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Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

A new study by the Orr lab, published in Science Advances, reveals that dementia-linked buildup of TDP-43 protein within astrocytes disrupts antiviral pathways and impairs aspects of cognitive function.

In collaboration with the Schwartz lab at Weill Cornell Medicine and the Froemke lab at New York University, the authors report that people with Alzheimer’s disease (AD) or frontotemporal dementia (FTD) had aberrant accumulation of TDP...


The Orr lab celebrates its first graduate student doctoral dissertation!

The Appel Institute community warmly congratulates Dr. Samantha Meadows-Ortiz on her successful dissertation defense!

Dr. Meadows-Ortiz’s research “Astrocytes Regulate Spatial Memory in a Sex-Specific Manner” was completed in Dr. Anna Orr’s laboratory. Dr. Anjali Rajadhyaksha, Chairperson, Dr. Olga Boudker, and Dr. Kristen Pleil served as members of her examining committee in addition to Dr. Orr. She is the first of many graduate students to come to complete their doctoral degree in Dr...

Faculty photo

Welcome Dr. Zhuhao Wu to Appel!

After extensive national searches since 2020 and reviews of hundreds of candidates, Appel Institute successfully recruited Dr. Zhuhao Wu, a highly accomplished neuroscientist. He and his team expand Appel Institute’s imaging capabilities of mouse and human brains to accelerate Alzheimer's disease therapies from bench to bedside.

Dr. Wu received his PhD in Neuroscience at Johns Hopkins University, working on how our brains are properly built to sense the environment using Drosophila...

Weill Cornell Medicine Helen & Robert Appel Alzheimer’s Disease Research Institute 413 E. 69th St. New York, NY 10021