Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 29 results
Author Title Type [ Year(Asc)]
Filters: Author is Sharma, Manu  [Clear All Filters]
2024
Guiberson NGuy Lewis, Black LS, Haller JE, Brukner A, Abramov D, Ahmad S, Xie YXin, Sharma M, Burré J.  2024.  Disease-linked mutations in Munc18-1 deplete synaptic Doc2.. Brain.
2023
Bravo CParra, Giani AMaria, Perez JMadero, Zhao Z, Samelson A, Wong MYing, Evangelisti A, Fan L, Pozner T, Mercedes M et al..  2023.  Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. bioRxiv.
Sharma M, Burré J.  2023.  α-Synuclein in synaptic function and dysfunction.. Trends Neurosci. 46(2):153-166.
2022
Burré J, Sharma M.  2022.  Cellular And Small Animal Models Of Neurodegenerative Diseases.. J Vis Exp. (186)
Xie YXue, Naseri NN, Fels J, Kharel P, Na Y, Lane D, Burré J, Sharma M.  2022.  Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.. Nat Commun. 13(1):4918.
Carnazza KE, Komer LE, Xie YXue, Pineda A, Briano JAntonio, Gao V, Na Y, Ramlall T, Buchman VL, Eliezer D et al..  2022.  Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.. Cell Rep. 39(2):110675.
2020
Naseri NN, Ergel B, Kharel P, Na Y, Huang Q, Huang R, Dolzhanskaya N, Burré J, Velinov MT, Sharma M.  2020.  Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.. Nat Struct Mol Biol. 27(2):192-201.
Naseri N, Sharma M, Velinov M.  2020.  Autosomal dominant neuronal ceroid lipofuscinosis: Clinical features and molecular basis.. Clin Genet.
Abramov D, Guiberson NGuy Lewis, Daab A, Na Y, Petsko GA, Sharma M, Burré J.  2020.  Targeted stabilization of Munc18-1 function via pharmacological chaperones.. EMBO Mol Med. :e12354.
2019
Naseri NN, Wang H, Guo J, Sharma M, Luo W.  2019.  The complexity of tau in Alzheimer's disease.. Neurosci Lett. 705:183-194.
2018
Burré J, Sharma M, Südhof TC.  2018.  Cell Biology and Pathophysiology of α-Synuclein.. Cold Spring Harb Perspect Med. 8(3)
2015
Burré J, Sharma M, Südhof TC.  2015.  Definition of a molecular pathway mediating α-synuclein neurotoxicity.. J Neurosci. 35(13):5221-32.
2014
Acuna C, Guo Q, Burré J, Sharma M, Sun J, Südhof TC.  2014.  Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity.. Neuron. 82(5):1088-100.
Lee SHun, Sharma M, Südhof TC, Shen J.  2014.  Synaptic function of nicastrin in hippocampal neurons.. Proc Natl Acad Sci U S A. 111(24):8973-8.
Burré J, Sharma M, Südhof TC.  2014.  α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.. Proc Natl Acad Sci U S A. 111(40):E4274-83.
2013
Diao J, Burré J, Vivona S, Cipriano DJ, Sharma M, Kyoung M, Südhof TC, Brunger AT.  2013.  Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.. Elife. 2:e00592.
Burré J, Vivona S, Diao J, Sharma M, Brunger AT, Südhof TC.  2013.  Properties of native brain α-synuclein.. Nature. 498(7453):E4-6;discussionE6-7.
2012
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC.  2012.  CSPα knockout causes neurodegeneration by impairing SNAP-25 function.. EMBO J. 31(4):829-41.
Sharma M, Burré J, Südhof TC.  2012.  Proteasome inhibition alleviates SNARE-dependent neurodegeneration.. Sci Transl Med. 4(147):147ra113.
Burré J, Sharma M, Südhof TC.  2012.  Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.. J Neurosci. 32(43):15227-42.
2011
Etherton MR, Tabuchi K, Sharma M, Ko J, Südhof TC.  2011.  An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.. EMBO J. 30(14):2908-19.
Sharma M, Burré J, Südhof TC.  2011.  CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.. Nat Cell Biol. 13(1):30-9.
2010
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Südhof TC.  2010.  Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.. Science. 329(5999):1663-7.
Mukherjee K, Sharma M, Jahn R, Wahl MC, Südhof TC.  2010.  Evolution of CASK into a Mg2+-sensitive kinase.. Sci Signal. 3(119):ra33.
2008
Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC.  2008.  CASK Functions as a Mg2+-independent neurexin kinase.. Cell. 133(2):328-39.