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Found 30 results
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Sharma, Manu
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2024
Guiberson NGuy Lewis
,
Black LS
,
Haller JE
,
Brukner A
,
Abramov D
,
Ahmad S
,
Xie YXin
,
Sharma M
,
Burré J
. 2024.
Disease-linked mutations in Munc18-1 deplete synaptic Doc2.
.
Brain.
Bravo CParra
,
Giani AMaria
,
Madero-Pérez J
,
Zhao Z
,
Wan Y
,
Samelson AJ
,
Wong MYing
,
Evangelisti A
,
Cordes E
,
Fan L
et al.
. 2024.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
.
Cell. 187(10):2446-2464.e22.
2023
Bravo CParra
,
Giani AMaria
,
Perez JMadero
,
Zhao Z
,
Samelson A
,
Wong MYing
,
Evangelisti A
,
Fan L
,
Pozner T
,
Mercedes M
et al.
. 2023.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
.
bioRxiv.
Sharma M
,
Burré J
. 2023.
α-Synuclein in synaptic function and dysfunction.
.
Trends Neurosci. 46(2):153-166.
2022
Burré J
,
Sharma M
. 2022.
Cellular And Small Animal Models Of Neurodegenerative Diseases.
.
J Vis Exp. (186)
Xie YXue
,
Naseri NN
,
Fels J
,
Kharel P
,
Na Y
,
Lane D
,
Burré J
,
Sharma M
. 2022.
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
.
Nat Commun. 13(1):4918.
Carnazza KE
,
Komer LE
,
Xie YXue
,
Pineda A
,
Briano JAntonio
,
Gao V
,
Na Y
,
Ramlall T
,
Buchman VL
,
Eliezer D
et al.
. 2022.
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.
.
Cell Rep. 39(2):110675.
2020
Naseri NN
,
Ergel B
,
Kharel P
,
Na Y
,
Huang Q
,
Huang R
,
Dolzhanskaya N
,
Burré J
,
Velinov MT
,
Sharma M
. 2020.
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
.
Nat Struct Mol Biol. 27(2):192-201.
Naseri N
,
Sharma M
,
Velinov M
. 2020.
Autosomal dominant neuronal ceroid lipofuscinosis: Clinical features and molecular basis.
.
Clin Genet.
Abramov D
,
Guiberson NGuy Lewis
,
Daab A
,
Na Y
,
Petsko GA
,
Sharma M
,
Burré J
. 2020.
Targeted stabilization of Munc18-1 function via pharmacological chaperones.
.
EMBO Mol Med. :e12354.
2019
Naseri NN
,
Wang H
,
Guo J
,
Sharma M
,
Luo W
. 2019.
The complexity of tau in Alzheimer's disease.
.
Neurosci Lett. 705:183-194.
2018
Burré J
,
Sharma M
,
Südhof TC
. 2018.
Cell Biology and Pathophysiology of α-Synuclein.
.
Cold Spring Harb Perspect Med. 8(3)
2015
Burré J
,
Sharma M
,
Südhof TC
. 2015.
Definition of a molecular pathway mediating α-synuclein neurotoxicity.
.
J Neurosci. 35(13):5221-32.
2014
Acuna C
,
Guo Q
,
Burré J
,
Sharma M
,
Sun J
,
Südhof TC
. 2014.
Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity.
.
Neuron. 82(5):1088-100.
Lee SHun
,
Sharma M
,
Südhof TC
,
Shen J
. 2014.
Synaptic function of nicastrin in hippocampal neurons.
.
Proc Natl Acad Sci U S A. 111(24):8973-8.
Burré J
,
Sharma M
,
Südhof TC
. 2014.
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
.
Proc Natl Acad Sci U S A. 111(40):E4274-83.
2013
Diao J
,
Burré J
,
Vivona S
,
Cipriano DJ
,
Sharma M
,
Kyoung M
,
Südhof TC
,
Brunger AT
. 2013.
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.
.
Elife. 2:e00592.
Burré J
,
Vivona S
,
Diao J
,
Sharma M
,
Brunger AT
,
Südhof TC
. 2013.
Properties of native brain α-synuclein.
.
Nature. 498(7453):E4-6;discussionE6-7.
2012
Sharma M
,
Burré J
,
Bronk P
,
Zhang Y
,
Xu W
,
Südhof TC
. 2012.
CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
.
EMBO J. 31(4):829-41.
Sharma M
,
Burré J
,
Südhof TC
. 2012.
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
.
Sci Transl Med. 4(147):147ra113.
Burré J
,
Sharma M
,
Südhof TC
. 2012.
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.
.
J Neurosci. 32(43):15227-42.
2011
Etherton MR
,
Tabuchi K
,
Sharma M
,
Ko J
,
Südhof TC
. 2011.
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
.
EMBO J. 30(14):2908-19.
Sharma M
,
Burré J
,
Südhof TC
. 2011.
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
.
Nat Cell Biol. 13(1):30-9.
2010
Burré J
,
Sharma M
,
Tsetsenis T
,
Buchman V
,
Etherton MR
,
Südhof TC
. 2010.
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
.
Science. 329(5999):1663-7.
Mukherjee K
,
Sharma M
,
Jahn R
,
Wahl MC
,
Südhof TC
. 2010.
Evolution of CASK into a Mg2+-sensitive kinase.
.
Sci Signal. 3(119):ra33.
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