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Found 40 results
Author
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Paul, Steven M
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2002
DeMattos RB
,
Bales KR
,
Cummins DJ
,
Paul SM
,
Holtzman DM
. 2002.
Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.
.
Science. 295(5563):2264-7.
DeMattos RB
,
O'dell MA
,
Parsadanian M
,
Taylor JW
,
Harmony JAK
,
Bales KR
,
Paul SM
,
Aronow BJ
,
Holtzman DM
. 2002.
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 99(16):10843-8.
Fagan AM
,
Watson M
,
Parsadanian M
,
Bales KR
,
Paul SM
,
Holtzman DM
. 2002.
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.
.
Neurobiol Dis. 9(3):305-18.
Dodart J-C
,
Bales KR
,
Gannon KS
,
Greene SJ
,
DeMattos RB
,
Mathis C
,
DeLong CA
,
Wu S
,
Wu X
,
Holtzman DM
et al.
. 2002.
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
.
Nat Neurosci. 5(5):452-7.
2003
Saura J
,
Petegnief V
,
Wu X
,
Liang Y
,
Paul SM
. 2003.
Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide.
.
J Neurochem. 85(6):1455-67.
Zhou Y
,
Su Y
,
Li B
,
Liu F
,
Ryder JW
,
Wu X
,
Gonzalez-DeWhitt PA
,
Gelfanova V
,
Hale JE
,
May PC
et al.
. 2003.
Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.
.
Science. 302(5648):1215-7.
2004
DeMattos RB
,
Cirrito JR
,
Parsadanian M
,
May PC
,
O'dell MA
,
Taylor JW
,
Harmony JAK
,
Aronow BJ
,
Bales KR
,
Paul SM
et al.
. 2004.
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.
.
Neuron. 41(2):193-202.
Koistinaho M
,
Lin S
,
Wu X
,
Esterman M
,
Koger D
,
Hanson J
,
Higgs R
,
Liu F
,
Malkani S
,
Bales KR
et al.
. 2004.
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.
.
Nat Med. 10(7):719-26.
Liang Y
,
Lin S
,
Beyer TP
,
Zhang Y
,
Wu X
,
Bales KR
,
DeMattos RB
,
May PC
,
Li SDan
,
Jiang X-C
et al.
. 2004.
A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.
.
J Neurochem. 88(3):623-34.
2005
Brendza RP
,
Bacskai BJ
,
Cirrito JR
,
Simmons KA
,
Skoch JM
,
Klunk WE
,
Mathis CA
,
Bales KR
,
Paul SM
,
Hyman BT
et al.
. 2005.
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
.
J Clin Invest. 115(2):428-33.
Wahrle SE
,
Jiang H
,
Parsadanian M
,
Hartman RE
,
Bales KR
,
Paul SM
,
Holtzman DM
. 2005.
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
.
J Biol Chem. 280(52):43236-42.
Dodart J-C
,
Marr RA
,
Koistinaho M
,
Gregersen BM
,
Malkani S
,
Verma IM
,
Paul SM
. 2005.
Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 102(4):1211-6.
Andersen OM
,
Reiche J
,
Schmidt V
,
Gotthardt M
,
Spoelgen R
,
Behlke J
,
von Arnim CAF
,
Breiderhoff T
,
Jansen P
,
Wu X
et al.
. 2005.
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
.
Proc Natl Acad Sci U S A. 102(38):13461-6.
Cirrito JR
,
Yamada KA
,
Finn MBeth
,
Sloviter RS
,
Bales KR
,
May PC
,
Schoepp DD
,
Paul SM
,
Mennerick S
,
Holtzman DM
. 2005.
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
.
Neuron. 48(6):913-22.
2006
Bales KR
,
Tzavara ET
,
Wu S
,
Wade MR
,
Bymaster FP
,
Paul SM
,
Nomikos GG
. 2006.
Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody.
.
J Clin Invest. 116(3):825-32.
2009
Bateman RJ
,
Siemers ER
,
Mawuenyega KG
,
Wen G
,
Browning KR
,
Sigurdson WC
,
Yarasheski KE
,
Friedrich SW
,
DeMattos RB
,
May PC
et al.
. 2009.
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.
.
Ann Neurol. 66(1):48-54.
Bales KR
,
Liu F
,
Wu S
,
Lin S
,
Koger D
,
DeLong C
,
Hansen JC
,
Sullivan PM
,
Paul SM
. 2009.
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
.
J Neurosci. 29(21):6771-9.
Zhao L
,
Lin S
,
Bales KR
,
Gelfanova V
,
Koger D
,
DeLong C
,
Hale J
,
Liu F
,
Hunter JM
,
Paul SM
. 2009.
Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.
.
J Neurosci. 29(11):3603-12.
Kim J
,
Castellano JM
,
Jiang H
,
Basak JM
,
Parsadanian M
,
Pham V
,
Mason SM
,
Paul SM
,
Holtzman DM
. 2009.
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
.
Neuron. 64(5):632-44.
2010
Hurtado DE
,
Molina-Porcel L
,
Iba M
,
Aboagye AK
,
Paul SM
,
Trojanowski JQ
,
Lee VM-Y
. 2010.
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
.
Am J Pathol. 177(4):1977-88.
Paul SM
,
Mytelka DS
,
Dunwiddie CT
,
Persinger CC
,
Munos BH
,
Lindborg SR
,
Schacht AL
. 2010.
How to improve R&D productivity: the pharmaceutical industry's grand challenge.
.
Nat Rev Drug Discov. 9(3):203-14.
Siemers ER
,
Friedrich S
,
Dean RA
,
Gonzales CR
,
Farlow MR
,
Paul SM
,
DeMattos RB
. 2010.
Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.
.
Clin Neuropharmacol. 33(2):67-73.
2011
Castellano JM
,
Kim J
,
Stewart FR
,
Jiang H
,
DeMattos RB
,
Patterson BW
,
Fagan AM
,
Morris JC
,
Mawuenyega KG
,
Cruchaga C
et al.
. 2011.
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
.
Sci Transl Med. 3(89):89ra57.
Paul SM
. 2011.
Therapeutic antibodies for brain disorders.
.
Sci Transl Med. 3(84):84ps20.
2012
Hunter JM
,
Cirrito JR
,
Restivo JL
,
Kinley RD
,
Sullivan PM
,
Holtzman DM
,
Koger D
,
DeLong C
,
Lin S
,
Zhao L
et al.
. 2012.
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
.
Brain Res. 1467:120-32.
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