News and Events | Page 11 | Helen & Robert Appel Alzheimer’s Disease Research Institute

Dr. Jacqueline Burré: Winner of the BMRI Mentor of the Year Award in Neuroscience!

This award consists of $10,000 for research-related expenses at the discretion of the winner. Nominations were received for 7 faculty members and were evaluated on areas of mentor-ship building, scientific training and communication. The review committee was impressed with all the nominations but felt that Dr. Burré deserved special recognition for her outstanding contribution to supporting research training in our community. Congratulations...

Distinguished Chemist, Dr. Subhash Sinha, Joining Appel Institute to Boost Translational Research

Dr. Sinha is a synthetic medicinal chemist at the Helen and Robert Appel Alzheimer’s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine. Dr. Sinha received his doctorate in Chemistry-Medicinal Chemistry in 1987 from Banaras Hindu University, India. He completed postdoctoral training at Tohoku University, Japan, Technion-Israel Institute of Technology, Israel, and at The Scripps Research Institute, California. He joined the Scripps faculty as an Assistant...

An Unusual Mechanism of Pathogenic Aggregation of Cysteine String Protein-α (CSPα)

A new discovery published in Nature Structural & Molecular Biology (Naseri NN et al. Nat Struct & Mol Biol 27(2):192-201; 2020) clarifies the mechanism behind a neurodegenerative lysosomal storage disease: Mutations in cysteine string protein-α (CSPα) cause its aggregation and adult-onset neuronal ceroid lipofuscinosis (ANCL or Kufs disease). Abnormal binding of Fe-S clusters to CSPα mutants is shown to drive this disease-causing aggregation, which can be reversed in...

Microglial microRNAs mediate sex-specific responses to tau pathology

A new discovery published in Nature Neuroscience showed that male and female microglia expressed different sets of microRNAs at baseline and in response to tau pathology. Led by graduate student Lay Kodama in Gan lab, the study found that removal of microRNAs exacerbated tau aggregates in male but not in female tauopathy mice.

On the single cell level, only male, but not female, mice had increased number of disease associated microglia (DAMs) and decreased homeostatic microglia after...

Seventh Annual Appel Alzheimer's Disease Research Institute Symposium to be held on October 04, 2019

The Seventh Annual Appel Alzheimer's Disease Research Institute Symposium is scheduled on Friday, October 4th, 2019 from 8:30AM - 12:00 PM at the Belfer Research Building, Starr-Greenberg Conference Center/ Ruben Family Conference Center on the 3rd Floor.

This is an outstanding annual event hosted by Dean Choi, Appel Alzheimer's Institute and the Feil Family BMRI. Dr.Li Gan, Director of the Appel Institute will open the symposium, followed by four cutting edge scientific presentations...