Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 74 results

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Kauppinen TM, Suh SWon, Higashi Y, Berman AE, Escartin C, Won SJoon, Wang C, Cho S-H, Gan L, Swanson RA. 2011. Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.. J Neuroinflammation. 8:152.

Kauppinen TM, Gan L, Swanson RA. 2013. Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.. Biochim Biophys Acta. 1833(8):1985-91.

Sanchez-Mejia RO, Newman JW, Toh S, Yu G-Q, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L et al.. 2008. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.. Nat Neurosci. 11(11):1311-8.

Gan L, Mucke L. 2008. Paths of convergence: sirtuins in aging and neurodegeneration.. Neuron. 58(1):10-4.

Sohn PDongmin, Huang CTzu-Ling, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok S-A, Freilich R et al.. 2019. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.. Neuron.

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Gresch O, Engel FB, Nesic D, Tran TThai, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S et al.. 2004. New non-viral method for gene transfer into primary cells.. Methods. 33(2):151-63.

Amin S, Carling G, Gan L. 2021. New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.. Curr Opin Neurobiol. 72:131-139.

Ford BD, Liu Y, Mann MAnne, Krauss R, Phillips K, Gan L, Fischbach GD. 2003. Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes.. Biochem Biophys Res Commun. 308(1):23-8.

Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L et al.. 2018. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.. Neuron. 98(1):75-89.e5.

Zhu PK, W Zheng S, Zhang P, Jing M, Borden PM, Ali F, Guo K, Feng J, Marvin JS, Wang Y et al.. 2020. Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.. Nano Lett. 20(6):4073-4083.

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Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al.. 2022. Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.

Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT et al.. 2018. Military-related risk factors for dementia.. Alzheimers Dement. 14(12):1651-1662.

Krabbe G, S Minami S, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC et al.. 2017. Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.. Proc Natl Acad Sci U S A. 114(19):5029-5034.

Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al.. 2022. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.

Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC et al.. 2019. Microglial microRNAs mediate sex-specific responses to tau pathology.. Nat Neurosci.

Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M et al.. 2019. Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.. Nat Genet. 51(8):1252-1262.

Sun B, Gan L. 2011. Manipulation of gene expression in the central nervous system with lentiviral vectors.. Methods Mol Biol. 670:155-68.

Zhan L, Fan L, Kodama L, Sohn PDongmin, Wong MYing, Mousa GAlzaem, Zhou Y, Li Y, Gan L. 2020. A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.. Elife. 9

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Bhattacharjee A, Gan L, Kaczmarek LK. 2002. Localization of the Slack potassium channel in the rat central nervous system.. J Comp Neurol. 454(3):241-54.

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Esposito L, Gan L, Yu G-Q, Essrich C, Mucke L. 2004. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.. J Neurochem. 91(6):1260-74.

Boselli M, Lee B-H, Robert J, Prado MA, Min S-W, Cheng C, M Silva C, Seong C, Elsasser S, Hatle KM et al.. 2017. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.. J Biol Chem. 292(47):19209-19225.

Ward ME, Chen R, Huang H-Y, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P et al.. 2017. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.. Sci Transl Med. 9(385)

Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. 2009. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.. Cell Stem Cell. 5(6):624-33.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S et al.. 2004. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.. J Biol Chem. 279(7):5565-72.

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Dong Q, Gentry NW, McMahon T, Yamazaki M, Benitez-Rivera L, Wang T, Gan L, Ptáček L, Fu Y-H. 2022. Familial natural short sleep mutations reduce Alzheimer pathology in mice.. iScience. 25(4):103964.