News and Events | Page 3 | Helen & Robert Appel Alzheimer’s Disease Research Institute

Dr. Jacqueline Burre Appointed Co-Director of Neuroscience Graduate Program

The Appel Institute is thrilled to announce the appointment of Dr. Jacqueline Burre as a Co-Director of the Neuroscience Graduate Program. We wish her great success in this exciting new role.

New Publication

The Gan lab has published a new study in Neuron, where Carling et al. investigate the mechanistic underpinnings of the strongest Alzheimer's Disease risk factors: APOE4 and TREM2-R47H. Carling et al. find that the combination of APOE4 and TREM2-R47H risk factors in mice harboring the P301S tau mutation amplifies microglial cGAS-STING signaling and related senescence, specifically in female mice. This work highlights cGAS-STING and senescence pathways as potential...

Dr. Constance Zhou, an MD-PhD student in the Orr lab, successfully defended their dissertation!

Dr. Zhou’s research focused on astrocytic nucleocytoplasmic changes and stress granules associated with TDP-43 pathology and neuroimmune signaling. Thank you to the thesis committee, Drs. Li Gan (Appel Institutes, WCM), Lorenz Studer (Sloan Kettering), and Michael Rout (Rockefeller University), for their great insights and support for the project. We wish Connie all the best in their continued clinical training and future endeavors in medicine!

Congratulations to Minwoo

Postdoctoral fellow Minwoo Wendy Jang was selected for a postdoctoral fellowship from the National Research Foundation of Korea, “Elucidating the Roles of Astrocytes in Sex-specific Responses to Social Isolation”.

New Publication

In the latest study from the Gan Lab, published in Molecular Neurodegeneration, Parra Bravo, Krukowski, and Barker et al. report two newly-generated anti-acetylated-tau-K174 antibodies that effectively mitigate neurobehavioral impairments and reduce pathology in PS19 mice— alone and in conjunction with traumatic brain injury (TBI).

The collaborative study was led by Celeste Parra Bravo from the Gan laboratory, Dr. Karen Krukowski from Dr. Susanna...