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H
Paul SM
,
Mytelka DS
,
Dunwiddie CT
,
Persinger CC
,
Munos BH
,
Lindborg SR
,
Schacht AL
. 2010.
How to improve R&D productivity: the pharmaceutical industry's grand challenge.
.
Nat Rev Drug Discov. 9(3):203-14.
Bales KR
,
Liu F
,
Wu S
,
Lin S
,
Koger D
,
DeLong C
,
Hansen JC
,
Sullivan PM
,
Paul SM
. 2009.
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
.
J Neurosci. 29(21):6771-9.
Castellano JM
,
Kim J
,
Stewart FR
,
Jiang H
,
DeMattos RB
,
Patterson BW
,
Fagan AM
,
Morris JC
,
Mawuenyega KG
,
Cruchaga C
et al.
. 2011.
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
.
Sci Transl Med. 3(89):89ra57.
Bravo CParra
,
Giani AMaria
,
Madero-Pérez J
,
Zhao Z
,
Wan Y
,
Samelson AJ
,
Wong MYing
,
Evangelisti A
,
Cordes E
,
Fan L
et al.
. 2024.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
.
Cell. 187(10):2446-2464.e22.
Bravo CParra
,
Giani AMaria
,
Madero-Pérez J
,
Zhao Z
,
Wan Y
,
Samelson AJ
,
Wong MYing
,
Evangelisti A
,
Cordes E
,
Fan L
et al.
. 2024.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
.
Cell. 187(10):2446-2464.e22.
I
Dodart J-C
,
Bales KR
,
Gannon KS
,
Greene SJ
,
DeMattos RB
,
Mathis C
,
DeLong CA
,
Wu S
,
Wu X
,
Holtzman DM
et al.
. 2002.
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
.
Nat Neurosci. 5(5):452-7.
Dodart J-C
,
Bales KR
,
Gannon KS
,
Greene SJ
,
DeMattos RB
,
Mathis C
,
DeLong CA
,
Wu S
,
Wu X
,
Holtzman DM
et al.
. 2002.
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
.
Nat Neurosci. 5(5):452-7.
Dodart J-C
,
Bales KR
,
Gannon KS
,
Greene SJ
,
DeMattos RB
,
Mathis C
,
DeLong CA
,
Wu S
,
Wu X
,
Holtzman DM
et al.
. 2002.
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
.
Nat Neurosci. 5(5):452-7.
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
L
Bales KR
,
Verina T
,
Dodel RC
,
Du Y
,
Altstiel L
,
Bender M
,
Hyslop P
,
Johnstone EM
,
Little SP
,
Cummins DJ
et al.
. 1997.
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
.
Nat Genet. 17(3):263-4.
Bales KR
,
Verina T
,
Dodel RC
,
Du Y
,
Altstiel L
,
Bender M
,
Hyslop P
,
Johnstone EM
,
Little SP
,
Cummins DJ
et al.
. 1997.
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
.
Nat Genet. 17(3):263-4.
Steele JW
,
Lachenmayer ML
,
Ju S
,
Stock A
,
Liken J
,
Kim SH
,
Delgado LM
,
Alfaro IE
,
Bernales S
,
Verdile G
et al.
. 2013.
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.
.
Mol Psychiatry. 18(8):889-97.
Steele JW
,
Lachenmayer ML
,
Ju S
,
Stock A
,
Liken J
,
Kim SH
,
Delgado LM
,
Alfaro IE
,
Bernales S
,
Verdile G
et al.
. 2013.
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.
.
Mol Psychiatry. 18(8):889-97.
Steele JW
,
Ju S
,
Lachenmayer ML
,
Liken J
,
Stock A
,
Kim SH
,
Delgado LM
,
Alfaro IE
,
Bernales S
,
Verdile G
et al.
. 2013.
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.
.
Mol Psychiatry. 18(8):882-8.
Steele JW
,
Ju S
,
Lachenmayer ML
,
Liken J
,
Stock A
,
Kim SH
,
Delgado LM
,
Alfaro IE
,
Bernales S
,
Verdile G
et al.
. 2013.
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.
.
Mol Psychiatry. 18(8):882-8.
Sanchez PE
,
Zhu L
,
Verret L
,
Vossel KA
,
Orr AG
,
Cirrito JR
,
Devidze N
,
Ho K
,
Yu G-Q
,
Palop JJ
et al.
. 2012.
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.
.
Proc Natl Acad Sci U S A. 109(42):E2895-903.
Liang Y
,
Lin S
,
Beyer TP
,
Zhang Y
,
Wu X
,
Bales KR
,
DeMattos RB
,
May PC
,
Li SDan
,
Jiang X-C
et al.
. 2004.
A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.
.
J Neurochem. 88(3):623-34.
Orr AL
,
Rutaganira FU
,
de Roulet D
,
Huang EJ
,
Hertz NT
,
Shokat KM
,
Nakamura K
. 2017.
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
.
Neurochem Int. 109:106-116.
M
Zhao L
,
Lin S
,
Bales KR
,
Gelfanova V
,
Koger D
,
DeLong C
,
Hale J
,
Liu F
,
Hunter JM
,
Paul SM
. 2009.
Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.
.
J Neurosci. 29(11):3603-12.
Paul SM
,
Doherty JJ
,
Robichaud AJ
,
Belfort GM
,
Chow BY
,
Hammond RS
,
Crawford DC
,
Linsenbardt AJ
,
Shu H-J
,
Izumi Y
et al.
. 2013.
The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.
.
J Neurosci. 33(44):17290-300.
Singh SKumar
,
Kumar S
,
Viswakarma N
,
Principe DR
,
Das S
,
Sondarva G
,
Nair RSathish
,
Srivastava P
,
Sinha SC
,
Grippo PJ
et al.
. 2021.
MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3.
.
Oncogene. 40(43):6153-6165.
Song M
,
Yang X
,
Ren X
,
Maliskova L
,
Li B
,
Jones IR
,
Wang C
,
Jacob F
,
Wu K
,
Traglia M
et al.
. 2019.
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
.
Nat Genet. 51(8):1252-1262.
Guiberson NGuy Lewis
,
Pineda A
,
Abramov D
,
Kharel P
,
Carnazza KE
,
Wragg RT
,
Dittman JS
,
Burré J
. 2018.
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones.
.
Nat Commun. 9(1):3986.
Krabbe G
,
S Minami S
,
Etchegaray JI
,
Taneja P
,
Djukic B
,
Davalos D
,
Le D
,
Lo I
,
Zhan L
,
Reichert MC
et al.
. 2017.
Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
.
Proc Natl Acad Sci U S A. 114(19):5029-5034.
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