Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 362 results

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2007

Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P et al.. 2007. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.. Proc Natl Acad Sci U S A. 104(22):9511-6.

Gong S, Doughty M, Harbaugh CR, Cummins A, Hatten ME, Heintz N, Gerfen CR. 2007. Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs.. J Neurosci. 27(37):9817-23.

Gong S, Doughty M, Harbaugh CR, Cummins A, Hatten ME, Heintz N, Gerfen CR. 2007. Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs.. J Neurosci. 27(37):9817-23.

Gan L. 2007. Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.. Drug News Perspect. 20(4):233-9.

2006

Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L et al.. 2006. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.. Neuron. 51(6):703-14.

Yang Z, Jiang H, Chaichanasakul T, Chachainasakul T, Gong S, Yang XWilliam, Heintz N, Lin S. 2006. Modified bacterial artificial chromosomes for zebrafish transgenesis.. Methods. 39(3):183-8.

2005

Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF. 2005. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.. J Neurosci. 25(17):4319-29.

Dodart J-C, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM, Paul SM. 2005. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 102(4):1211-6.

Gong S, X Yang W. 2005. Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice.. Curr Protoc Neurosci. Chapter 5:Unit5.21.

Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CAF, Breiderhoff T, Jansen P, Wu X et al.. 2005. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.. Proc Natl Acad Sci U S A. 102(38):13461-6.

Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CAF, Breiderhoff T, Jansen P, Wu X et al.. 2005. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.. Proc Natl Acad Sci U S A. 102(38):13461-6.

X Yang W, Gong S. 2005. An overview on the generation of BAC transgenic mice for neuroscience research.. Curr Protoc Neurosci. Chapter 5:Unit5.20.

Gu X, Li C, Wei W, Lo V, Gong S, Li S-H, Iwasato T, Itohara S, Li X-J, Mody I et al.. 2005. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.. Neuron. 46(3):433-44.

Gu X, Li C, Wei W, Lo V, Gong S, Li S-H, Iwasato T, Itohara S, Li X-J, Mody I et al.. 2005. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.. Neuron. 46(3):433-44.

Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CAA, Whim MD, Yang B. 2005. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.. Hear Res. 206(1-2):133-45.

Chen J, Zhou Y, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, Gan L. 2005. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.. J Biol Chem. 280(48):40364-74.

Hamill CE, Goldshmidt A, Nicole O, McKeon RJ, Brat DJ, Traynelis SF. 2005. Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery.. Clin Neurosurg. 52:29-44.

2004

Sparwasser T, Gong S, Li JYH, Eberl G. 2004. General method for the modification of different BAC types and the rapid generation of BAC transgenic mice.. Genesis. 38(1):39-50.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S et al.. 2004. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.. J Biol Chem. 279(7):5565-72.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S et al.. 2004. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.. J Biol Chem. 279(7):5565-72.

Esposito L, Gan L, Yu G-Q, Essrich C, Mucke L. 2004. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.. J Neurochem. 91(6):1260-74.

Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al.. 2004. New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.

Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al.. 2004. New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.

2003

Ford BD, Liu Y, Mann MAnne, Krauss R, Phillips K, Gan L, Fischbach GD. 2003. Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes.. Biochem Biophys Res Commun. 308(1):23-8.

Zhou Y, Su Y, Li B, Liu F, Ryder JW, Wu X, Gonzalez-DeWhitt PA, Gelfanova V, Hale JE, May PC et al.. 2003. Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.. Science. 302(5648):1215-7.