Skip to main content
Enter the terms you wish to search for.
Select Search Option
This Site
All WCM Sites
Directory
Menu
Weill Cornell Medicine
Care
Discover
Teach
Helen & Robert Appel Alzheimer’s Disease Research Institute
Explore this Website
Home
About Us
Toggle About Us menu options
About Alzheimer's
Open Positions
Staff Directory
Appel Postdoc Initiative (API)
Faculty
Toggle Faculty menu options
Gan Laboratory
Orr Laboratory
Burré Laboratory
Sharma Laboratory
Sinha Laboratory
Wu Laboratory
News & Events
Toggle News & Events menu options
Events
News
Giving
Contact Us
Weill Cornell Medicine
Care
Discover
Teach
Home
About Us
Faculty
News & Events
Giving
Contact Us
Home
Publications
Publications
Found 20 results
Author
[
Title
]
Type
Year
Filters:
Author
is
Xie, Lei
[Clear All Filters]
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
A
Sayed FA
,
Kodama L
,
Fan L
,
Carling GK
,
Udeochu JC
,
Le D
,
Li Q
,
Zhou L
,
Wong MYing
,
Horowitz R
et al.
. 2021.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
.
Sci Transl Med. 13(622):eabe3947.
B
Ayed M
,
Lim H
,
Xie L
. 2019.
Biological representation of chemicals using latent target interaction profile.
.
BMC Bioinformatics. 20(Suppl 24):674.
C
Pham T-H
,
Qiu Y
,
Liu J
,
Zimmer S
,
O'Neill E
,
Xie L
,
Zhang P
. 2022.
Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing.
.
Patterns (N Y). 3(4):100441.
D
Poleksic A
,
Xie L
. 2019.
Database of adverse events associated with drugs and drug combinations.
.
Sci Rep. 9(1):20025.
Wu Y
,
Liu Q
,
Qiu Y
,
Xie L
. 2022.
Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer's disease drug repurposing.
.
PLoS Comput Biol. 18(8):e1010367.
Cai T
,
Abbu KAlyssa
,
Liu Y
,
Xie L
. 2022.
DeepREAL: a deep learning powered multi-scale modeling framework for predicting out-of-distribution ligand-induced GPCR activity.
.
Bioinformatics. 38(9):2561-2570.
E
Xie L
,
Xie L
. 2023.
Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.
.
PLoS Comput Biol. 19(8):e1010974.
Cai T
,
Xie L
,
Zhang S
,
Chen M
,
He D
,
Badkul A
,
Liu Y
,
Namballa HKrishna
,
Dorogan M
,
Harding WW
et al.
. 2023.
End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins.
.
PLoS Comput Biol. 19(1):e1010851.
Liu Y
,
Lim H
,
Xie L
. 2022.
Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding.
.
BMC Bioinformatics. 23(Suppl 3):158.
F
Chaudry O
,
Ndukwe K
,
Xie L
,
Figueiredo-Pereira M
,
Serrano P
,
Rockwell P
. 2022.
Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats.
.
Sci Rep. 12(1):19129.
H
Wu Y
,
Liu Q
,
Xie L
. 2023.
Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses.
.
Cell Rep Methods. 3(4):100452.
P
Xie L
,
Xie L
. 2019.
Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing.
.
Int J Mol Sci. 20(14)
Wallace CH
,
Oliveros G
,
Xie L
,
Serrano P
,
Rockwell P
,
Figueiredo-Pereira M
. 2024.
Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology.
.
Sci Rep. 14(1):3730.
Liu Q
,
He D
,
Xie L
. 2019.
Prediction of off-target specificity and cell-specific fitness of CRISPR-Cas System using attention boosted deep learning and network-based gene feature.
.
PLoS Comput Biol. 15(10):e1007480.
R
Lim H
,
He D
,
Qiu Y
,
Krawczuk P
,
Sun X
,
Xie L
. 2019.
Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology.
.
PLoS Comput Biol. 15(6):e1006619.
Oliveros G
,
Wallace CH
,
Chaudry O
,
Liu Q
,
Qiu Y
,
Xie L
,
Rockwell P
,
Figueiredo-Pereira ME
,
Serrano PA
. 2023.
Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation.
.
Brain. 146(3):898-911.
S
Liao Z
,
Xie L
,
Mamitsuka H
,
Zhu S
. 2023.
Sc2Mol: a scaffold-based two-step molecule generator with variational autoencoder and transformer.
.
Bioinformatics. 39(1)
Liu Q
,
Lee B
,
Xie L
. 2022.
Small molecule modulation of microbiota: a systems pharmacology perspective.
.
BMC Bioinformatics. 23(Suppl 3):403.
T
Wallace CH
,
Oliveros G
,
Serrano PA
,
Rockwell P
,
Xie L
,
Figueiredo-Pereira M
. 2022.
Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer's model.
.
Life Sci Alliance. 5(12)
U
Zhang S
,
Liu Y
,
Xie L
. 2023.
A universal framework for accurate and efficient geometric deep learning of molecular systems.
.
Sci Rep. 13(1):19171.