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Found 40 results
Author
Title
Type
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]
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Paul, Steven M
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2020
Wong MYing
,
Lewis M
,
Doherty JJ
,
Shi Y
,
Cashikar AG
,
Amelianchik A
,
Tymchuk S
,
Sullivan PM
,
Qian M
,
Covey DF
et al.
. 2020.
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
.
J Neuroinflammation. 17(1):192.
2017
Shi Y
,
Yamada K
,
Liddelow SAntony
,
Smith ST
,
Zhao L
,
Luo W
,
Tsai RM
,
Spina S
,
Grinberg LT
,
Rojas JC
et al.
. 2017.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
.
Nature. 549(7673):523-527.
2016
Faraco G
,
Park L
,
Zhou P
,
Luo W
,
Paul SM
,
Anrather J
,
Iadecola C
. 2016.
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP.
.
J Cereb Blood Flow Metab. 36(1):241-52.
Zhao L
,
Gottesdiener AJ
,
Parmar M
,
Li M
,
Kaminsky SM
,
Chiuchiolo MJ
,
Sondhi D
,
Sullivan PM
,
Holtzman DM
,
Crystal RG
et al.
. 2016.
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
.
Neurobiol Aging. 44:159-72.
Yuan P
,
Condello C
,
C Keene D
,
Wang Y
,
Bird TD
,
Paul SM
,
Luo W
,
Colonna M
,
Baddeley D
,
Grutzendler J
. 2016.
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
.
Neuron. 92(1):252-264.
Yuan P
,
Condello C
,
C Keene D
,
Wang Y
,
Bird TD
,
Paul SM
,
Luo W
,
Colonna M
,
Baddeley D
,
Grutzendler J
. 2016.
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
.
Neuron. 90(4):724-39.
2015
Kember RL
,
Georgi B
,
Bailey-Wilson JE
,
Stambolian D
,
Paul SM
,
Bućan M
. 2015.
Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder.
.
BMC Genet. 16:27.
Luo W
,
Liu W
,
Hu X
,
Hanna M
,
Caravaca A
,
Paul SM
. 2015.
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
.
Sci Rep. 5:11161.
Kim KHye
,
Liu J
,
Galvin RJSells
,
Dage JL
,
Egeland JA
,
Smith RC
,
Merchant KM
,
Paul SM
. 2015.
Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree.
.
PLoS One. 10(11):e0142693.
2014
Linsenbardt AJ
,
Taylor A
,
Emnett CM
,
Doherty JJ
,
Krishnan K
,
Covey DF
,
Paul SM
,
Zorumski CF
,
Mennerick S
. 2014.
Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.
.
Neuropharmacology. 85:232-42.
Georgi B
,
Craig D
,
Kember RL
,
Liu W
,
Lindquist I
,
Nasser S
,
Brown C
,
Egeland JA
,
Paul SM
,
Bućan M
. 2014.
Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.
.
PLoS Genet. 10(3):e1004229.
Strauss KA
,
Markx S
,
Georgi B
,
Paul SM
,
Jinks RN
,
Hoshi T
,
McDonald A
,
First MB
,
Liu W
,
Benkert AR
et al.
. 2014.
A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.
.
Hum Mol Genet. 23(23):6395-406.
Rohan ML
,
Yamamoto RT
,
Ravichandran CT
,
Cayetano KR
,
Morales OG
,
Olson DP
,
Vitaliano G
,
Paul SM
,
Cohen BM
. 2014.
Rapid mood-elevating effects of low field magnetic stimulation in depression.
.
Biol Psychiatry. 76(3):186-93.
2013
Paul SM
,
Doherty JJ
,
Robichaud AJ
,
Belfort GM
,
Chow BY
,
Hammond RS
,
Crawford DC
,
Linsenbardt AJ
,
Shu H-J
,
Izumi Y
et al.
. 2013.
The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.
.
J Neurosci. 33(44):17290-300.
Zorumski CF
,
Paul SM
,
Izumi Y
,
Covey DF
,
Mennerick S
. 2013.
Neurosteroids, stress and depression: potential therapeutic opportunities.
.
Neurosci Biobehav Rev. 37(1):109-22.
2012
Hunter JM
,
Cirrito JR
,
Restivo JL
,
Kinley RD
,
Sullivan PM
,
Holtzman DM
,
Koger D
,
DeLong C
,
Lin S
,
Zhao L
et al.
. 2012.
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
.
Brain Res. 1467:120-32.
2011
Castellano JM
,
Kim J
,
Stewart FR
,
Jiang H
,
DeMattos RB
,
Patterson BW
,
Fagan AM
,
Morris JC
,
Mawuenyega KG
,
Cruchaga C
et al.
. 2011.
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
.
Sci Transl Med. 3(89):89ra57.
Paul SM
. 2011.
Therapeutic antibodies for brain disorders.
.
Sci Transl Med. 3(84):84ps20.
2010
Hurtado DE
,
Molina-Porcel L
,
Iba M
,
Aboagye AK
,
Paul SM
,
Trojanowski JQ
,
Lee VM-Y
. 2010.
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
.
Am J Pathol. 177(4):1977-88.
Paul SM
,
Mytelka DS
,
Dunwiddie CT
,
Persinger CC
,
Munos BH
,
Lindborg SR
,
Schacht AL
. 2010.
How to improve R&D productivity: the pharmaceutical industry's grand challenge.
.
Nat Rev Drug Discov. 9(3):203-14.
Siemers ER
,
Friedrich S
,
Dean RA
,
Gonzales CR
,
Farlow MR
,
Paul SM
,
DeMattos RB
. 2010.
Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.
.
Clin Neuropharmacol. 33(2):67-73.
2009
Bateman RJ
,
Siemers ER
,
Mawuenyega KG
,
Wen G
,
Browning KR
,
Sigurdson WC
,
Yarasheski KE
,
Friedrich SW
,
DeMattos RB
,
May PC
et al.
. 2009.
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.
.
Ann Neurol. 66(1):48-54.
Bales KR
,
Liu F
,
Wu S
,
Lin S
,
Koger D
,
DeLong C
,
Hansen JC
,
Sullivan PM
,
Paul SM
. 2009.
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
.
J Neurosci. 29(21):6771-9.
Zhao L
,
Lin S
,
Bales KR
,
Gelfanova V
,
Koger D
,
DeLong C
,
Hale J
,
Liu F
,
Hunter JM
,
Paul SM
. 2009.
Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.
.
J Neurosci. 29(11):3603-12.
Kim J
,
Castellano JM
,
Jiang H
,
Basak JM
,
Parsadanian M
,
Pham V
,
Mason SM
,
Paul SM
,
Holtzman DM
. 2009.
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
.
Neuron. 64(5):632-44.
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