Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 424 results
Author [ Title(Asc)] Type Year
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Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al..  2024.  Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.. Nat Commun. 15(1):10269.
Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW.  2019.  Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.. J Alzheimers Dis. 68(3):991-1011.
Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR et al..  2024.  Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.. PNAS Nexus. 3(5):pgae179.
Bales KR, Du Y, Holtzman D, Cordell B, Paul SM.  2000.  Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E.. Neurobiol Aging. 21(3):427-32;discussion451-3.
Zhou C, Hardin EJ, Zimmer TS, Jackvony S, Barnett D, Khobrekar N, Giacomelli E, Studer L, Orr AL, Orr AG.  2025.  Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology.. Neurobiol Dis. 211:106939.
Paul SM, Purdy RH.  1992.  Neuroactive steroids.. FASEB J. 6(6):2311-22.
Ford BD, Liu Y, Mann MAnne, Krauss R, Phillips K, Gan L, Fischbach GD.  2003.  Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes.. Biochem Biophys Res Commun. 308(1):23-8.
Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L et al..  2018.  Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.. Neuron. 98(1):75-89.e5.
Diao J, Burré J, Vivona S, Cipriano DJ, Sharma M, Kyoung M, Südhof TC, Brunger AT.  2013.  Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.. Elife. 2:e00592.
Quinlan CL, Treberg JR, Perevoshchikova IV, Orr AL, Brand MD.  2012.  Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.. Free Radic Biol Med. 53(9):1807-17.
Zhu PK, W Zheng S, Zhang P, Jing M, Borden PM, Ali F, Guo K, Feng J, Marvin JS, Wang Y et al..  2020.  Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.. Nano Lett. 20(6):4073-4083.
Wang C, Zhao C, Hu X, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burré J et al..  2024.  N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.. bioRxiv.
Wang C, Zhao C, Xiao H, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burré J et al..  2024.  N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.. Elife. 13
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Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, Cookson MR.  2005.  Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.. Proc Natl Acad Sci U S A. 102(16):5703-8.
Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S et al..  2009.  Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.. Nat Neurosci. 12(7):826-8.
Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al..  2022.  Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.
Mattos C, Bellamacina CR, Peisach E, Pereira A, Vitkup D, Petsko GA, Ringe D.  2006.  Multiple solvent crystal structures: probing binding sites, plasticity and hydration.. J Mol Biol. 357(5):1471-82.
Du H, Wong MYing, Zhang T, Santos MNunez, Hsu C, Zhang J, Yu H, Luo W, Hu F.  2021.  A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.. Life Sci Alliance. 4(7)
Guo M, Gong S, Maric S, Misulovin Z, Pack M, Mahnke K, Nussenzweig MC, Steinman RM.  2000.  A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells.. Hum Immunol. 61(8):729-38.
Pineda A, Burré J.  2017.  Modulating membrane binding of α-synuclein as a therapeutic strategy.. Proc Natl Acad Sci U S A. 114(6):1223-1225.
Yang Z, Jiang H, Chaichanasakul T, Chachainasakul T, Gong S, Yang XWilliam, Heintz N, Lin S.  2006.  Modified bacterial artificial chromosomes for zebrafish transgenesis.. Methods. 39(3):183-8.
Gong S, X Yang W.  2005.  Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice.. Curr Protoc Neurosci. Chapter 5:Unit5.21.
Viswakarma N, Sondarva G, Principe DR, Nair RSathish, Kumar S, Singh SKumar, Das S, Sinha SC, Grippo PJ, Grimaldo S et al..  2021.  Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.. Cancer Lett. 515:1-13.
Kumar S, Singh SKumar, Viswakarma N, Sondarva G, Nair RSathish, Sethupathi P, Sinha SC, Emmadi R, Hoskins K, Danciu O et al..  2020.  Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.. Proc Natl Acad Sci U S A. 117(14):7961-7970.
Bose A, M Beal F.  2016.  Mitochondrial dysfunction in Parkinson's disease.. J Neurochem.