News and Events | Page 9 | Helen & Robert Appel Alzheimer’s Disease Research Institute

Burré lab enjoys double dose of graduate student doctoral dissertations!

The Appel Institute congratulates Drs. Noah Guiberson and Kathryn E. Carnazza on their dissertation defenses!

Dr. Guiberson's research focused on molecular mechanisms and strategies for STXBP1/Munc18-1 encephalopathies, conducted under Dr. Jaqueline Burré's guidance. His committee included Drs. Jeremy Dittman (Chair), David Eliezar, and Manu Sharma.

Dr. Carnazza's research examined membrane binding of synucleins in...

eft to right: Stephanie Jackvony (Anna Orr Lab), Lauren Komer (Jacqueline Burré Lab) and Gillian Carling (Li Gan Lab)

Congratulations! Graduate Students at Appel Institute are Awarded F31 Fellowships!

Graduate students within the Appel Institute, Stephanie Jackvony, Lauren Komer, and Gillian Carling have been awarded F31 predoctoral fellowships from the NIH. Stephanie Jackvony's research focuses on TDP-43 pathology effects on innate antiviral mechanisms in neurodegenerative disease. Lauren Komer is studying beta-synuclein's role in synaptic vesicle release. Gillian Carling's work examines the Trem2-APOE pathway in Alzheimer's Disease, specifically R47H effects on APOE3 and APOE4 in...

Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models

Congratulations to the Sharma lab for their recent work on alpha-synuclein pathogenesis recently published in Nature Communications!

In collaboration with the Burré lab, also at the Appel Institute, the team led by Dr. Manu Sharma found that pathogenic alpha-synuclein species accumulate within neuronal lysosomes and are released through SNARE-dependent lysosomal exocytosis, providing a novel mechanism by which pathogenic alpha-synuclein transmit from neuron-to-neuron and spread...

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

A collaborative effort between the Gan lab at the Appel Institute and the Kampmann lab at UCSF reveals regulators of disease states in a recent publication out now in Nature Neuroscience. The authors devised a fast and efficient method to generate induced microglia from iPSCs and developed CRISPRi/a platforms that can systematically discover regulators of microglia states and allow researchers to determine their function and therapeutic value. See the press release from WCM Newsroom...

Synaptic vesicle binding highlights interactions between synucleins are important to brain health

A collaboration between the Burré and Sharma labs, “Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins,” has recently been published in Cell Reports. Their work furthers our understanding of the composition of synuclein heteromultimers on the synaptic vesicle surface and shows that these synuclein heteromultimers govern the amount of physiologically active α-synuclein on synaptic vesicles. These findings highlight the need for a balance of synucleins for...