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Found 71 results
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Gan, Li
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Ward ME
,
Chen R
,
Huang H-Y
,
Ludwig C
,
Telpoukhovskaia M
,
Taubes A
,
Boudin H
,
Minami SS
,
Reichert M
,
Albrecht P
et al.
. 2017.
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
.
Sci Transl Med. 9(385)
Boselli M
,
Lee B-H
,
Robert J
,
Prado MA
,
Min S-W
,
Cheng C
,
M Silva C
,
Seong C
,
Elsasser S
,
Hatle KM
et al.
. 2017.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
.
J Biol Chem. 292(47):19209-19225.
Esposito L
,
Gan L
,
Yu G-Q
,
Essrich C
,
Mucke L
. 2004.
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
.
J Neurochem. 91(6):1260-74.
L
Bhattacharjee A
,
Gan L
,
Kaczmarek LK
. 2002.
Localization of the Slack potassium channel in the rat central nervous system.
.
J Comp Neurol. 454(3):241-54.
M
Zhan L
,
Fan L
,
Kodama L
,
Sohn PDongmin
,
Wong MYing
,
Mousa GAlzaem
,
Zhou Y
,
Li Y
,
Gan L
. 2020.
A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.
.
Elife. 9
Sun B
,
Gan L
. 2011.
Manipulation of gene expression in the central nervous system with lentiviral vectors.
.
Methods Mol Biol. 670:155-68.
Song M
,
Yang X
,
Ren X
,
Maliskova L
,
Li B
,
Jones IR
,
Wang C
,
Jacob F
,
Wu K
,
Traglia M
et al.
. 2019.
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
.
Nat Genet. 51(8):1252-1262.
Kodama L
,
Guzman E
,
Etchegaray JI
,
Li Y
,
Sayed FA
,
Zhou L
,
Zhou Y
,
Zhan L
,
Le D
,
Udeochu JC
et al.
. 2019.
Microglial microRNAs mediate sex-specific responses to tau pathology.
.
Nat Neurosci.
Krabbe G
,
S Minami S
,
Etchegaray JI
,
Taneja P
,
Djukic B
,
Davalos D
,
Le D
,
Lo I
,
Zhan L
,
Reichert MC
et al.
. 2017.
Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
.
Proc Natl Acad Sci U S A. 114(19):5029-5034.
Snyder HM
,
Carare RO
,
DeKosky ST
,
de Leon MJ
,
Dykxhoorn D
,
Gan L
,
Gardner R
,
Hinds SR
,
Jaffee M
,
Lamb BT
et al.
. 2018.
Military-related risk factors for dementia.
.
Alzheimers Dement. 14(12):1651-1662.
Kuo S-H
,
Tasset I
,
Cheng MM
,
Diaz A
,
Pan M-K
,
Lieberman OJ
,
Hutten SJ
,
Alcalay RN
,
Kim S
,
Ximénez-Embún P
et al.
. 2022.
Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
.
Sci Adv. 8(6):eabm6393.
N
Zhu PK
,
W Zheng S
,
Zhang P
,
Jing M
,
Borden PM
,
Ali F
,
Guo K
,
Feng J
,
Marvin JS
,
Wang Y
et al.
. 2020.
Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.
.
Nano Lett. 20(6):4073-4083.
Martinez-Losa M
,
Tracy TE
,
Ma K
,
Verret L
,
Clemente-Perez A
,
Khan AS
,
Cobos I
,
Ho K
,
Gan L
,
Mucke L
et al.
. 2018.
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.
.
Neuron. 98(1):75-89.e5.
Ford BD
,
Liu Y
,
Mann MAnne
,
Krauss R
,
Phillips K
,
Gan L
,
Fischbach GD
. 2003.
Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes.
.
Biochem Biophys Res Commun. 308(1):23-8.
Amin S
,
Carling G
,
Gan L
. 2021.
New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.
.
Curr Opin Neurobiol. 72:131-139.
Gresch O
,
Engel FB
,
Nesic D
,
Tran TThai
,
England HM
,
Hickman ES
,
Körner I
,
Gan L
,
Chen S
,
Castro-Obregon S
et al.
. 2004.
New non-viral method for gene transfer into primary cells.
.
Methods. 33(2):151-63.
P
Sohn PDongmin
,
Huang CTzu-Ling
,
Yan R
,
Fan L
,
Tracy TE
,
Camargo CM
,
Montgomery KM
,
Arhar T
,
Mok S-A
,
Freilich R
et al.
. 2019.
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
.
Neuron.
Gan L
,
Mucke L
. 2008.
Paths of convergence: sirtuins in aging and neurodegeneration.
.
Neuron. 58(1):10-4.
Sanchez-Mejia RO
,
Newman JW
,
Toh S
,
Yu G-Q
,
Zhou Y
,
Halabisky B
,
Cissé M
,
Scearce-Levie K
,
Cheng IH
,
Gan L
et al.
. 2008.
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
.
Nat Neurosci. 11(11):1311-8.
Kauppinen TM
,
Gan L
,
Swanson RA
. 2013.
Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.
.
Biochim Biophys Acta. 1833(8):1985-91.
Kauppinen TM
,
Suh SWon
,
Higashi Y
,
Berman AE
,
Escartin C
,
Won SJoon
,
Wang C
,
Cho S-H
,
Gan L
,
Swanson RA
. 2011.
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.
.
J Neuroinflammation. 8:152.
Lin L-C
,
Nana AL
,
Hepker M
,
Hwang J-HLee
,
Gaus SE
,
Spina S
,
Cosme CG
,
Gan L
,
Grinberg LT
,
Geschwind DH
et al.
. 2019.
Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.
.
Acta Neuropathol Commun. 7(1):159.
Martens LHerl
,
Zhang J
,
Barmada SJ
,
Zhou P
,
Kamiya S
,
Sun B
,
Min S-W
,
Gan L
,
Finkbeiner S
,
Huang EJ
et al.
. 2012.
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
.
J Clin Invest. 122(11):3955-9.
S Minami S
,
Min S-W
,
Krabbe G
,
Wang C
,
Zhou Y
,
Asgarov R
,
Li Y
,
Martens LH
,
Elia LP
,
Ward ME
et al.
. 2014.
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
.
Nat Med. 20(10):1157-64.
Chen X
,
Li Y
,
Wang C
,
Tang Y
,
Mok S-A
,
Tsai RM
,
Rojas JC
,
Karydas A
,
Miller BL
,
Boxer AL
et al.
. 2020.
Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
.
Mol Neurodegener. 15(1):2.
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