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Publications

Found 71 results
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Zhan L, Fan L, Kodama L, Sohn PDongmin, Wong MYing, Mousa GAlzaem, Zhou Y, Li Y, Gan L.  2020.  A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.. Elife. 9
Sun B, Gan L.  2011.  Manipulation of gene expression in the central nervous system with lentiviral vectors.. Methods Mol Biol. 670:155-68.
Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M et al..  2019.  Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.. Nat Genet. 51(8):1252-1262.
Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC et al..  2019.  Microglial microRNAs mediate sex-specific responses to tau pathology.. Nat Neurosci.
Krabbe G, S Minami S, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC et al..  2017.  Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.. Proc Natl Acad Sci U S A. 114(19):5029-5034.
Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT et al..  2018.  Military-related risk factors for dementia.. Alzheimers Dement. 14(12):1651-1662.
Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al..  2022.  Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.
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Sohn PDongmin, Huang CTzu-Ling, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok S-A, Freilich R et al..  2019.  Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.. Neuron.
Gan L, Mucke L.  2008.  Paths of convergence: sirtuins in aging and neurodegeneration.. Neuron. 58(1):10-4.
Sanchez-Mejia RO, Newman JW, Toh S, Yu G-Q, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L et al..  2008.  Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.. Nat Neurosci. 11(11):1311-8.
Kauppinen TM, Gan L, Swanson RA.  2013.  Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.. Biochim Biophys Acta. 1833(8):1985-91.
Kauppinen TM, Suh SWon, Higashi Y, Berman AE, Escartin C, Won SJoon, Wang C, Cho S-H, Gan L, Swanson RA.  2011.  Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.. J Neuroinflammation. 8:152.
Lin L-C, Nana AL, Hepker M, Hwang J-HLee, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH et al..  2019.  Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.. Acta Neuropathol Commun. 7(1):159.
Martens LHerl, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min S-W, Gan L, Finkbeiner S, Huang EJ et al..  2012.  Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.. J Clin Invest. 122(11):3955-9.
S Minami S, Min S-W, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME et al..  2014.  Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.. Nat Med. 20(10):1157-64.
Chen X, Li Y, Wang C, Tang Y, Mok S-A, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL et al..  2020.  Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.. Mol Neurodegener. 15(1):2.