Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 28 results
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2023
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERuth S, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G et al..  2023.  Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.. Nat Neurosci. 26(5):737-750.
Evering TH, Marston JL, Gan L, Nixon DF.  2023.  Transposable elements and Alzheimer's disease pathogenesis.. Trends Neurosci. 46(3):170-172.
2022
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Huttenhain R, Kauwe G et al..  2022.  Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.. Cell. 185(4):712-728.e14.
Wallace CH, Oliveros G, Serrano PA, Rockwell P, Xie L, Figueiredo-Pereira M.  2022.  Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer's model.. Life Sci Alliance. 5(12)
2020
Abramov D, Guiberson NGuy Lewis, Daab A, Na Y, Petsko GA, Sharma M, Burré J.  2020.  Targeted stabilization of Munc18-1 function via pharmacological chaperones.. EMBO Mol Med. :e12354.
Heintz N, Gong S.  2020.  Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Cloning of the A and B Homology Arms into the Shuttle Vector.. Cold Spring Harb Protoc. 2020(4):098053.
Heintz N, Gong S.  2020.  Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Electroporation of Competent BAC Host Cells with the Recombinant Shuttle Vector.. Cold Spring Harb Protoc. 2020(4):098079.
Heintz N, Gong S.  2020.  Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Preparation and Verification of the Recombinant Shuttle Vector.. Cold Spring Harb Protoc. 2020(4):098061.
Heintz N, Gong S.  2020.  Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Preparation of Shuttle Vector DNA.. Cold Spring Harb Protoc. 2020(4):098038.
Heintz N, Gong S.  2020.  Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Preparation of the A Homology Arm (A-Box) and B Homology Arm (B-Box).. Cold Spring Harb Protoc. 2020(4):098046.
Heintz N, Gong S.  2020.  Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Verification of Co-Integrates and Selection of Resolved BAC Clones.. Cold Spring Harb Protoc. 2020(4):098087.
2019
de Haas R, Heltzel LCMW, Tax D, van den Broek P, Steenbreker H, Verheij MMM, Russel FGM, Orr AL, Nakamura K, Smeitink JAM.  2019.  To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease.. Brain Commun. 1(1):fcz016.
2018
Tracy TE, Gan L.  2018.  Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.. Curr Opin Neurobiol. 51:134-138.
Fernandopulle MS, Prestil R, Grunseich C, Wang C, Gan L, Ward ME.  2018.  Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.. Curr Protoc Cell Biol. 79(1):e51.
Udeochu J, Sayed FA, Gan L.  2018.  TREM2 and Amyloid Beta: A Love-Hate Relationship.. Neuron. 97(5):991-993.
2016
Wes PD, Sayed FA, Bard F, Gan L.  2016.  Targeting microglia for the treatment of Alzheimer's Disease.. Glia. 64(10):1710-32.
Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  2016.  TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 92(1):252-264.
Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  2016.  TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 90(4):724-39.
2015
Kim KHye, Liu J, Galvin RJSells, Dage JL, Egeland JA, Smith RC, Merchant KM, Paul SM.  2015.  Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree.. PLoS One. 10(11):e0142693.
2014
Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S.  2014.  Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.. Mol Neurodegener. 9:52.
2012
Pappas DJ, Gabatto PA, Oksenberg D, Khankhanian P, Baranzini SE, Gan L, Oksenberg JR.  2012.  Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules.. Neuroscience. 226:10-20.
2011
Paul SM.  2011.  Therapeutic antibodies for brain disorders.. Sci Transl Med. 3(84):84ps20.
2008
Heiman M, Schaefer A, Gong S, Peterson JD, Day M, Ramsey KE, Suárez-Fariñas M, Schwarz C, Stephan DA, D Surmeier J et al..  2008.  A translational profiling approach for the molecular characterization of CNS cell types.. Cell. 135(4):738-48.
2007
Gong S, Doughty M, Harbaugh CR, Cummins A, Hatten ME, Heintz N, Gerfen CR.  2007.  Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs.. J Neurosci. 27(37):9817-23.
Gan L.  2007.  Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.. Drug News Perspect. 20(4):233-9.