.. Sci Transl Med. 3(89):89ra57.

Bravo CParra, Giani AMaria, Perez JMadero, Zhao Z, Samelson A, Wong MYing, Evangelisti A, Fan L, Pozner T, Mercedes M et al.. 2023. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. bioRxiv.

Bravo CParra, Giani AMaria, Madero-Pérez J, Zhao Z, Wan Y, Samelson AJ, Wong MYing, Evangelisti A, Cordes E, Fan L et al.. 2024. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. Cell. 187(10):2446-2464.e22.

Faraco G, Park L, Zhou P, Luo W, Paul SM, Anrather J, Iadecola C. 2016. Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP.. J Cereb Blood Flow Metab. 36(1):241-52.

Burré J, Zimmermann H, Volknandt W. 2007. Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.. J Neurochem. 103(1):276-87.

Alarcón-Espósito J, Nagiri RKumar, Gan L, Sinha SC. 2025. Identification and development of cGAS inhibitors and their uses to treat Alzheimer's disease.. Neurotherapeutics. 22(3):e00536.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S et al.. 2004. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.. J Biol Chem. 279(7):5565-72.

Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. 2009. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.. Cell Stem Cell. 5(6):624-33.

Dodart J-C, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM et al.. 2002. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.. Nat Neurosci. 5(5):452-7.

Burré J, Zimmermann H, Volknandt W. 2007. Immunoisolation and subfractionation of synaptic vesicle proteins.. Anal Biochem. 362(2):172-81.

Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W. 2005. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.. J Neurochem. 95(6):1732-45.

Li X-J, Orr AL, Li S. 2010. Impaired mitochondrial trafficking in Huntington's disease.. Biochim Biophys Acta. 1802(1):62-5.

Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P et al.. 2010. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.. J Pharmacol Exp Ther. 333(3):650-62.

Sang T-K, Li C, Liu W, Rodriguez A, Abrams JM, S Zipursky L, Jackson GR. 2005. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.. Hum Mol Genet. 14(3):357-72.

Ward ME, Chen R, Huang H-Y, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P et al.. 2017. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.. Sci Transl Med. 9(385)

Boselli M, Lee B-H, Robert J, Prado MA, Min S-W, Cheng C, M Silva C, Seong C, Elsasser S, Hatle KM et al.. 2017. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.. J Biol Chem. 292(47):19209-19225.

Orr AL, Ashok D, Sarantos MR, Shi T, Hughes RE, Brand MD. 2013. Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.. Free Radic Biol Med. 65:1047-1059.

Orr AG, Sharma A, Binder NB, Miller AH, Pearce BD. 2010. Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection.. J Mol Neurosci. 41(1):89-96.

Esposito L, Gan L, Yu G-Q, Essrich C, Mucke L. 2004. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.. J Neurochem. 91(6):1260-74.

Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG et al.. 2016. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.. Neurobiol Aging. 44:159-72.

Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC et al.. 2018. Istradefylline reduces memory deficits in aging mice with amyloid pathology.. Neurobiol Dis. 110:29-36.