Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 397 results

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Gan L, Cookson MR, Petrucelli L, La Spada AR. 2018. Converging pathways in neurodegeneration, from genetics to mechanisms.. Nat Neurosci. 21(10):1300-1309.

Kember RL, Georgi B, Bailey-Wilson JE, Stambolian D, Paul SM, Bućan M. 2015. Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder.. BMC Genet. 16:27.

Gong S, Sanchez M, Nussenzweig MC. 1996. Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta.. J Exp Med. 184(6):2079-84.

Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D et al.. 2023. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. bioRxiv.

Dräger NM, Sattler SM, Huang CTzu-Ling, Teter OM, Leng K, Hashemi SHadi, Hong J, Aviles G, Clelland CD, Zhan L et al.. 2022. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.. Nat Neurosci.

Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA et al.. 2016. Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.. Glia. 64(10):1788-94.

Min S-W, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, S Minami S, Defensor E, Mok SAnn et al.. 2015. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.. Nat Med. 21(10):1154-62.

Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC et al.. 2013. Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.. Proc Natl Acad Sci U S A. 110(44):17820-5.

Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC. 2012. CSPα knockout causes neurodegeneration by impairing SNAP-25 function.. EMBO J. 31(4):829-41.

Sharma M, Burré J, Südhof TC. 2011. CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.. Nat Cell Biol. 13(1):30-9.

Buchholz S, Bell-Simons M, Cakmak C, Klimek J, Gan L, Zempel H. 2024. Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau.. Methods Mol Biol. 2754:533-549.

Wu X, Gong S, Roy-Burman P, Lee P, Culig Z. 2013. Current mouse and cell models in prostate cancer research.. Endocr Relat Cancer. 20(4):R155-70.

Cho S-H, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L. 2011. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.. J Biol Chem. 286(37):32713-22.

Sun B, Zhou Y, Halabisky B, Lo I, Cho S-H, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. 2008. Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.. Neuron. 60(2):247-57.

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Chen H, Fan L, Guo Q, Wong MYing, Yu F, Foxe N, Wang W, Nessim A, Carling G, Liu B et al.. 2023. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.. Res Sq.

Poleksic A, Xie L. 2019. Database of adverse events associated with drugs and drug combinations.. Sci Rep. 9(1):20025.

Kronin V, Wu L, Gong S, Nussenzweig MC, Shortman K. 2000. DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses.. Int Immunol. 12(5):731-5.

Wu Y, Liu Q, Qiu Y, Xie L. 2022. Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer's disease drug repurposing.. PLoS Comput Biol. 18(8):e1010367.

Cai T, Abbu KAlyssa, Liu Y, Xie L. 2022. DeepREAL: a deep learning powered multi-scale modeling framework for predicting out-of-distribution ligand-induced GPCR activity.. Bioinformatics. 38(9):2561-2570.

Head K, Gong S, Joseph S, Wang C, Burkhardt T, Rossi MR, LaDuca J, Matsui S-I, Vaughan M, Hicks DG et al.. 2007. Defining the expression pattern of the LGI1 gene in BAC transgenic mice.. Mamm Genome. 18(5):328-37.

Burré J, Sharma M, Südhof TC. 2015. Definition of a molecular pathway mediating α-synuclein neurotoxicity.. J Neurosci. 35(13):5221-32.

Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM. 2005. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.. J Biol Chem. 280(52):43236-42.

Du K, Sharma M, Lukacs GL. 2005. The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.. Nat Struct Mol Biol. 12(1):17-25.

Murava ALicht, Meadows S, Palaguachi F, Song SC, Bram Y, Zhou C, Schwartz RE, Froemke RC, Orr AL, Orr AG. 2021. Dementia-linked TDP-43 dysregulation in astrocytes impairs memory, antiviral signaling, and chemokine-mediated astrocytic-neuronal interactions.. Alzheimers Dement. 17 Suppl 2:e058562.

Landon MR, Lieberman RL, Hoang QQ, Ju S, Caaveiro JMM, Orwig SD, Kozakov D, Brenke R, Chuang G-Y, Beglov D et al.. 2009. Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.. J Comput Aided Mol Des. 23(8):491-500.