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G
Bateman RJ
,
Siemers ER
,
Mawuenyega KG
,
Wen G
,
Browning KR
,
Sigurdson WC
,
Yarasheski KE
,
Friedrich SW
,
DeMattos RB
,
May PC
et al.
. 2009.
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.
.
Ann Neurol. 66(1):48-54.
Dodart J-C
,
Marr RA
,
Koistinaho M
,
Gregersen BM
,
Malkani S
,
Verma IM
,
Paul SM
. 2005.
Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.
.
Proc Natl Acad Sci U S A. 102(4):1211-6.
Sparwasser T
,
Gong S
,
Li JYH
,
Eberl G
. 2004.
General method for the modification of different BAC types and the rapid generation of BAC transgenic mice.
.
Genesis. 38(1):39-50.
Ginns EI
,
St Jean P
,
Philibert RA
,
Galdzicka M
,
Damschroder-Williams P
,
Thiel B
,
Long RT
,
Ingraham LJ
,
Dalwaldi H
,
Murray MA
et al.
. 1998.
A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish.
.
Proc Natl Acad Sci U S A. 95(26):15531-6.
Georgi B
,
Craig D
,
Kember RL
,
Liu W
,
Lindquist I
,
Nasser S
,
Brown C
,
Egeland JA
,
Paul SM
,
Bućan M
. 2014.
Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.
.
PLoS Genet. 10(3):e1004229.
Heintz N
,
Gong S
. 2020.
Growth of and Preparation of DNA.
.
Cold Spring Harb Protoc. 2020(10)
Xu P
,
Chang JC
,
Zhou X
,
Wang W
,
Bamkole M
,
Wong E
,
Bettayeb K
,
Jiang L-L
,
Huang T
,
Luo W
et al.
. 2021.
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.
.
J Exp Med. 218(8)
H
Gong S
,
Yang XWilliam
,
Li C
,
Heintz N
. 2002.
Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication.
.
Genome Res. 12(12):1992-8.
Paul SM
,
Mytelka DS
,
Dunwiddie CT
,
Persinger CC
,
Munos BH
,
Lindborg SR
,
Schacht AL
. 2010.
How to improve R&D productivity: the pharmaceutical industry's grand challenge.
.
Nat Rev Drug Discov. 9(3):203-14.
Fagan AM
,
Watson M
,
Parsadanian M
,
Bales KR
,
Paul SM
,
Holtzman DM
. 2002.
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.
.
Neurobiol Dis. 9(3):305-18.
Bales KR
,
Liu F
,
Wu S
,
Lin S
,
Koger D
,
DeLong C
,
Hansen JC
,
Sullivan PM
,
Paul SM
. 2009.
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
.
J Neurosci. 29(21):6771-9.
Castellano JM
,
Kim J
,
Stewart FR
,
Jiang H
,
DeMattos RB
,
Patterson BW
,
Fagan AM
,
Morris JC
,
Mawuenyega KG
,
Cruchaga C
et al.
. 2011.
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
.
Sci Transl Med. 3(89):89ra57.
Faraco G
,
Park L
,
Zhou P
,
Luo W
,
Paul SM
,
Anrather J
,
Iadecola C
. 2016.
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP.
.
J Cereb Blood Flow Metab. 36(1):241-52.
I
Burré J
,
Zimmermann H
,
Volknandt W
. 2007.
Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.
.
J Neurochem. 103(1):276-87.
Gan L
,
Ye S
,
Chu A
,
Anton K
,
Yi S
,
Vincent VA
,
von Schack D
,
Chin D
,
Murray J
,
Lohr S
et al.
. 2004.
Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.
.
J Biol Chem. 279(7):5565-72.
Sun B
,
Halabisky B
,
Zhou Y
,
Palop JJ
,
Yu G
,
Mucke L
,
Gan L
. 2009.
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
.
Cell Stem Cell. 5(6):624-33.
Dodart J-C
,
Bales KR
,
Gannon KS
,
Greene SJ
,
DeMattos RB
,
Mathis C
,
DeLong CA
,
Wu S
,
Wu X
,
Holtzman DM
et al.
. 2002.
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
.
Nat Neurosci. 5(5):452-7.
Burré J
,
Zimmermann H
,
Volknandt W
. 2007.
Immunoisolation and subfractionation of synaptic vesicle proteins.
.
Anal Biochem. 362(2):172-81.
Morciano M
,
Burré J
,
Corvey C
,
Karas M
,
Zimmermann H
,
Volknandt W
. 2005.
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
.
J Neurochem. 95(6):1732-45.
Li X-J
,
Orr AL
,
Li S
. 2010.
Impaired mitochondrial trafficking in Huntington's disease.
.
Biochim Biophys Acta. 1802(1):62-5.
Hansen KB
,
Mullasseril P
,
Dawit S
,
Kurtkaya NL
,
Yuan H
,
Vance KM
,
Orr AG
,
Kvist T
,
Ogden KK
,
Le P
et al.
. 2010.
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
.
J Pharmacol Exp Ther. 333(3):650-62.
Sang T-K
,
Li C
,
Liu W
,
Rodriguez A
,
Abrams JM
,
S Zipursky L
,
Jackson GR
. 2005.
Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.
.
Hum Mol Genet. 14(3):357-72.
Ward ME
,
Chen R
,
Huang H-Y
,
Ludwig C
,
Telpoukhovskaia M
,
Taubes A
,
Boudin H
,
Minami SS
,
Reichert M
,
Albrecht P
et al.
. 2017.
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
.
Sci Transl Med. 9(385)
Boselli M
,
Lee B-H
,
Robert J
,
Prado MA
,
Min S-W
,
Cheng C
,
M Silva C
,
Seong C
,
Elsasser S
,
Hatle KM
et al.
. 2017.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
.
J Biol Chem. 292(47):19209-19225.
Orr AL
,
Ashok D
,
Sarantos MR
,
Shi T
,
Hughes RE
,
Brand MD
. 2013.
Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.
.
Free Radic Biol Med. 65:1047-1059.
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